ENSG00000165792

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000339374 ENSG00000165792 HEK293_OSMI2_6hA HEK293_TMG_6hB METTL17 protein_coding protein_coding 103.6111 95.54836 101.4488 7.292771 1.748909 0.08643981 36.845376 33.185569 27.605190 5.1124085 1.1070005 -0.26552863 0.35618750 0.35760000 0.27196667 -0.085633333 0.78497595 0.01256812 FALSE  
ENST00000382985 ENSG00000165792 HEK293_OSMI2_6hA HEK293_TMG_6hB METTL17 protein_coding protein_coding 103.6111 95.54836 101.4488 7.292771 1.748909 0.08643981 29.695404 27.287397 28.109636 2.0410765 1.6304055 0.04281457 0.28303750 0.28626667 0.27776667 -0.008500000 0.97306677 0.01256812 FALSE  
ENST00000553389 ENSG00000165792 HEK293_OSMI2_6hA HEK293_TMG_6hB METTL17 protein_coding retained_intron 103.6111 95.54836 101.4488 7.292771 1.748909 0.08643981 5.483999 5.468287 6.252805 2.2189184 0.4419618 0.19308408 0.05223750 0.05453333 0.06180000 0.007266667 0.89873783 0.01256812 FALSE  
ENST00000555533 ENSG00000165792 HEK293_OSMI2_6hA HEK293_TMG_6hB METTL17 protein_coding nonsense_mediated_decay 103.6111 95.54836 101.4488 7.292771 1.748909 0.08643981 6.537429 10.570726 4.250535 0.2588536 1.0447023 -1.31233216 0.06166667 0.11153333 0.04156667 -0.069966667 0.01256812 0.01256812 FALSE  
ENST00000555640 ENSG00000165792 HEK293_OSMI2_6hA HEK293_TMG_6hB METTL17 protein_coding nonsense_mediated_decay 103.6111 95.54836 101.4488 7.292771 1.748909 0.08643981 5.224076 3.175412 7.776481 1.4603726 0.2907670 1.28949173 0.05180000 0.03146667 0.07670000 0.045233333 0.18867376 0.01256812 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000165792 E001 7.5233463 0.0043040476 0.6726395622 0.817986092 14 20989973 20989979 7 + 0.879 0.954 0.286
ENSG00000165792 E002 11.4887491 0.0051683209 0.9257590509 0.965049072 14 20989980 20989986 7 + 1.077 1.095 0.064
ENSG00000165792 E003 44.2021903 0.0145376969 0.0004857921 0.005546129 14 20989987 20989993 7 + 1.770 1.526 -0.829
ENSG00000165792 E004 66.5306979 0.0055790085 0.0361409221 0.144597500 14 20989994 20989995 2 + 1.870 1.783 -0.293
ENSG00000165792 E005 79.7918080 0.0012859421 0.2785886689 0.518684437 14 20989996 20989998 3 + 1.910 1.892 -0.059
ENSG00000165792 E006 90.0285816 0.0016242424 0.4561509079 0.670349569 14 20989999 20990001 3 + 1.952 1.950 -0.006
ENSG00000165792 E007 94.0016557 0.0007258188 0.2024766883 0.432719613 14 20990002 20990002 1 + 1.981 1.961 -0.068
ENSG00000165792 E008 207.0248371 0.0006473992 0.0740951158 0.232914111 14 20990003 20990029 27 + 2.323 2.303 -0.065
ENSG00000165792 E009 205.0655711 0.0006552026 0.0716798510 0.228187906 14 20990030 20990031 2 + 2.319 2.299 -0.066
ENSG00000165792 E010 207.1449342 0.0006130307 0.0608498791 0.204700864 14 20990032 20990035 4 + 2.324 2.303 -0.072
ENSG00000165792 E011 224.5971483 0.0030279947 0.1986438018 0.427969734 14 20990036 20990042 7 + 2.355 2.342 -0.043
ENSG00000165792 E012 233.6013973 0.0037180391 0.3746948669 0.607881373 14 20990043 20990047 5 + 2.365 2.365 0.000
ENSG00000165792 E013 281.0559562 0.0037374741 0.8113594454 0.903041963 14 20990048 20990077 30 + 2.431 2.456 0.085
ENSG00000165792 E014 36.7161755 0.0013438050 0.0557688680 0.193112910 14 20990078 20990229 152 + 1.617 1.533 -0.287
ENSG00000165792 E015 287.4997898 0.0022961430 0.7104012363 0.842040211 14 20990230 20990262 33 + 2.443 2.465 0.073
ENSG00000165792 E016 479.1026724 0.0069707998 0.5914728637 0.764696745 14 20990263 20990383 121 + 2.670 2.682 0.042
ENSG00000165792 E017 29.7187195 0.0444499149 0.0011239131 0.010848374 14 20990384 20990463 80 + 1.637 1.309 -1.129
