ENSG00000165699

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000403810 ENSG00000165699 HEK293_OSMI2_6hA HEK293_TMG_6hB TSC1 protein_coding protein_coding 11.2274 10.74708 12.71233 1.764582 0.6456997 0.2420765 0.2911388 0.0000000 0.7056795 0.0000000 0.3528957 6.16124165 0.02470833 0.00000000 0.05470000 0.054700000 0.31077127 0.01448908 FALSE TRUE
ENST00000440111 ENSG00000165699 HEK293_OSMI2_6hA HEK293_TMG_6hB TSC1 protein_coding protein_coding 11.2274 10.74708 12.71233 1.764582 0.6456997 0.2420765 3.1355501 2.7042986 5.4597747 0.5285193 0.2079155 1.01090194 0.27425000 0.25093333 0.43140000 0.180466667 0.01448908 0.01448908 FALSE TRUE
ENST00000642745 ENSG00000165699 HEK293_OSMI2_6hA HEK293_TMG_6hB TSC1 protein_coding protein_coding 11.2274 10.74708 12.71233 1.764582 0.6456997 0.2420765 1.0903471 1.7504310 0.7029844 0.2746496 0.7029844 -1.30398638 0.10161250 0.17296667 0.05783333 -0.115133333 0.29495667 0.01448908 FALSE TRUE
ENST00000644097 ENSG00000165699 HEK293_OSMI2_6hA HEK293_TMG_6hB TSC1 protein_coding protein_coding 11.2274 10.74708 12.71233 1.764582 0.6456997 0.2420765 0.6006846 0.4584064 0.7082287 0.2164899 0.3933694 0.61668253 0.05328333 0.05336667 0.05550000 0.002133333 1.00000000 0.01448908 FALSE TRUE
ENST00000644786 ENSG00000165699 HEK293_OSMI2_6hA HEK293_TMG_6hB TSC1 protein_coding processed_transcript 11.2274 10.74708 12.71233 1.764582 0.6456997 0.2420765 1.8580114 2.8405835 0.4354671 0.8156695 0.2179304 -2.67786634 0.17065833 0.25606667 0.03610000 -0.219966667 0.20368437 0.01448908 FALSE TRUE
ENST00000645150 ENSG00000165699 HEK293_OSMI2_6hA HEK293_TMG_6hB TSC1 protein_coding protein_coding 11.2274 10.74708 12.71233 1.764582 0.6456997 0.2420765 1.1885954 1.0458308 1.1207917 0.5883518 0.5699103 0.09895453 0.10463333 0.08316667 0.08606667 0.002900000 1.00000000 0.01448908 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000165699 E001 0.0000000       9 132891348 132891348 1 -      
ENSG00000165699 E002 0.0000000       9 132891349 132891349 1 -      
ENSG00000165699 E003 1.9722499 0.010864776 8.683606e-02 2.579386e-01 9 132891350 132891352 3 - 0.276 0.620 1.834
ENSG00000165699 E004 2.5372287 0.009175961 1.221794e-02 6.732274e-02 9 132891353 132891374 22 - 0.276 0.745 2.362
ENSG00000165699 E005 9.4030171 0.012763176 1.915916e-04 2.581455e-03 9 132891375 132891389 15 - 0.711 1.232 1.958
ENSG00000165699 E006 9.5753915 0.008249910 7.254242e-05 1.143435e-03 9 132891390 132891391 2 - 0.711 1.242 1.991
ENSG00000165699 E007 404.9686310 1.478306387 3.746096e-01 6.078185e-01 9 132891392 132893352 1961 - 2.416 2.757 1.137
ENSG00000165699 E008 224.5551577 1.293129242 4.281417e-01 6.495424e-01 9 132893353 132894777 1425 - 2.216 2.470 0.845
ENSG00000165699 E009 22.1580712 0.247905413 3.275526e-01 5.666179e-01 9 132894778 132894848 71 - 1.263 1.459 0.681
ENSG00000165699 E010 53.3846710 0.557795322 3.570782e-01 5.933415e-01 9 132894849 132895077 229 - 1.637 1.826 0.638
