ENSG00000165660

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000298492 ENSG00000165660 HEK293_OSMI2_6hA HEK293_TMG_6hB ABRAXAS2 protein_coding protein_coding 15.22145 4.847802 26.1315 1.38462 0.8957222 2.427967 10.8247482 4.5356517 17.886019 1.2654755 1.494975 1.977080 0.78610417 0.93983333 0.68253333 -0.25730000 2.188677e-04 1.039479e-05 FALSE TRUE
MSTRG.4777.3 ENSG00000165660 HEK293_OSMI2_6hA HEK293_TMG_6hB ABRAXAS2 protein_coding   15.22145 4.847802 26.1315 1.38462 0.8957222 2.427967 0.4198708 0.0000000 1.812478 0.0000000 1.347707 7.509758 0.02938750 0.00000000 0.07133333 0.07133333 5.978733e-01 1.039479e-05 FALSE TRUE
MSTRG.4777.4 ENSG00000165660 HEK293_OSMI2_6hA HEK293_TMG_6hB ABRAXAS2 protein_coding   15.22145 4.847802 26.1315 1.38462 0.8957222 2.427967 1.8815619 0.1809793 2.383728 0.1296959 1.436762 3.647771 0.09564167 0.03876667 0.09236667 0.05360000 9.686790e-01 1.039479e-05 FALSE TRUE
MSTRG.4777.5 ENSG00000165660 HEK293_OSMI2_6hA HEK293_TMG_6hB ABRAXAS2 protein_coding   15.22145 4.847802 26.1315 1.38462 0.8957222 2.427967 0.8931085 0.0000000 1.690147 0.0000000 0.248082 7.409516 0.03599167 0.00000000 0.06456667 0.06456667 1.039479e-05 1.039479e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000165660 E001 0.1779838 0.0400431041 1.000000e+00   10 124801757 124801762 6 + 0.062 0.000 -7.641
ENSG00000165660 E002 0.5339515 0.9003321096 1.000000e+00   10 124801763 124801798 36 + 0.171 0.000 -9.956
ENSG00000165660 E003 0.6648197 0.5327037564 7.022421e-01   10 124801799 124801803 5 + 0.169 0.221 0.478
ENSG00000165660 E004 0.8262353 0.1669581036 1.000000e+00   10 124801804 124801809 6 + 0.209 0.224 0.126
ENSG00000165660 E005 11.0436641 0.0033644439 2.221967e-03 0.018537091 10 124801810 124801818 9 + 1.038 0.572 -1.859
ENSG00000165660 E006 57.6112739 0.0008792278 1.255418e-02 0.068658655 10 124801819 124801901 83 + 1.686 1.537 -0.506
ENSG00000165660 E007 52.1106056 0.0010372467 4.761380e-02 0.174078473 10 124806831 124806834 4 + 1.640 1.520 -0.411
ENSG00000165660 E008 85.0323891 0.0004492175 5.286412e-03 0.036113853 10 124806835 124806921 87 + 1.851 1.718 -0.448
ENSG00000165660 E009 63.2338916 0.0006425249 2.249514e-01 0.459384044 10 124816576 124816612 37 + 1.711 1.651 -0.205
ENSG00000165660 E010 65.2250654 0.0006835043 5.442497e-01 0.732125667 10 124819384 124819450 67 + 1.719 1.695 -0.081
ENSG00000165660 E011 41.2457098 0.0050394925 1.748615e-01 0.396990541 10 124826595 124826598 4 + 1.540 1.441 -0.340
ENSG00000165660 E012 119.8349504 0.0004336772 6.962679e-02 0.224020131 10 124826599 124826785 187 + 1.986 1.919 -0.225
ENSG00000165660 E013 111.0516162 0.0004716238 1.107190e-01 0.300172230 10 124828756 124828875 120 + 1.953 1.893 -0.200
ENSG00000165660 E014 112.6519399 0.0005062446 1.608474e-01 0.378019025 10 124829393 124829477 85 + 1.959 1.908 -0.171
ENSG00000165660 E015 61.8215625 0.0017963148 8.083660e-01 0.901219360 10 124831349 124831352 4 + 1.695 1.689 -0.021
ENSG00000165660 E016 117.2670509 0.0027684720 2.973989e-01 0.537907924 10 124831353 124831463 111 + 1.957 2.013 0.187
ENSG00000165660 E017 183.6391809 0.0003607859 1.172602e-01 0.311230844 10 124834502 124834828 327 + 2.151 2.210 0.197
ENSG00000165660 E018 320.5708712 0.0025574146 1.670186e-01 0.386575594 10 124834829 124835686 858 + 2.392 2.442 0.166
ENSG00000165660 E019 313.0321908 0.0012024782 8.940527e-05 0.001360734 10 124835687 124836667 981 + 2.366 2.477 0.368