ENSG00000165219

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000297933 ENSG00000165219 HEK293_OSMI2_6hA HEK293_TMG_6hB GAPVD1 protein_coding protein_coding 17.10861 7.534821 28.11425 1.455762 0.4487444 1.898256 0.6834121 0.7974532 1.2130615 0.2593376 0.14727545 0.5990465 0.04303333 0.09870000 0.043100000 -0.055600000 1.241364e-01 4.110959e-21 FALSE TRUE
ENST00000312123 ENSG00000165219 HEK293_OSMI2_6hA HEK293_TMG_6hB GAPVD1 protein_coding protein_coding 17.10861 7.534821 28.11425 1.455762 0.4487444 1.898256 0.6469343 0.4580698 0.6649129 0.2299466 0.66491290 0.5279776 0.08966667 0.07243333 0.024433333 -0.048000000 6.322079e-01 4.110959e-21 FALSE TRUE
ENST00000394105 ENSG00000165219 HEK293_OSMI2_6hA HEK293_TMG_6hB GAPVD1 protein_coding protein_coding 17.10861 7.534821 28.11425 1.455762 0.4487444 1.898256 0.9369928 0.4615750 1.3389208 0.1697116 0.07648649 1.5162466 0.05811250 0.05636667 0.047600000 -0.008766667 9.118954e-01 4.110959e-21 FALSE TRUE
ENST00000461379 ENSG00000165219 HEK293_OSMI2_6hA HEK293_TMG_6hB GAPVD1 protein_coding protein_coding 17.10861 7.534821 28.11425 1.455762 0.4487444 1.898256 2.2041126 0.0000000 4.7123560 0.0000000 0.16197925 8.8833630 0.08075000 0.00000000 0.167566667 0.167566667 4.677961e-19 4.110959e-21 FALSE FALSE
ENST00000467750 ENSG00000165219 HEK293_OSMI2_6hA HEK293_TMG_6hB GAPVD1 protein_coding protein_coding 17.10861 7.534821 28.11425 1.455762 0.4487444 1.898256 3.4491180 0.0000000 7.7418510 0.0000000 0.53705102 9.5983970 0.12604167 0.00000000 0.275666667 0.275666667 4.110959e-21 4.110959e-21 FALSE TRUE
ENST00000470056 ENSG00000165219 HEK293_OSMI2_6hA HEK293_TMG_6hB GAPVD1 protein_coding protein_coding 17.10861 7.534821 28.11425 1.455762 0.4487444 1.898256 0.3608015 0.7611810 0.1570691 0.3817142 0.15706909 -2.2066247 0.04601667 0.08480000 0.005766667 -0.079033333 4.660350e-01 4.110959e-21 FALSE TRUE
MSTRG.33386.13 ENSG00000165219 HEK293_OSMI2_6hA HEK293_TMG_6hB GAPVD1 protein_coding   17.10861 7.534821 28.11425 1.455762 0.4487444 1.898256 0.2682461 0.4676012 0.2112228 0.4104804 0.02543320 -1.1103061 0.01490417 0.05816667 0.007500000 -0.050666667 7.565251e-01 4.110959e-21 FALSE TRUE
MSTRG.33386.14 ENSG00000165219 HEK293_OSMI2_6hA HEK293_TMG_6hB GAPVD1 protein_coding   17.10861 7.534821 28.11425 1.455762 0.4487444 1.898256 0.6577834 0.0000000 1.6232849 0.0000000 0.81759469 7.3516327 0.02410833 0.00000000 0.056866667 0.056866667 4.635226e-01 4.110959e-21 FALSE TRUE
MSTRG.33386.2 ENSG00000165219 HEK293_OSMI2_6hA HEK293_TMG_6hB GAPVD1 protein_coding   17.10861 7.534821 28.11425 1.455762 0.4487444 1.898256 0.3985979 1.1651404 0.0000000 0.5826322 0.00000000 -6.8766893 0.05570000 0.13010000 0.000000000 -0.130100000 1.163656e-01 4.110959e-21 FALSE TRUE