ENSG00000165699 E011 137.6652330 1.161412777 5.053209e-01 7.045286e-01 9 132895078 132895911 834 - 2.063 2.216 0.512
ENSG00000165699 E012 39.3802232 0.443569975 3.269729e-01 5.661123e-01 9 132895912 132895977 66 - 1.502 1.701 0.677
ENSG00000165699 E013 29.4191020 0.366006267 3.775391e-01 6.102744e-01 9 132895978 132895998 21 - 1.401 1.561 0.549
ENSG00000165699 E014 42.1189803 0.436633757 2.491841e-01 4.869642e-01 9 132895999 132896087 89 - 1.494 1.754 0.885
ENSG00000165699 E015 40.7387255 0.407727265 2.043504e-01 4.350541e-01 9 132896088 132896166 79 - 1.459 1.753 1.001
ENSG00000165699 E016 31.6295449 0.364330208 3.010776e-01 5.415385e-01 9 132896167 132896197 31 - 1.400 1.615 0.740
ENSG00000165699 E017 84.6673938 0.716206100 3.893517e-01 6.199664e-01 9 132896198 132896540 343 - 1.836 2.021 0.621
ENSG00000165699 E018 15.9427241 0.178271893 4.899026e-01 6.939298e-01 9 132896541 132896541 1 - 1.170 1.289 0.422
ENSG00000165699 E019 47.8072113 0.529149111 3.836430e-01 6.152650e-01 9 132896542 132896754 213 - 1.598 1.773 0.593
ENSG00000165699 E020 40.7610777 0.478135680 3.873684e-01 6.184050e-01 9 132897184 132897345 162 - 1.526 1.708 0.617
ENSG00000165699 E021 1.6312005 0.099177159 5.554903e-01 7.401264e-01 9 132897346 132897422 77 - 0.338 0.496 0.855
ENSG00000165699 E022 18.6916281 0.214222697 3.657750e-01 6.005763e-01 9 132897423 132897427 5 - 1.198 1.385 0.655
ENSG00000165699 E023 48.9587763 0.353550161 4.064689e-01 6.333926e-01 9 132897428 132897610 183 - 1.624 1.771 0.498
ENSG00000165699 E024 0.9694175 0.038423304 4.239285e-01   9 132898980 132900714 1735 - 0.339 0.232 -0.747
ENSG00000165699 E025 46.1972057 0.001005775 5.361121e-01 7.263949e-01 9 132900715 132900837 123 - 1.624 1.736 0.378
ENSG00000165699 E026 31.4714299 0.007695805 9.281502e-01 9.660888e-01 9 132901589 132901630 42 - 1.476 1.557 0.276
ENSG00000165699 E027 44.5753459 0.003960271 1.242181e-01 3.223972e-01 9 132901631 132901699 69 - 1.665 1.659 -0.020
ENSG00000165699 E028 0.0000000       9 132901909 132901958 50 -      
ENSG00000165699 E029 61.5473043 0.016860125 1.720097e-01 3.932170e-01 9 132902605 132902783 179 - 1.798 1.792 -0.019
ENSG00000165699 E030 20.7827819 0.030653292 1.690621e-01 3.893707e-01 9 132902784 132902787 4 - 1.361 1.307 -0.187
ENSG00000165699 E031 46.7778018 0.037835090 8.463242e-02 2.540158e-01 9 132903651 132903802 152 - 1.714 1.633 -0.273
ENSG00000165699 E032 20.1071300 0.013737901 2.081037e-03 1.760964e-02 9 132903803 132903817 15 - 1.412 1.213 -0.695
ENSG00000165699 E033 26.7712884 0.001342674 2.386807e-05 4.440078e-04 9 132904411 132904454 44 - 1.533 1.323 -0.725
ENSG00000165699 E034 102.5722240 0.032423631 6.854619e-03 4.396867e-02 9 132905581 132906139 559 - 2.076 1.930 -0.491
ENSG00000165699 E035 1.2868997 0.013908512 1.747775e-03   9 132906140 132906542 403 - 0.527 0.000 -22.229
ENSG00000165699 E036 19.7558759 0.018680924 1.209060e-02 6.682058e-02 9 132906731 132906743 13 - 1.382 1.225 -0.548
