ENSG00000165813

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369286 ENSG00000165813 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC186 protein_coding protein_coding 3.511012 0.5784135 7.744778 0.07504261 0.2917008 3.720183 0.1143963 0.02947464 0.2651514 0.01680001 0.02396890 2.801227 0.05553333 0.05883333 0.03453333 -0.02430000 9.320342e-01 1.238676e-05 FALSE TRUE
ENST00000369287 ENSG00000165813 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC186 protein_coding protein_coding 3.511012 0.5784135 7.744778 0.07504261 0.2917008 3.720183 1.3931935 0.41434851 2.6666504 0.06469949 0.16994015 2.657107 0.48383333 0.72360000 0.34446667 -0.37913333 2.326073e-02 1.238676e-05 FALSE TRUE
ENST00000490661 ENSG00000165813 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC186 protein_coding retained_intron 3.511012 0.5784135 7.744778 0.07504261 0.2917008 3.720183 0.2660044 0.08377456 0.7102350 0.08377456 0.24221190 2.941199 0.05799583 0.11503333 0.09163333 -0.02340000 9.776489e-01 1.238676e-05 FALSE FALSE
ENST00000497592 ENSG00000165813 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC186 protein_coding processed_transcript 3.511012 0.5784135 7.744778 0.07504261 0.2917008 3.720183 0.2057119 0.00000000 0.4536877 0.00000000 0.06232041 5.535082 0.06406667 0.00000000 0.05886667 0.05886667 2.477160e-01 1.238676e-05   FALSE
ENST00000648613 ENSG00000165813 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC186 protein_coding protein_coding 3.511012 0.5784135 7.744778 0.07504261 0.2917008 3.720183 0.5200077 0.05081577 1.1868596 0.05081577 0.06476958 4.298665 0.17412917 0.10253333 0.15416667 0.05163333 7.531723e-01 1.238676e-05 FALSE TRUE
MSTRG.4670.4 ENSG00000165813 HEK293_OSMI2_6hA HEK293_TMG_6hB CCDC186 protein_coding   3.511012 0.5784135 7.744778 0.07504261 0.2917008 3.720183 0.9489672 0.00000000 2.4621940 0.00000000 0.25391095 7.949648 0.15037083 0.00000000 0.31640000 0.31640000 1.238676e-05 1.238676e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000165813 E001 0.2027342 0.040608356 3.294699e-02   10 114120862 114120900 39 - 0.000 0.298 12.191
ENSG00000165813 E002 198.1063119 0.003408273 3.307784e-06 8.072105e-05 10 114120901 114124928 4028 - 2.056 2.236 0.603
ENSG00000165813 E003 8.2166090 0.099061758 1.996970e-01 4.292804e-01 10 114124929 114124951 23 - 0.795 0.476 -1.397
ENSG00000165813 E004 30.9364360 0.014050869 1.393003e-01 3.464412e-01 10 114124952 114125226 275 - 1.309 1.138 -0.604
ENSG00000165813 E005 28.4655479 0.010264970 8.097168e-02 2.467488e-01 10 114125886 114126105 220 - 1.277 1.071 -0.735
ENSG00000165813 E006 30.2867385 0.001576184 4.282096e-01 6.495975e-01 10 114127461 114127671 211 - 1.291 1.223 -0.242
ENSG00000165813 E007 25.9518225 0.001447111 5.194991e-01 7.147027e-01 10 114129891 114129971 81 - 1.226 1.168 -0.203
ENSG00000165813 E008 3.0645794 0.007495740 4.540605e-01 6.687800e-01 10 114130199 114130669 471 - 0.464 0.297 -0.961
ENSG00000165813 E009 2.8089323 0.007783039 3.944321e-01 6.239336e-01 10 114131026 114131146 121 - 0.413 0.596 0.886
ENSG00000165813 E010 33.1944384 0.001118837 8.260325e-01 9.115070e-01 10 114131147 114131336 190 - 1.321 1.314 -0.024
ENSG00000165813 E011 31.5913099 0.001296733 6.245039e-01 7.870154e-01 10 114131929 114132184 256 - 1.305 1.271 -0.121
ENSG00000165813 E012 21.5289186 0.001821698 6.247172e-01 7.871723e-01 10 114134913 114135055 143 - 1.151 1.106 -0.160
ENSG00000165813 E013 25.3853100 0.002170831 5.909327e-01 7.643284e-01 10 114135891 114135977 87 - 1.214 1.168 -0.164
ENSG00000165813 E014 26.4816061 0.001372081 3.061600e-01 5.468229e-01 10 114136148 114136246 99 - 1.239 1.138 -0.358
ENSG00000165813 E015 26.1399937 0.001518932 3.310998e-01 5.699725e-01 10 114137186 114137290 105 - 1.234 1.138 -0.339
ENSG00000165813 E016 26.8463737 0.001470066 5.827642e-01 7.588701e-01 10 114144497 114144616 120 - 1.241 1.196 -0.160
ENSG00000165813 E017 33.3380667 0.001095504 8.416157e-01 9.203912e-01 10 114145549 114145761 213 - 1.321 1.354 0.114
ENSG00000165813 E018 25.2608362 0.001971699 8.076418e-01 9.007786e-01 10 114151092 114151220 129 - 1.209 1.196 -0.045
ENSG00000165813 E019 19.5797196 0.001772016 8.636947e-02 2.571580e-01 10 114157554 114157680 127 - 1.121 0.896 -0.829
ENSG00000165813 E020 3.4043388 0.007145680 5.433650e-01 7.314459e-01 10 114161608 114162636 1029 - 0.464 0.596 0.625
ENSG00000165813 E021 51.7387083 0.007960703 6.790628e-01 8.221322e-01 10 114162637 114163329 693 - 1.505 1.484 -0.073
ENSG00000165813 E022 4.3977869 0.006561269 6.327950e-01 7.921654e-01 10 114173141 114173265 125 - 0.563 0.472 -0.436
ENSG00000165813 E023 15.1117181 0.081482121 3.616670e-01 5.970260e-01 10 114174015 114174104 90 - 1.015 0.835 -0.682
ENSG00000165813 E024 9.8818987 0.090650144 7.477191e-01 8.653210e-01 10 114174105 114174232 128 - 0.844 0.768 -0.298