ENSG00000165671

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000347982 ENSG00000165671 HEK293_OSMI2_6hA HEK293_TMG_6hB NSD1 protein_coding protein_coding 25.57554 28.37945 24.89016 5.536458 1.605488 -0.1891995 2.358452 1.374255 6.455077 1.3742545 1.5453289 2.2235584 0.08942500 0.04436667 0.25490000 0.21053333 1.631764e-01 1.845969e-46 FALSE TRUE
ENST00000439151 ENSG00000165671 HEK293_OSMI2_6hA HEK293_TMG_6hB NSD1 protein_coding protein_coding 25.57554 28.37945 24.89016 5.536458 1.605488 -0.1891995 1.384663 1.068354 2.077867 0.1004851 0.6333178 0.9531994 0.05345000 0.03953333 0.08263333 0.04310000 5.833521e-01 1.845969e-46 FALSE TRUE
ENST00000503056 ENSG00000165671 HEK293_OSMI2_6hA HEK293_TMG_6hB NSD1 protein_coding protein_coding 25.57554 28.37945 24.89016 5.536458 1.605488 -0.1891995 6.076347 13.761277 0.000000 3.2017769 0.0000000 -10.4274467 0.25722500 0.47726667 0.00000000 -0.47726667 1.845969e-46 1.845969e-46 FALSE TRUE
ENST00000686993 ENSG00000165671 HEK293_OSMI2_6hA HEK293_TMG_6hB NSD1 protein_coding protein_coding 25.57554 28.37945 24.89016 5.536458 1.605488 -0.1891995 6.268077 4.601801 7.987631 1.5381534 1.6436788 0.7942424 0.23642083 0.16243333 0.32983333 0.16740000 4.427090e-01 1.845969e-46 FALSE TRUE
ENST00000689345 ENSG00000165671 HEK293_OSMI2_6hA HEK293_TMG_6hB NSD1 protein_coding protein_coding 25.57554 28.37945 24.89016 5.536458 1.605488 -0.1891995 4.781885 4.992534 3.337205 1.0468121 0.8591905 -0.5797021 0.18389167 0.17450000 0.13226667 -0.04223333 7.582599e-01 1.845969e-46 FALSE TRUE
MSTRG.27376.8 ENSG00000165671 HEK293_OSMI2_6hA HEK293_TMG_6hB NSD1 protein_coding   25.57554 28.37945 24.89016 5.536458 1.605488 -0.1891995 1.396790 0.921917 1.551668 0.1425616 0.3119980 0.7448149 0.05039583 0.03330000 0.06190000 0.02860000 3.655089e-01 1.845969e-46 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000165671 E001 0.0000000       5 177131830 177131934 105 +      
ENSG00000165671 E002 0.0000000       5 177133025 177133078 54 +      
ENSG00000165671 E003 0.0000000       5 177133079 177133154 76 +      
ENSG00000165671 E004 4.7760165 0.0459925475 1.055909e-01 2.916445e-01 5 177133600 177133634 35 + 0.858 0.625 -0.949
ENSG00000165671 E005 0.5963342 0.0208023284 2.596090e-01   5 177133754 177133767 14 + 0.297 0.120 -1.628
ENSG00000165671 E006 0.7272023 0.0386766946 5.609811e-01   5 177133768 177133772 5 + 0.297 0.213 -0.633
ENSG00000165671 E007 0.7272023 0.0386766946 5.609811e-01   5 177133773 177133774 2 + 0.297 0.213 -0.633
ENSG00000165671 E008 5.8953411 0.0345592100 6.056823e-02 2.041213e-01 5 177133775 177133797 23 + 0.661 0.977 1.244
ENSG00000165671 E009 13.9558053 0.1862769506 9.032152e-02 2.643440e-01 5 177133798 177133853 56 + 0.955 1.317 1.300
ENSG00000165671 E010 15.5169430 0.2815359125 2.391504e-01 4.756149e-01 5 177133854 177133899 46 + 1.073 1.324 0.891
ENSG00000165671 E011 17.7689205 0.3384896113 2.933658e-01 5.340684e-01 5 177133900 177133952 53 + 1.146 1.368 0.783
ENSG00000165671 E012 2.0521396 0.0340275706 5.527153e-01 7.381952e-01 5 177134170 177134172 3 + 0.420 0.549 0.639
ENSG00000165671 E013 4.9405000 0.0718898712 3.921562e-01 6.221416e-01 5 177134173 177134228 56 + 0.836 0.712 -0.496