ENSG00000165699 E037 16.4368641 0.047120243 3.753687e-02 1.484127e-01 9 132906744 132906750 7 - 1.314 1.141 -0.612
ENSG00000165699 E038 30.3080943 0.045675905 2.502292e-02 1.122831e-01 9 132906751 132906835 85 - 1.566 1.391 -0.602
ENSG00000165699 E039 31.1299556 0.048032007 1.516924e-02 7.872402e-02 9 132907301 132907370 70 - 1.586 1.383 -0.699
ENSG00000165699 E040 0.7794795 0.017133643 1.778249e-01   9 132909752 132909806 55 - 0.113 0.381 2.248
ENSG00000165699 E041 36.0280243 0.001178798 3.952981e-09 2.025508e-07 9 132909807 132910260 454 - 1.312 1.752 1.507
ENSG00000165699 E042 34.7261947 0.013618944 8.325065e-03 5.081424e-02 9 132910261 132910570 310 - 1.376 1.684 1.055
ENSG00000165699 E043 46.8182118 0.059323449 3.691522e-01 6.033827e-01 9 132910571 132910636 66 - 1.682 1.669 -0.043
ENSG00000165699 E044 45.7666372 0.059486060 2.814596e-01 5.217758e-01 9 132910637 132910689 53 - 1.685 1.648 -0.127
ENSG00000165699 E045 23.1877847 0.061724410 4.021087e-01 6.301096e-01 9 132910690 132910692 3 - 1.386 1.373 -0.045
ENSG00000165699 E046 7.7360188 0.056130838 4.803214e-01 6.872956e-01 9 132910693 132910998 306 - 0.941 0.914 -0.100
ENSG00000165699 E047 1.8044553 0.011313180 1.258027e-01 3.251582e-01 9 132910999 132911001 3 - 0.527 0.313 -1.165
ENSG00000165699 E048 63.7062523 0.054005628 1.359432e-01 3.412252e-01 9 132911002 132911113 112 - 1.842 1.768 -0.249
ENSG00000165699 E049 8.6094920 0.099380912 7.889637e-03 4.881382e-02 9 132911114 132911290 177 - 1.118 0.724 -1.496
ENSG00000165699 E050 8.8858209 0.145103033 6.608873e-02 2.162909e-01 9 132911291 132911409 119 - 1.103 0.819 -1.059
ENSG00000165699 E051 5.9952315 0.110527273 1.221441e-01 3.192558e-01 9 132911410 132911452 43 - 0.926 0.718 -0.815
ENSG00000165699 E052 51.4939502 0.011705922 2.449203e-02 1.106405e-01 9 132911453 132911507 55 - 1.751 1.683 -0.231
ENSG00000165699 E053 50.6719986 0.048711142 1.014193e-01 2.844010e-01 9 132911508 132911568 61 - 1.752 1.661 -0.309
ENSG00000165699 E054 79.0761381 0.046970268 4.793414e-02 1.748624e-01 9 132912282 132912457 176 - 1.953 1.837 -0.389
ENSG00000165699 E055 0.5227326 0.585378529 7.626153e-01   9 132912458 132912921 464 - 0.114 0.235 1.253
ENSG00000165699 E056 53.9709222 0.039679416 5.121684e-02 1.826232e-01 9 132921363 132921425 63 - 1.783 1.681 -0.347
ENSG00000165699 E057 38.6573650 0.051066578 4.112975e-02 1.576841e-01 9 132921426 132921436 11 - 1.657 1.515 -0.485
ENSG00000165699 E058 65.5888617 0.020038178 2.812724e-02 1.216269e-01 9 132921819 132921940 122 - 1.855 1.782 -0.244
ENSG00000165699 E059 39.0133634 0.015387339 3.201125e-01 5.598548e-01 9 132921941 132921973 33 - 1.595 1.608 0.046
ENSG00000165699 E060 59.0710451 0.054544217 3.624164e-01 5.976620e-01 9 132923348 132923479 132 - 1.780 1.773 -0.025
ENSG00000165699 E061 28.8779395 0.097076105 2.959161e-01 5.364078e-01 9 132923480 132923492 13 - 1.505 1.430 -0.257
