ENSG00000165458

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000298229 ENSG00000165458 HEK293_OSMI2_6hA HEK293_TMG_6hB INPPL1 protein_coding protein_coding 53.58138 71.91022 38.18207 4.38722 1.352822 -0.9131243 4.152030 8.069450 0.1717740 1.015838 0.1717740 -5.4740395 0.06510833 0.11130000 0.004666667 -0.10663333 0.01874268 0.01874268 FALSE TRUE
ENST00000538751 ENSG00000165458 HEK293_OSMI2_6hA HEK293_TMG_6hB INPPL1 protein_coding protein_coding 53.58138 71.91022 38.18207 4.38722 1.352822 -0.9131243 4.574904 4.469933 6.1576448 1.453499 0.9474459 0.4612425 0.09166250 0.06006667 0.163233333 0.10316667 0.19025557 0.01874268 FALSE TRUE
ENST00000541752 ENSG00000165458 HEK293_OSMI2_6hA HEK293_TMG_6hB INPPL1 protein_coding protein_coding 53.58138 71.91022 38.18207 4.38722 1.352822 -0.9131243 7.947107 10.346373 0.5463462 1.521518 0.5463462 -4.2183921 0.12128750 0.14406667 0.014833333 -0.12923333 0.10616158 0.01874268 FALSE FALSE
ENST00000545355 ENSG00000165458 HEK293_OSMI2_6hA HEK293_TMG_6hB INPPL1 protein_coding retained_intron 53.58138 71.91022 38.18207 4.38722 1.352822 -0.9131243 7.252936 8.375918 7.4389259 2.786685 0.4362266 -0.1709363 0.14379583 0.11390000 0.195866667 0.08196667 0.42066441 0.01874268 FALSE TRUE
MSTRG.5911.13 ENSG00000165458 HEK293_OSMI2_6hA HEK293_TMG_6hB INPPL1 protein_coding   53.58138 71.91022 38.18207 4.38722 1.352822 -0.9131243 8.239266 13.386936 5.3861990 3.547651 1.0976623 -1.3118876 0.14782083 0.19186667 0.139466667 -0.05240000 0.89217047 0.01874268 FALSE TRUE
MSTRG.5911.4 ENSG00000165458 HEK293_OSMI2_6hA HEK293_TMG_6hB INPPL1 protein_coding   53.58138 71.91022 38.18207 4.38722 1.352822 -0.9131243 5.868982 9.362991 1.8439158 2.211515 0.2862079 -2.3379337 0.10917917 0.13290000 0.048200000 -0.08470000 0.22746561 0.01874268 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000165458 E001 4.4206779 0.2046842765 7.272405e-01 8.525740e-01 11 72223685 72223700 16 + 0.748 0.637 -0.465
ENSG00000165458 E002 7.3314673 0.1547414722 8.095272e-01 9.018863e-01 11 72223701 72223803 103 + 0.829 0.860 0.120
ENSG00000165458 E003 0.0000000       11 72223871 72223890 20 +      
ENSG00000165458 E004 16.7636019 0.0027423367 4.304964e-03 3.086166e-02 11 72223891 72223943 53 + 0.946 1.257 1.121
ENSG00000165458 E005 18.3717019 0.0027489627 4.891213e-03 3.403706e-02 11 72223944 72223960 17 + 0.998 1.291 1.049
ENSG00000165458 E006 7.6163764 0.0419833702 1.532554e-01 3.670120e-01 11 72223961 72224114 154 + 0.691 0.944 0.993
ENSG00000165458 E007 1.5112959 0.1337949469 8.348486e-01 9.164333e-01 11 72224115 72224119 5 + 0.326 0.389 0.371
ENSG00000165458 E008 3.7443544 0.0280475530 7.529371e-01 8.684958e-01 11 72224120 72224146 27 + 0.580 0.638 0.255
ENSG00000165458 E009 12.7126635 0.0110847369 7.082953e-02 2.263716e-01 11 72224147 72224184 38 + 0.888 1.113 0.833
ENSG00000165458 E010 1.4464394 0.4010118039 9.422368e-01 9.733890e-01 11 72224185 72224205 21 + 0.327 0.361 0.205