ENSG00000165792 E018 473.7683111 0.0147078888 0.5314334742 0.723032397 14 20990464 20990546 83 + 2.674 2.671 -0.011
ENSG00000165792 E019 358.2669281 0.0128402842 0.3265044430 0.565714735 14 20990547 20990568 22 + 2.563 2.541 -0.073
ENSG00000165792 E020 286.8887797 0.0108882319 0.1147826925 0.307083529 14 20990569 20990575 7 + 2.483 2.431 -0.173
ENSG00000165792 E021 349.2468254 0.0110680806 0.1299158038 0.331700859 14 20990576 20990598 23 + 2.564 2.520 -0.148
ENSG00000165792 E022 2.8774178 0.0541485576 0.0014694601 0.013401435 14 20990599 20990732 134 + 0.812 0.268 -2.688
ENSG00000165792 E023 10.4161731 0.2785166042 0.0034119770 0.025834212 14 20991753 20992091 339 + 1.297 0.682 -2.303
ENSG00000165792 E024 87.5179546 0.0193153944 0.0415470934 0.158762796 14 20992092 20992123 32 + 2.000 1.893 -0.361
ENSG00000165792 E025 571.1764172 0.0115213142 0.2030194279 0.433366873 14 20992124 20992205 82 + 2.770 2.740 -0.100
ENSG00000165792 E026 15.1148067 0.1329001610 0.0188839728 0.092039518 14 20992206 20992304 99 + 1.364 1.023 -1.213
ENSG00000165792 E027 542.1162797 0.0129550871 0.2904766131 0.531135387 14 20992541 20992622 82 + 2.744 2.720 -0.078
ENSG00000165792 E028 76.9258587 0.1363442592 0.0006356345 0.006888663 14 20992623 20993116 494 + 2.097 1.608 -1.648
ENSG00000165792 E029 531.7544311 0.0082641892 0.5652571678 0.746876652 14 20993118 20993191 74 + 2.717 2.727 0.034
ENSG00000165792 E030 148.2178125 0.1346209152 0.0029278082 0.022967903 14 20993192 20993968 777 + 2.349 1.956 -1.315
ENSG00000165792 E031 589.3847184 0.0048186207 0.5059860192 0.704917749 14 20993969 20994063 95 + 2.760 2.773 0.044
ENSG00000165792 E032 524.7864877 0.0059158721 0.8375490269 0.918062388 14 20994543 20994613 71 + 2.701 2.728 0.091
ENSG00000165792 E033 455.3374893 0.0002188127 0.4316889758 0.652502606 14 20994794 20994847 54 + 2.646 2.661 0.048
ENSG00000165792 E034 497.4060530 0.0002945916 0.6139220204 0.779492504 14 20994848 20994901 54 + 2.671 2.708 0.123
ENSG00000165792 E035 137.5610209 0.0903287611 0.0220447078 0.102730323 14 20994902 20995116 215 + 2.247 2.030 -0.725
ENSG00000165792 E036 83.7728405 0.0893760521 0.0601763842 0.203243445 14 20995117 20995164 48 + 2.008 1.847 -0.541
ENSG00000165792 E037 533.9188749 0.0179544283 0.2279405094 0.462899899 14 20995165 20995233 69 + 2.670 2.763 0.310
ENSG00000165792 E038 341.4768562 1.4984304021 0.4935571922 0.696319307 14 20995901 20995929 29 + 2.407 2.606 0.662
ENSG00000165792 E039 350.2573506 1.5027171718 0.4886418154 0.693087047 14 20995930 20995951 22 + 2.413 2.619 0.687
ENSG00000165792 E040 74.0741878 0.9094155788 0.8111909594 0.902965256 14 20995952 20996208 257 + 1.880 1.865 -0.052
ENSG00000165792 E041 553.1811824 1.6485570322 0.4975358688 0.699200342 14 20996209 20996292 84 + 2.604 2.821 0.720
ENSG00000165792 E042 672.1452346 0.0566919348 0.0695117805 0.223801198 14 20996527 20996711 185 + 2.703 2.899 0.650
ENSG00000165792 E043 210.0101429 0.0052745658 0.0163302994 0.083011704 14 20996712 20996784 73 + 2.241 2.375 0.447
ENSG00000165792 E044 263.3536592 0.0514242822 0.0625776448 0.208558991 14 20996785 20996811 27 + 2.293 2.495 0.672
ENSG00000165792 E045 327.4626368 0.1070333146 0.1316439269 0.334403698 14 20996812 20996884 73 + 2.388 2.589 0.670
ENSG00000165792 E046 181.3885493 1.2575509362 0.4212127619 0.644550905 14 20996885 20997035 151 + 2.105 2.346 0.805
ENSG00000165792 E047 0.4341107 0.0226760838 0.1448962506   14 20998430 20998473 44 + 0.000 0.268 10.374