ENSG00000165699 E062 3.4551202 0.070720002 8.289960e-01 9.132593e-01 9 132923493 132923684 192 - 0.598 0.714 0.493
ENSG00000165699 E063 0.9121510 0.017267182 8.137074e-03   9 132924815 132924906 92 - 0.443 0.000 -21.812
ENSG00000165699 E064 0.7860845 0.017059898 1.672833e-02   9 132924907 132924939 33 - 0.394 0.000 -21.550
ENSG00000165699 E065 1.1550361 0.014981709 2.453624e-01   9 132924940 132925007 68 - 0.395 0.231 -1.075
ENSG00000165699 E066 58.1409626 0.024999295 1.137042e-01 3.053004e-01 9 132925587 132925734 148 - 1.786 1.748 -0.128
ENSG00000165699 E067 27.5775231 0.001466461 1.754366e-03 1.539619e-02 9 132925735 132925739 5 - 1.514 1.384 -0.449
ENSG00000165699 E068 1.9414805 0.010348921 2.471880e-01 4.848932e-01 9 132925740 132927200 1461 - 0.527 0.382 -0.749
ENSG00000165699 E069 49.5053812 0.018657217 6.804011e-03 4.370849e-02 9 132927201 132927304 104 - 1.754 1.633 -0.410
ENSG00000165699 E070 59.4749739 0.022696238 1.891431e-01 4.159008e-01 9 132928767 132928952 186 - 1.792 1.774 -0.061
ENSG00000165699 E071 0.3040503 0.024441170 1.976940e-01   9 132928953 132928955 3 - 0.202 0.000 -20.228
ENSG00000165699 E072 0.9997774 0.016104151 4.101095e-01   9 132931209 132931304 96 - 0.339 0.232 -0.749
ENSG00000165699 E073 1.3439786 0.080143845 4.714522e-01   9 132931305 132931427 123 - 0.396 0.313 -0.494
ENSG00000165699 E074 0.2922838 0.026045723 1.000000e+00   9 132934466 132934540 75 - 0.113 0.131 0.245
ENSG00000165699 E075 30.1115477 0.038510141 7.323321e-01 8.556360e-01 9 132935033 132935095 63 - 1.475 1.525 0.172
ENSG00000165699 E076 0.7260870 0.175504774 9.563814e-01   9 132939071 132939276 206 - 0.202 0.236 0.283
ENSG00000165699 E077 0.5963342 0.021768165 3.099459e-01   9 132940735 132941395 661 - 0.276 0.131 -1.338
ENSG00000165699 E078 0.1426347 0.030905768 4.760897e-01   9 132941396 132941419 24 - 0.112 0.000 -19.227
ENSG00000165699 E079 0.2852693 0.137779766 2.296290e-01   9 132941420 132941492 73 - 0.200 0.000 -20.216
ENSG00000165699 E080 1.4630306 0.017750877 9.137259e-02 2.662246e-01 9 132941493 132942214 722 - 0.487 0.232 -1.555
ENSG00000165699 E081 0.8322047 0.078762569 6.299183e-01   9 132942215 132942426 212 - 0.277 0.231 -0.340
ENSG00000165699 E082 1.7710747 0.097481536 7.531473e-01 8.686262e-01 9 132943468 132943654 187 - 0.444 0.440 -0.016
ENSG00000165699 E083 1.4451070 0.052009732 3.071473e-01 5.477624e-01 9 132943655 132943706 52 - 0.444 0.312 -0.760
ENSG00000165699 E084 10.8242311 0.056440541 5.355906e-01 7.260139e-01 9 132944543 132944546 4 - 1.001 1.166 0.597
ENSG00000165699 E085 11.2229926 0.084444871 4.474378e-01 6.638526e-01 9 132944547 132944571 25 - 0.999 1.192 0.698
ENSG00000165699 E086 16.7150329 0.225297659 4.883570e-01 6.928803e-01 9 132944572 132944834 263 - 1.189 1.313 0.436
ENSG00000165699 E087 0.0000000       9 132945185 132945375 191 -      
ENSG00000165699 E088 0.0000000       9 132946759 132946874 116 -