ENSG00000165458 E011 1.6534980 0.0158660781 8.455177e-01 9.224166e-01 11 72224767 72224779 13 + 0.428 0.395 -0.182
ENSG00000165458 E012 65.8649260 0.0011973324 2.275595e-05 4.267318e-04 11 72224780 72225068 289 + 1.566 1.810 0.826
ENSG00000165458 E013 60.2166121 0.0014748474 6.524558e-02 2.144334e-01 11 72225069 72225166 98 + 1.639 1.744 0.357
ENSG00000165458 E014 15.1561537 0.2026446873 2.735400e-03 2.177741e-02 11 72227881 72228189 309 + 1.516 0.899 -2.201
ENSG00000165458 E015 87.8559223 0.0008667373 5.719286e-01 7.516436e-01 11 72228190 72228253 64 + 1.900 1.876 -0.081
ENSG00000165458 E016 142.9622264 0.0003190161 8.631071e-01 9.320670e-01 11 72228348 72228467 120 + 2.098 2.093 -0.015
ENSG00000165458 E017 113.1270571 0.0004158813 8.962042e-01 9.498987e-01 11 72228468 72228498 31 + 1.988 1.995 0.022
ENSG00000165458 E018 19.5000352 0.1449529576 2.201214e-02 1.026236e-01 11 72228499 72228715 217 + 1.512 1.115 -1.387
ENSG00000165458 E019 182.2608480 0.0003105149 4.654391e-01 6.768934e-01 11 72228727 72228847 121 + 2.182 2.207 0.081
ENSG00000165458 E020 18.4567370 0.2122206211 1.213970e-01 3.180745e-01 11 72228849 72229007 159 + 1.414 1.145 -0.942
ENSG00000165458 E021 20.9297125 0.0395126965 7.047739e-03 4.485172e-02 11 72229008 72229089 82 + 1.495 1.184 -1.084
ENSG00000165458 E022 225.3668446 0.0002997984 9.110839e-03 5.431736e-02 11 72229090 72229230 141 + 2.343 2.274 -0.231
ENSG00000165458 E023 223.5026723 0.0002160690 8.732236e-03 5.263112e-02 11 72229465 72229558 94 + 2.339 2.270 -0.230
ENSG00000165458 E024 206.7854722 0.0002325866 3.506736e-02 1.417544e-01 11 72229663 72229752 90 + 2.298 2.241 -0.191
ENSG00000165458 E025 217.8247187 0.0002934322 9.234807e-03 5.484848e-02 11 72229924 72230019 96 + 2.330 2.260 -0.233
ENSG00000165458 E026 3.5678953 0.0123932107 2.423238e-04 3.135402e-03 11 72230101 72230120 20 + 0.946 0.396 -2.395
ENSG00000165458 E027 271.7986654 0.0002139040 8.195480e-02 2.486567e-01 11 72230121 72230271 151 + 2.405 2.364 -0.137
ENSG00000165458 E028 259.4030483 0.0002091511 6.020305e-03 3.982016e-02 11 72230362 72230468 107 + 2.403 2.336 -0.223
ENSG00000165458 E029 4.4040932 0.0718202676 9.410046e-04 9.429647e-03 11 72230718 72230795 78 + 1.023 0.458 -2.350
ENSG00000165458 E030 287.7258105 0.0001950383 8.756428e-06 1.870259e-04 11 72230796 72230898 103 + 2.471 2.369 -0.343
ENSG00000165458 E031 340.0498401 0.0001898303 1.446745e-02 7.612881e-02 11 72230993 72231141 149 + 2.508 2.455 -0.175
ENSG00000165458 E032 204.1578200 0.0011763205 9.518301e-01 9.778720e-01 11 72231142 72231189 48 + 2.248 2.246 -0.006
ENSG00000165458 E033 12.8803430 0.1379751654 4.467214e-02 1.667844e-01 11 72231190 72231249 60 + 1.354 0.940 -1.487
ENSG00000165458 E034 23.9311501 0.1052948620 1.907498e-03 1.645607e-02 11 72231250 72231497 248 + 1.647 1.151 -1.723
ENSG00000165458 E035 304.8692860 0.0002078095 5.146424e-02 1.832092e-01 11 72231498 72231615 118 + 2.456 2.412 -0.146
ENSG00000165458 E036 243.8883318 0.0001928670 2.996660e-02 1.272477e-01 11 72232240 72232307 68 + 2.366 2.312 -0.181