ENSG00000165671 E014 4.1727870 0.1972999722 1.681388e-01 3.881046e-01 5 177134229 177134245 17 + 0.834 0.556 -1.164
ENSG00000165671 E015 1.3383691 0.0136968632 8.640148e-01   5 177135086 177135086 1 + 0.364 0.357 -0.041
ENSG00000165671 E016 45.9885858 0.0088794856 5.844628e-02 1.992957e-01 5 177135087 177135135 49 + 1.720 1.626 -0.317
ENSG00000165671 E017 53.5761753 0.0009719536 5.924833e-03 3.937130e-02 5 177135136 177135166 31 + 1.782 1.688 -0.319
ENSG00000165671 E018 59.9379862 0.0033871193 6.733143e-05 1.073958e-03 5 177135167 177135200 34 + 1.863 1.691 -0.581
ENSG00000165671 E019 10.3248073 0.0044965569 1.116981e-03 1.079644e-02 5 177135201 177135286 86 + 1.178 0.868 -1.143
ENSG00000165671 E020 20.0574864 0.0020641531 1.124616e-06 3.144832e-05 5 177135287 177135520 234 + 1.465 1.117 -1.221
ENSG00000165671 E021 27.3749396 0.0018524175 8.318536e-08 3.149083e-06 5 177135521 177135940 420 + 1.591 1.259 -1.146
ENSG00000165671 E022 84.6435861 0.0004712234 4.243331e-15 6.551048e-13 5 177135941 177136030 90 + 2.048 1.779 -0.902
ENSG00000165671 E023 2.0203611 0.0128674848 4.410141e-01 6.594786e-01 5 177136031 177136345 315 + 0.517 0.414 -0.523
ENSG00000165671 E024 9.3807462 0.1388948587 6.609942e-01 8.105482e-01 5 177136873 177137404 532 + 0.958 1.049 0.335
ENSG00000165671 E025 2.4493102 0.0122856979 1.344038e-01 3.387332e-01 5 177169394 177169428 35 + 0.631 0.413 -1.041
ENSG00000165671 E026 2.3556424 0.0093047534 6.196374e-01 7.835753e-01 5 177169429 177169559 131 + 0.559 0.508 -0.236
ENSG00000165671 E027 0.4868358 0.2802248641 5.564033e-01   5 177169560 177169644 85 + 0.222 0.118 -1.093
ENSG00000165671 E028 2.6050598 0.2038339731 5.732561e-01 7.525144e-01 5 177187126 177187480 355 + 0.600 0.508 -0.424
ENSG00000165671 E029 115.3707720 0.0009843565 2.841097e-22 1.096554e-19 5 177191884 177192019 136 + 2.200 1.888 -1.045
ENSG00000165671 E030 143.3917760 0.0028876360 1.099315e-17 2.396521e-15 5 177204120 177204292 173 + 2.290 1.990 -1.001
ENSG00000165671 E031 1191.4580586 0.0023120372 7.530369e-28 5.241106e-25 5 177209636 177212110 2475 + 3.173 2.960 -0.709
ENSG00000165671 E032 115.3612892 0.0003637420 1.410544e-03 1.297527e-02 5 177212111 177212195 85 + 2.098 2.034 -0.215
ENSG00000165671 E033 0.1723744 0.0469154212 5.378522e-01   5 177229765 177229886 122 + 0.000 0.120 11.621
ENSG00000165671 E034 126.0294392 0.0005000662 1.382349e-04 1.960045e-03 5 177235821 177235945 125 + 2.145 2.063 -0.274
ENSG00000165671 E035 191.1107648 0.0004722589 3.483613e-07 1.126423e-05 5 177238237 177238507 271 + 2.329 2.235 -0.316
ENSG00000165671 E036 0.8995767 0.0175820838 8.788186e-01   5 177238508 177239205 698 + 0.297 0.291 -0.043
ENSG00000165671 E037 149.4324404 0.0003371835 9.927783e-05 1.485040e-03 5 177239756 177239865 110 + 2.211 2.139 -0.242
ENSG00000165671 E038 119.0672671 0.0003403548 2.550974e-03 2.066368e-02 5 177244195 177244270 76 + 2.105 2.048 -0.191
ENSG00000165671 E039 156.3149936 0.0003326180 9.430342e-05 1.423677e-03 5 177246678 177246796 119 + 2.230 2.160 -0.236
ENSG00000165671 E040 143.8726873 0.0025426084 1.020899e-01 2.855177e-01 5 177248181 177248324 144 + 2.169 2.150 -0.061
ENSG00000165671 E041 126.7720056 0.0014794913 6.976921e-01 8.340372e-01 5 177251730 177251853 124 + 2.072 2.130 0.197
