ENSG00000165689

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000298537 ENSG00000165689 HEK293_OSMI2_6hA HEK293_TMG_6hB ENTR1 protein_coding protein_coding 89.60457 101.5354 73.79612 6.862677 0.9433932 -0.4603129 18.968390 20.502308 14.684891 2.2173665 1.4121685 -0.48117517 0.21225417 0.20600000 0.19863333 -0.007366667 1.00000000 0.04530828 FALSE  
ENST00000357365 ENSG00000165689 HEK293_OSMI2_6hA HEK293_TMG_6hB ENTR1 protein_coding protein_coding 89.60457 101.5354 73.79612 6.862677 0.9433932 -0.4603129 5.452005 7.078700 3.913388 0.3956543 0.7582969 -0.85342131 0.05872917 0.07073333 0.05326667 -0.017466667 0.74070017 0.04530828 FALSE  
ENST00000371725 ENSG00000165689 HEK293_OSMI2_6hA HEK293_TMG_6hB ENTR1 protein_coding protein_coding 89.60457 101.5354 73.79612 6.862677 0.9433932 -0.4603129 19.915697 22.501446 9.782461 1.0963328 0.1341964 -1.20091528 0.21737083 0.22423333 0.13263333 -0.091600000 0.04530828 0.04530828 FALSE  
ENST00000461693 ENSG00000165689 HEK293_OSMI2_6hA HEK293_TMG_6hB ENTR1 protein_coding processed_transcript 89.60457 101.5354 73.79612 6.862677 0.9433932 -0.4603129 14.702098 16.198280 15.213488 2.6663554 1.3933722 -0.09043207 0.16619167 0.15756667 0.20620000 0.048633333 0.59200538 0.04530828 FALSE  
ENST00000466579 ENSG00000165689 HEK293_OSMI2_6hA HEK293_TMG_6hB ENTR1 protein_coding processed_transcript 89.60457 101.5354 73.79612 6.862677 0.9433932 -0.4603129 8.728549 8.488569 8.636822 4.2263620 0.7237503 0.02495008 0.09742500 0.07923333 0.11706667 0.037833333 0.69642171 0.04530828    
ENST00000486441 ENSG00000165689 HEK293_OSMI2_6hA HEK293_TMG_6hB ENTR1 protein_coding processed_transcript 89.60457 101.5354 73.79612 6.862677 0.9433932 -0.4603129 3.932812 3.710452 7.057870 2.3696375 1.9555784 0.92579741 0.04604583 0.03426667 0.09566667 0.061400000 0.71494395 0.04530828 TRUE  
MSTRG.33630.5 ENSG00000165689 HEK293_OSMI2_6hA HEK293_TMG_6hB ENTR1 protein_coding   89.60457 101.5354 73.79612 6.862677 0.9433932 -0.4603129 5.736466 6.397050 3.929884 0.6205891 0.5248328 -0.70150707 0.06564167 0.06420000 0.05333333 -0.010866667 0.87310879 0.04530828 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000165689 E001 4.703293 0.0471627698 0.27357917 0.51343197 9 136401922 136401924 3 - 0.594 0.781 0.783
ENSG00000165689 E002 14.215906 0.0863636695 0.05466959 0.19059045 9 136401925 136401950 26 - 0.914 1.220 1.114
ENSG00000165689 E003 624.531091 1.4998974851 0.49112003 0.69474372 9 136401951 136402479 529 - 2.653 2.794 0.470
ENSG00000165689 E004 476.758722 1.4208461181 0.50906649 0.70720198 9 136402480 136402643 164 - 2.557 2.671 0.379
ENSG00000165689 E005 268.645168 1.2324160773 0.52105552 0.71559778 9 136402644 136402664 21 - 2.336 2.413 0.258
ENSG00000165689 E006 261.890640 1.2203042965 0.51500944 0.71165595 9 136402665 136402681 17 - 2.321 2.403 0.275
ENSG00000165689 E007 586.332538 1.4774265918 0.48850335 0.69299483 9 136402682 136402887 206 - 2.625 2.767 0.471
ENSG00000165689 E008 12.581245 0.2297564416 0.47950561 0.68682592 9 136404013 136404054 42 - 1.122 1.087 -0.125
ENSG00000165689 E009 328.891660 0.0213317228 0.03780715 0.14909604 9 136404055 136404109 55 - 2.386 2.514 0.427
ENSG00000165689 E010 420.502491 0.0001697990 0.01025503 0.05921594 9 136404110 136404194 85 - 2.551 2.599 0.159
ENSG00000165689 E011 433.356850 0.0199222557 0.58594673 0.76091934 9 136404631 136404693 63 - 2.609 2.594 -0.052
ENSG00000165689 E012 58.012709 0.1125798708 0.03711838 0.14723114 9 136404694 136404780 87 - 1.902 1.635 -0.903
ENSG00000165689 E013 342.550035 0.0359710106 0.24675593 0.48444445 9 136405091 136405117 27 - 2.554 2.470 -0.283
ENSG00000165689 E014 563.634568 0.0458865339 0.23517064 0.47109304 9 136405118 136405202 85 - 2.777 2.682 -0.316
ENSG00000165689 E015 99.297054 0.0914081162 0.03349761 0.13746515 9 136405203 136405348 146 - 2.133 1.864 -0.903
ENSG00000165689 E016 430.632825 0.0415021393 0.24973035 0.48756941 9 136405905 136405978 74 - 2.657 2.567 -0.299
ENSG00000165689 E017 117.138404 0.0790566494 0.05530374 0.19201192 9 136406946 136407016 71 - 2.170 1.960 -0.703
ENSG00000165689 E018 143.360179 0.0779436827 0.03273316 0.13530764 9 136407017 136407144 128 - 2.273 2.035 -0.797
ENSG00000165689 E019 958.008968 0.0263548908 0.22239597 0.45634961 9 136407145 136407561 417 - 2.986 2.923 -0.209
ENSG00000165689 E020 278.492704 0.0036202759 0.09583820 0.27448404 9 136407826 136407874 49 - 2.443 2.391 -0.173
ENSG00000165689 E021 255.047158 0.0002290033 0.94860865 0.97655631 9 136407875 136407938 64 - 2.372 2.368 -0.012
ENSG00000165689 E022 7.776187 0.0969178562 0.98598127 0.99482198 9 136407939 136407966 28 - 0.867 0.922 0.206
ENSG00000165689 E023 50.716843 0.0148075394 0.98651715 0.99511334 9 136408999 136409067 69 - 1.660 1.678 0.062
ENSG00000165689 E024 30.906229 0.3185308649 0.62966733 0.79027734 9 136409874 136410089 216 - 1.452 1.472 0.070
ENSG00000165689 E025 175.735796 1.0640672147 0.48935120 0.69355451 9 136410090 136410201 112 - 2.145 2.232 0.290
ENSG00000165689 E026 82.667893 0.5460639206 0.38853389 0.61928953 9 136410202 136410239 38 - 1.816 1.910 0.314
ENSG00000165689 E027 35.231881 0.2619034628 0.37913193 0.61150606 9 136410240 136410327 88 - 1.462 1.545 0.282
ENSG00000165689 E028 111.534499 0.4752646523 0.11540874 0.30814677 9 136410328 136410614 287 - 1.740 2.090 1.179