ENSG00000165861

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000394207 ENSG00000165861 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFYVE1 protein_coding protein_coding 6.808916 10.07584 3.63032 1.058241 0.3134795 -1.470195 0.60973618 1.9514750 0.0000000 0.6776812 0.0000000 -7.6157951 0.06583333 0.18486667 0.0000000 -0.18486667 5.499813e-07 5.499813e-07 FALSE TRUE
ENST00000553891 ENSG00000165861 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFYVE1 protein_coding protein_coding 6.808916 10.07584 3.63032 1.058241 0.3134795 -1.470195 0.03843057 0.0000000 0.3074446 0.0000000 0.3074446 4.9884327 0.01015000 0.00000000 0.0812000 0.08120000 7.585786e-01 5.499813e-07 FALSE TRUE
ENST00000556143 ENSG00000165861 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFYVE1 protein_coding protein_coding 6.808916 10.07584 3.63032 1.058241 0.3134795 -1.470195 4.99455398 7.2420191 2.8764203 0.4081424 0.1352798 -1.3291013 0.73998750 0.72640000 0.7985667 0.07216667 7.777169e-01 5.499813e-07 FALSE TRUE
MSTRG.9849.4 ENSG00000165861 HEK293_OSMI2_6hA HEK293_TMG_6hB ZFYVE1 protein_coding   6.808916 10.07584 3.63032 1.058241 0.3134795 -1.470195 0.59998671 0.3529373 0.3041926 0.1765787 0.1883917 -0.2080712 0.10819167 0.03346667 0.0821000 0.04863333 9.099717e-01 5.499813e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000165861 E001 0.5115862 0.0209623348 0.69271519   14 72969451 72969451 1 - 0.200 0.132 -0.715
ENSG00000165861 E002 45.3946582 0.0010290415 0.17466234 0.39671096 14 72969452 72969756 305 - 1.535 1.610 0.253
ENSG00000165861 E003 142.1666406 0.0004004393 0.09670315 0.27596529 14 72969757 72970710 954 - 2.043 2.089 0.155
ENSG00000165861 E004 54.1914647 0.0162096097 0.63594055 0.79424987 14 72970711 72970877 167 - 1.641 1.677 0.123
ENSG00000165861 E005 27.4139378 0.0181724077 0.62508777 0.78737877 14 72970878 72970881 4 - 1.419 1.369 -0.174
ENSG00000165861 E006 28.6097424 0.0105547297 0.42731014 0.64895739 14 72970882 72970892 11 - 1.455 1.382 -0.253
ENSG00000165861 E007 30.4779522 0.0012243691 0.67608351 0.82022727 14 72970893 72970929 37 - 1.454 1.414 -0.139
ENSG00000165861 E008 61.0519244 0.0024419617 0.30654028 0.54718553 14 72970930 72971114 185 - 1.679 1.729 0.168
ENSG00000165861 E009 0.2735028 0.0260479858 0.39484275   14 72974078 72974079 2 - 0.200 0.071 -1.716
ENSG00000165861 E010 64.3884270 0.0023488768 0.55398776 0.73911604 14 72974080 72974193 114 - 1.724 1.748 0.080
ENSG00000165861 E011 46.3586441 0.0073596164 0.80560121 0.89944725 14 72974779 72974827 49 - 1.597 1.608 0.036
ENSG00000165861 E012 73.2053122 0.0006074961 0.59957722 0.76992080 14 72974828 72974959 132 - 1.783 1.797 0.049
ENSG00000165861 E013 1.3083691 0.1514104129 0.97290048   14 72974960 72975207 248 - 0.334 0.319 -0.096
ENSG00000165861 E014 79.3546416 0.0007702581 0.39318379 0.62293070 14 72975551 72975721 171 - 1.803 1.833 0.100
ENSG00000165861 E015 0.5061644 0.3005497533 0.70512749   14 72975722 72975941 220 - 0.200 0.134 -0.697
ENSG00000165861 E016 43.1790934 0.0008465139 0.70200323 0.83684800 14 72977927 72977963 37 - 1.557 1.570 0.045
ENSG00000165861 E017 39.8384245 0.0111078409 0.38355670 0.61520570 14 72977964 72978002 39 - 1.480 1.544 0.218
ENSG00000165861 E018 37.0299361 0.0067859581 0.45933441 0.67271144 14 72978003 72978044 42 - 1.463 1.511 0.165
ENSG00000165861 E019 45.0474149 0.0168059169 0.92506165 0.96482548 14 72978137 72978234 98 - 1.590 1.581 -0.029
ENSG00000165861 E020 43.6304936 0.0172058528 0.91726588 0.96083124 14 72978861 72978969 109 - 1.563 1.573 0.034
ENSG00000165861 E021 1.3325720 0.0129693713 0.93885741   14 72978970 72979225 256 - 0.336 0.316 -0.128
ENSG00000165861 E022 34.0973941 0.0014071418 0.01519601 0.07882682 14 72981789 72981895 107 - 1.591 1.420 -0.585
ENSG00000165861 E023 0.0000000       14 72986892 72986896 5 -      
ENSG00000165861 E024 0.1614157 0.0320661766 0.14128703   14 72986897 72986985 89 - 0.200 0.000 -10.783
ENSG00000165861 E025 52.7452734 0.0011470455 0.09976508 0.28134183 14 72993143 72993357 215 - 1.729 1.629 -0.341
ENSG00000165861 E026 102.2096403 0.0005263792 0.28974382 0.53030235 14 72997811 72998315 505 - 1.978 1.925 -0.177
ENSG00000165861 E027 141.5412048 1.1336695810 0.69243482 0.83062929 14 73024026 73024861 836 - 2.107 2.070 -0.124
ENSG00000165861 E028 25.7250430 0.3398430873 0.96728352 0.98561179 14 73024862 73024942 81 - 1.483 1.309 -0.603
ENSG00000165861 E029 27.6063986 0.2084811342 0.49283338 0.69588590 14 73026926 73027146 221 - 1.341 1.397 0.194