ENSG00000165704

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000298556 ENSG00000165704 HEK293_OSMI2_6hA HEK293_TMG_6hB HPRT1 protein_coding protein_coding 106.7576 53.79264 135.4166 11.05689 3.425207 1.331762 99.46592 47.16761 129.4706 10.69408 3.736855 1.456562 0.9171208 0.8660667 0.9559 0.08983333 0.005529573 1.659291e-07 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000165704 E001 0.3807181 0.0353175607 5.782959e-01   X 134460142 134460149 8 + 0.086 0.170 1.129
ENSG00000165704 E002 0.5233527 0.0212920451 1.000000e+00   X 134460150 134460150 1 + 0.157 0.170 0.129
ENSG00000165704 E003 2.6096807 0.0321422730 9.815670e-01 9.925785e-01 X 134460151 134460155 5 + 0.531 0.531 0.002
ENSG00000165704 E004 3.6388379 0.0078334340 6.460079e-01 8.008570e-01 X 134460156 134460163 8 + 0.653 0.587 -0.286
ENSG00000165704 E005 4.5959414 0.0063086249 7.018276e-01 8.367309e-01 X 134460164 134460164 1 + 0.730 0.683 -0.196
ENSG00000165704 E006 9.1637677 0.0086398179 7.892593e-02 2.426664e-01 X 134460165 134460172 8 + 0.903 1.111 0.769
ENSG00000165704 E007 363.1670659 0.0060564614 9.057755e-01 9.549953e-01 X 134460173 134460338 166 + 2.532 2.533 0.005
ENSG00000165704 E008 0.6791589 0.0195302685 4.561186e-01   X 134460339 134460350 12 + 0.157 0.291 1.130
ENSG00000165704 E009 0.7204775 0.1103269874 9.156967e-02   X 134460351 134460387 37 + 0.085 0.390 2.743
ENSG00000165704 E010 0.3150090 0.0384112028 5.736126e-01   X 134460388 134460535 148 + 0.086 0.169 1.130
ENSG00000165704 E011 0.2852693 0.3049297778 6.174399e-01   X 134467827 134467837 11 + 0.155 0.000 -9.888
ENSG00000165704 E012 0.4632531 0.0255332491 2.891817e-01   X 134467838 134467864 27 + 0.219 0.000 -11.578
ENSG00000165704 E013 265.5433813 0.0006364985 4.561319e-02 1.690639e-01 X 134473359 134473373 15 + 2.411 2.371 -0.132
ENSG00000165704 E014 519.4024857 0.0002310729 1.700438e-01 3.905087e-01 X 134473374 134473465 92 + 2.692 2.680 -0.040
ENSG00000165704 E015 937.9168065 0.0001223096 8.095335e-04 8.360413e-03 X 134475181 134475364 184 + 2.954 2.924 -0.100
ENSG00000165704 E016 694.7618875 0.0001136141 7.932798e-06 1.717455e-04 X 134486465 134486530 66 + 2.830 2.777 -0.176
ENSG00000165704 E017 497.4851755 0.0002636045 3.416470e-03 2.585886e-02 X 134490188 134490205 18 + 2.682 2.642 -0.134
ENSG00000165704 E018 736.8597190 0.0001823046 1.535400e-01 3.673875e-01 X 134493508 134493590 83 + 2.843 2.835 -0.028
ENSG00000165704 E019 572.5834374 0.0001524191 4.180633e-01 6.421908e-01 X 134498390 134498436 47 + 2.722 2.747 0.083
ENSG00000165704 E020 597.2997503 0.0001191855 3.002354e-01 5.406536e-01 X 134498608 134498684 77 + 2.739 2.767 0.092
ENSG00000165704 E021 1238.3496212 0.0050445510 4.658956e-01 6.772002e-01 X 134500030 134500668 639 + 3.051 3.087 0.118
ENSG00000165704 E022 25.4800767 0.0016125941 2.237059e-16 4.071856e-14 X 134513935 134514051 117 + 1.121 1.703 2.018
ENSG00000165704 E023 3.2569521 0.0105632697 5.059651e-01 7.049060e-01 X 134514639 134514698 60 + 0.631 0.529 -0.460
ENSG00000165704 E024 5.1197356 0.0051663779 6.874530e-06 1.515583e-04 X 134520482 134520625 144 + 0.472 1.078 2.479
ENSG00000165704 E025 2.1330454 0.0314601066 1.682493e-03 1.489727e-02 X 134520626 134520653 28 + 0.219 0.761 2.864
ENSG00000165704 E026 5.3293934 0.1205499886 5.029385e-02 1.803774e-01 X 134524119 134524248 130 + 0.611 1.000 1.547
ENSG00000165704 E027 9.4458427 0.0047162817 1.754944e-06 4.649451e-05 X 134524249 134524254 6 + 0.747 1.271 1.946
ENSG00000165704 E028 18.0138401 0.0516993295 2.721683e-06 6.827243e-05 X 134524255 134524338 84 + 0.952 1.567 2.175
ENSG00000165704 E029 22.6728978 0.0160871701 1.107689e-12 1.123629e-10 X 134524339 134524477 139 + 1.006 1.680 2.358
ENSG00000165704 E030 11.1215290 0.0676672579 8.021255e-07 2.344567e-05 X 134524766 134524861 96 + 0.654 1.417 2.840
ENSG00000165704 E031 16.7266402 0.2582186690 9.308046e-05 1.408716e-03 X 134525513 134525804 292 + 0.622 1.637 3.732
ENSG00000165704 E032 2.8617684 0.0379174641 6.312861e-09 3.090427e-07 X 134525805 134525809 5 + 0.000 0.980 14.386
ENSG00000165704 E033 6.4792844 0.0305018259 1.082037e-06 3.043178e-05 X 134525893 134526105 213 + 0.502 1.196 2.757