ENSG00000165458 E037 194.7176304 0.0002403605 2.020479e-02 9.659744e-02 11 72232308 72232336 29 + 2.278 2.213 -0.217
ENSG00000165458 E038 27.7814683 0.2053468926 1.533322e-02 7.932773e-02 11 72232337 72232625 289 + 1.686 1.236 -1.552
ENSG00000165458 E039 334.2863237 0.0004207090 3.750566e-01 6.082265e-01 11 72232626 72232764 139 + 2.478 2.459 -0.064
ENSG00000165458 E040 0.9400874 0.0156029560 1.320796e-01   11 72232871 72232874 4 + 0.001 0.325 9.474
ENSG00000165458 E041 271.0382562 0.0001815894 4.009303e-01 6.290496e-01 11 72232875 72232974 100 + 2.385 2.366 -0.064
ENSG00000165458 E042 294.0948138 0.0001991516 1.831738e-01 4.080240e-01 11 72233075 72233163 89 + 2.428 2.398 -0.101
ENSG00000165458 E043 303.7656909 0.0002188915 1.688056e-01 3.889954e-01 11 72233441 72233522 82 + 2.443 2.411 -0.104
ENSG00000165458 E044 72.8318863 0.1101877970 1.047302e-02 6.015626e-02 11 72233523 72233654 132 + 2.046 1.683 -1.224
ENSG00000165458 E045 223.2889868 0.0015105352 2.899409e-01 5.305290e-01 11 72233655 72233679 25 + 2.311 2.276 -0.117
ENSG00000165458 E046 321.5577830 0.0020556768 4.512736e-01 6.665389e-01 11 72233680 72233744 65 + 2.462 2.437 -0.083
ENSG00000165458 E047 405.2122069 0.0008430018 5.397961e-02 1.890411e-01 11 72234281 72234394 114 + 2.577 2.531 -0.154
ENSG00000165458 E048 336.0424005 0.0008852942 2.986377e-01 5.390868e-01 11 72234527 72234615 89 + 2.482 2.456 -0.088
ENSG00000165458 E049 4.6390155 0.0933257854 3.206613e-01 5.602781e-01 11 72234616 72234646 31 + 0.821 0.654 -0.682
ENSG00000165458 E050 316.2366837 0.0002946432 7.000651e-01 8.356856e-01 11 72235116 72235203 88 + 2.429 2.440 0.035
ENSG00000165458 E051 314.6421447 0.0002980153 5.141464e-02 1.831069e-01 11 72235296 72235451 156 + 2.400 2.449 0.163
ENSG00000165458 E052 190.3309888 0.0069693512 1.962640e-02 9.464151e-02 11 72235675 72235753 79 + 2.124 2.246 0.409
ENSG00000165458 E053 130.0248260 0.0098381106 9.018763e-03 5.391036e-02 11 72235846 72235896 51 + 1.925 2.089 0.549
ENSG00000165458 E054 135.2294295 0.0010559908 2.953537e-04 3.682661e-03 11 72235897 72235986 90 + 1.959 2.105 0.487
ENSG00000165458 E055 153.0713879 0.0052567921 7.680546e-04 8.012368e-03 11 72237124 72237205 82 + 1.994 2.161 0.562
ENSG00000165458 E056 602.0478363 0.0001611436 9.701730e-18 2.131406e-15 11 72237206 72237659 454 + 2.595 2.752 0.522
ENSG00000165458 E057 282.6893152 0.0023344132 2.979329e-04 3.709374e-03 11 72237660 72237796 137 + 2.291 2.418 0.422
ENSG00000165458 E058 250.9479804 0.0015649285 2.301433e-02 1.059898e-01 11 72238042 72238175 134 + 2.282 2.358 0.253
ENSG00000165458 E059 5.5137065 0.0277923819 2.343718e-01 4.701305e-01 11 72238176 72238262 87 + 0.887 0.708 -0.711
ENSG00000165458 E060 797.3822265 0.0020363135 4.152180e-07 1.316288e-05 11 72238263 72239020 758 + 2.736 2.866 0.433
ENSG00000165458 E061 53.7398349 0.0088097881 2.622924e-02 1.160253e-01 11 72239021 72239147 127 + 1.546 1.715 0.575