MSTRG.33386.4 ENSG00000165219 HEK293_OSMI2_6hA HEK293_TMG_6hB GAPVD1 protein_coding   17.10861 7.534821 28.11425 1.455762 0.4487444 1.898256 3.9165671 2.3383581 5.6629940 0.5589184 0.17891910 1.2724579 0.22947083 0.31123333 0.201733333 -0.109500000 2.799147e-01 4.110959e-21 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000165219 E001 0.4632531 0.0257753189 2.811485e-01   9 125261794 125261809 16 + 0.220 0.000 -9.571
ENSG00000165219 E002 0.9866059 0.0457437436 4.046431e-01   9 125261810 125261822 13 + 0.322 0.169 -1.209
ENSG00000165219 E003 1.6300557 0.0117149137 9.703670e-02 2.765779e-01 9 125261823 125261825 3 + 0.474 0.168 -2.063
ENSG00000165219 E004 2.2735056 0.0090043693 2.327967e-02 1.068258e-01 9 125261826 125261828 3 + 0.586 0.168 -2.594
ENSG00000165219 E005 2.7555397 0.0078725402 7.886595e-03 4.879835e-02 9 125261829 125261830 2 + 0.655 0.168 -2.893
ENSG00000165219 E006 3.0783711 0.0075760269 3.832961e-03 2.820628e-02 9 125261831 125261831 1 + 0.695 0.168 -3.064
ENSG00000165219 E007 10.9509558 0.0212994631 3.232157e-03 2.479373e-02 9 125261832 125261842 11 + 1.141 0.756 -1.449
ENSG00000165219 E008 25.3410825 0.0148750787 3.182670e-01 5.581736e-01 9 125261843 125261867 25 + 1.415 1.337 -0.269
ENSG00000165219 E009 37.6225081 0.0019209368 1.219862e-01 3.190225e-01 9 125261868 125261910 43 + 1.587 1.507 -0.271
ENSG00000165219 E010 45.9999582 0.0009558624 3.945264e-01 6.239769e-01 9 125261911 125261954 44 + 1.657 1.629 -0.095
ENSG00000165219 E011 32.3894263 0.0175467732 9.846332e-01 9.941482e-01 9 125261955 125261959 5 + 1.491 1.515 0.080
ENSG00000165219 E012 4.6359748 0.0056066458 8.511928e-01 9.256929e-01 9 125263551 125263700 150 + 0.714 0.758 0.178
ENSG00000165219 E013 15.2935179 0.0023738875 1.056727e-01 2.918183e-01 9 125268936 125268984 49 + 1.226 1.092 -0.481
ENSG00000165219 E014 0.0000000       9 125268985 125269054 70 +      
ENSG00000165219 E015 5.0485958 0.0052497327 6.708224e-01 8.168693e-01 9 125287762 125287883 122 + 0.766 0.721 -0.183
ENSG00000165219 E016 16.0879835 0.0024292835 5.587503e-01 7.423773e-01 9 125295458 125295574 117 + 1.185 1.256 0.250
ENSG00000165219 E017 0.3393995 0.0274424043 5.038048e-01   9 125298886 125298889 4 + 0.158 0.000 -11.452
ENSG00000165219 E018 40.8653602 0.0079689318 5.538089e-02 1.921966e-01 9 125298890 125298921 32 + 1.631 1.511 -0.409
ENSG00000165219 E019 114.0708642 0.0003895408 8.336758e-11 6.006675e-09 9 125298922 125299106 185 + 2.094 1.866 -0.767
ENSG00000165219 E020 137.1332302 0.0015158607 3.447446e-10 2.185351e-08 9 125301983 125302209 227 + 2.171 1.945 -0.759
ENSG00000165219 E021 79.0013580 0.0041906740 6.189242e-04 6.743283e-03 9 125302210 125302306 97 + 1.922 1.753 -0.569