ENSG00000165671 E042 2.9882650 0.0484100806 2.131488e-02 1.003671e-01 5 177253980 177254072 93 + 0.298 0.742 2.198
ENSG00000165671 E043 171.6847478 0.0016716919 7.565945e-01 8.705813e-01 5 177256951 177257151 201 + 2.217 2.252 0.119
ENSG00000165671 E044 178.7589807 0.0003685159 1.180903e-01 3.127327e-01 5 177259989 177260168 180 + 2.252 2.252 -0.001
ENSG00000165671 E045 0.4654660 0.0241124501 6.845496e-02   5 177265465 177265496 32 + 0.297 0.000 -14.101
ENSG00000165671 E046 0.7990684 0.0172671820 5.606995e-01   5 177265497 177265711 215 + 0.297 0.214 -0.625
ENSG00000165671 E047 0.1308682 0.0326491905 5.408765e-01   5 177265712 177265726 15 + 0.000 0.120 11.743
ENSG00000165671 E048 0.5059767 0.0215813302 1.045755e-01   5 177265727 177265809 83 + 0.000 0.291 13.469
ENSG00000165671 E049 2.0643157 0.0240982151 2.794164e-03 2.214868e-02 5 177265810 177266336 527 + 0.123 0.682 3.543
ENSG00000165671 E050 0.6368449 0.0190131618 4.960939e-02   5 177266337 177266379 43 + 0.000 0.356 13.921
ENSG00000165671 E051 0.8507255 0.1087829119 3.089810e-02   5 177266380 177266556 177 + 0.000 0.416 13.655
ENSG00000165671 E052 0.1723744 0.0469154212 5.378522e-01   5 177266557 177266586 30 + 0.000 0.120 11.621
ENSG00000165671 E053 0.1723744 0.0469154212 5.378522e-01   5 177266587 177266657 71 + 0.000 0.120 11.621
ENSG00000165671 E054 0.1723744 0.0469154212 5.378522e-01   5 177266658 177266671 14 + 0.000 0.120 11.621
ENSG00000165671 E055 0.3447487 0.7097252291 4.031924e-01   5 177266672 177266729 58 + 0.000 0.218 11.808
ENSG00000165671 E056 1.5484778 0.0133770055 2.255679e-02 1.044232e-01 5 177266730 177267561 832 + 0.123 0.550 2.962
ENSG00000165671 E057 180.4807429 0.0002924984 1.921162e-01 4.195266e-01 5 177267562 177267718 157 + 2.254 2.261 0.024
ENSG00000165671 E058 209.7564578 0.0006902820 1.218712e-01 3.188594e-01 5 177269602 177269807 206 + 2.323 2.322 -0.002
ENSG00000165671 E059 144.3148125 0.0036318466 6.299358e-01 7.903910e-01 5 177273672 177273784 113 + 2.153 2.172 0.061
ENSG00000165671 E060 208.4860221 0.0003962300 6.067642e-01 7.747142e-01 5 177280565 177280834 270 + 2.304 2.333 0.096
ENSG00000165671 E061 3.3871350 0.0115142433 1.891003e-01 4.158389e-01 5 177280835 177282464 1630 + 0.720 0.550 -0.736
ENSG00000165671 E062 157.0593085 0.0002846573 5.255856e-01 7.189005e-01 5 177282465 177282581 117 + 2.183 2.208 0.082
ENSG00000165671 E063 204.9591041 0.0002359802 6.431654e-01 7.989370e-01 5 177283787 177283928 142 + 2.283 2.337 0.181
ENSG00000165671 E064 2.5930559 0.0881906599 3.307447e-01 5.696961e-01 5 177283929 177285364 1436 + 0.629 0.466 -0.760
ENSG00000165671 E065 1.4475075 0.0147632518 6.313091e-02 2.097536e-01 5 177288526 177288818 293 + 0.518 0.214 -1.851
ENSG00000165671 E066 211.1580213 0.0013380728 5.305998e-01 7.224524e-01 5 177288819 177288925 107 + 2.313 2.336 0.077
ENSG00000165671 E067 1.8432483 0.0317788468 7.388096e-01 8.596925e-01 5 177291280 177291953 674 + 0.421 0.507 0.435
ENSG00000165671 E068 303.0682866 0.0002955868 7.918494e-01 8.915165e-01 5 177291954 177292158 205 + 2.454 2.503 0.162
ENSG00000165671 E069 4034.2998527 0.0007590630 2.106068e-65 1.882414e-61 5 177293832 177300213 6382 + 3.494 3.690 0.651