ENSG00000165283

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000356493 ENSG00000165283 HEK293_OSMI2_6hA HEK293_TMG_6hB STOML2 protein_coding protein_coding 381.3207 435.7795 232.4433 52.76876 6.757067 -0.9066903 244.79326 324.79312 116.30606 51.372874 3.908240 -1.48151518 0.619375 0.73763333 0.50136667 -0.2362667 2.671988e-03 8.934079e-05 FALSE TRUE
ENST00000487490 ENSG00000165283 HEK293_OSMI2_6hA HEK293_TMG_6hB STOML2 protein_coding processed_transcript 381.3207 435.7795 232.4433 52.76876 6.757067 -0.9066903 18.51932 15.37386 19.20451 3.937131 1.391368 0.32077899 0.058775 0.03893333 0.08263333 0.0437000 2.949319e-01 8.934079e-05   FALSE
MSTRG.32608.4 ENSG00000165283 HEK293_OSMI2_6hA HEK293_TMG_6hB STOML2 protein_coding   381.3207 435.7795 232.4433 52.76876 6.757067 -0.9066903 98.89378 76.40676 81.29332 7.795731 7.623639 0.08942516 0.266950 0.17646667 0.34883333 0.1723667 8.934079e-05 8.934079e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000165283 E001 0.3447487 5.585749e-01 7.267513e-01   9 35099776 35099777 2 - 0.001 0.152 8.447
ENSG00000165283 E002 1.3567022 2.003245e-02 3.951050e-02   9 35099778 35099890 113 - 0.000 0.423 13.444
ENSG00000165283 E003 17.7233648 5.731238e-03 9.861097e-08 3.663621e-06 9 35099891 35099893 3 - 0.704 1.344 2.376
ENSG00000165283 E004 20.0145155 8.885493e-03 7.426034e-06 1.619509e-04 9 35099894 35099894 1 - 0.880 1.381 1.805
ENSG00000165283 E005 21.7850266 7.053773e-03 2.082012e-04 2.764021e-03 9 35099895 35099895 1 - 1.026 1.399 1.322
ENSG00000165283 E006 531.1562134 2.203897e-03 2.578218e-01 4.966037e-01 9 35099896 35100005 110 - 2.654 2.690 0.118
ENSG00000165283 E007 696.0017879 2.812177e-03 9.803613e-01 9.919492e-01 9 35100006 35100024 19 - 2.795 2.798 0.009
ENSG00000165283 E008 2546.0028089 4.741540e-05 1.625322e-01 3.805295e-01 9 35100025 35100172 148 - 3.367 3.355 -0.040
ENSG00000165283 E009 2824.1595206 4.069463e-05 8.716072e-01 9.368347e-01 9 35100598 35100726 129 - 3.403 3.403 0.001
ENSG00000165283 E010 63.1513127 1.383092e-01 4.754071e-02 1.738849e-01 9 35100727 35100931 205 - 1.962 1.649 -1.058
ENSG00000165283 E011 1957.9771978 5.677187e-05 8.461818e-02 2.539889e-01 9 35100932 35101011 80 - 3.234 3.249 0.049
ENSG00000165283 E012 3332.1882326 5.419847e-05 1.819062e-02 8.965077e-02 9 35101135 35101279 145 - 3.464 3.480 0.053
ENSG00000165283 E013 1798.7473307 5.993681e-04 7.055634e-02 2.258385e-01 9 35101426 35101449 24 - 3.228 3.202 -0.089
ENSG00000165283 E014 2909.9608840 5.325152e-05 1.157861e-02 6.473250e-02 9 35101450 35101560 111 - 3.431 3.411 -0.067
ENSG00000165283 E015 2516.4602055 6.063066e-05 6.775076e-02 2.200331e-01 9 35101710 35101780 71 - 3.364 3.349 -0.053
ENSG00000165283 E016 1984.2618607 3.220335e-04 1.654874e-01 3.845293e-01 9 35101781 35101811 31 - 3.262 3.246 -0.054
ENSG00000165283 E017 2177.0865058 1.501281e-04 2.823481e-02 1.219678e-01 9 35101904 35101962 59 - 3.306 3.284 -0.073
ENSG00000165283 E018 2353.4276893 2.968640e-04 9.259901e-01 9.651181e-01 9 35102095 35102194 100 - 3.324 3.326 0.004
ENSG00000165283 E019 102.3258961 1.006278e-01 1.235706e-02 6.786358e-02 9 35102195 35102364 170 - 2.199 1.830 -1.240
ENSG00000165283 E020 1909.0746690 4.995028e-04 8.340402e-05 1.285059e-03 9 35102686 35102823 138 - 3.195 3.250 0.183
ENSG00000165283 E021 37.0055815 3.167715e-02 6.991400e-02 2.246335e-01 9 35102910 35102946 37 - 1.661 1.473 -0.643
ENSG00000165283 E022 26.9636410 1.445466e-02 5.658270e-02 1.950402e-01 9 35102947 35102953 7 - 1.518 1.344 -0.599
ENSG00000165283 E023 53.2243541 2.894601e-02 3.322334e-01 5.710472e-01 9 35102954 35103049 96 - 1.754 1.661 -0.314
ENSG00000165283 E024 840.3507051 1.111284e-03 3.883788e-08 1.591210e-06 9 35103050 35103160 111 - 2.791 2.910 0.395
ENSG00000165283 E025 25.8539156 4.363769e-02 7.218067e-01 8.491727e-01 9 35103161 35103258 98 - 1.354 1.408 0.184