ENSG00000165219 E022 232.2539450 0.0001987781 2.858512e-10 1.838792e-08 9 125302307 125302826 520 + 2.380 2.236 -0.480
ENSG00000165219 E023 66.3423663 0.0022777954 1.340707e-01 3.381998e-01 9 125305063 125305149 87 + 1.821 1.761 -0.201
ENSG00000165219 E024 86.9548600 0.0004571004 5.103656e-03 3.517525e-02 9 125307413 125307547 135 + 1.946 1.848 -0.328
ENSG00000165219 E025 128.0948825 0.0003997333 3.323243e-04 4.060166e-03 9 125307691 125307880 190 + 2.115 2.010 -0.353
ENSG00000165219 E026 0.6494192 0.0216861471 7.663098e-01   9 125307881 125309300 1420 + 0.220 0.169 -0.475
ENSG00000165219 E027 0.0000000       9 125309929 125310009 81 +      
ENSG00000165219 E028 124.2209720 0.0003279243 1.205382e-03 1.147301e-02 9 125312452 125312612 161 + 2.097 2.004 -0.313
ENSG00000165219 E029 76.1667727 0.0006002226 5.376259e-03 3.657319e-02 9 125321433 125321499 67 + 1.889 1.783 -0.359
ENSG00000165219 E030 62.7712379 0.0005861622 1.228891e-01 3.202961e-01 9 125321500 125321562 63 + 1.792 1.736 -0.188
ENSG00000165219 E031 119.7002106 0.0022147963 1.319132e-02 7.121391e-02 9 125323798 125323923 126 + 2.080 1.993 -0.292
ENSG00000165219 E032 161.8281273 0.0019605875 3.749255e-02 1.482858e-01 9 125326416 125326589 174 + 2.203 2.145 -0.194
ENSG00000165219 E033 113.2317193 0.0004147357 1.438432e-01 3.531673e-01 9 125330078 125330218 141 + 2.041 2.007 -0.112
ENSG00000165219 E034 97.7683822 0.0003902036 6.490493e-01 8.028867e-01 9 125331926 125332017 92 + 1.955 1.991 0.123
ENSG00000165219 E035 72.6909279 0.0005491026 1.976604e-02 9.509385e-02 9 125332018 125332060 43 + 1.793 1.913 0.404
ENSG00000165219 E036 117.0384826 0.0008571691 5.536832e-01 7.388490e-01 9 125332510 125332629 120 + 2.027 2.068 0.137
ENSG00000165219 E037 7.8267929 0.0035707011 5.409145e-01 7.296935e-01 9 125335172 125335252 81 + 0.939 0.882 -0.216
ENSG00000165219 E038 2.8017596 0.1864963610 2.852004e-01 5.257777e-01 9 125336709 125337017 309 + 0.470 0.691 1.007
ENSG00000165219 E039 99.8081128 0.0005566158 4.931137e-02 1.779499e-01 9 125337018 125337095 78 + 1.989 1.931 -0.196
ENSG00000165219 E040 219.3532237 0.0002609610 7.470689e-02 2.342235e-01 9 125337221 125337591 371 + 2.321 2.293 -0.092
ENSG00000165219 E041 97.6909029 0.0005389972 5.211833e-01 7.156870e-01 9 125341177 125341234 58 + 1.968 1.963 -0.019
ENSG00000165219 E042 75.7061352 0.0004848535 6.756210e-01 8.199469e-01 9 125341235 125341264 30 + 1.856 1.857 0.003
ENSG00000165219 E043 1.2846868 0.0130835385 2.498392e-02   9 125341265 125341751 487 + 0.441 0.000 -13.615
ENSG00000165219 E044 2.0751251 0.0107300653 6.626539e-01 8.115463e-01 9 125341752 125342106 355 + 0.441 0.527 0.428
ENSG00000165219 E045 97.5259757 0.0004173777 5.258181e-02 1.856852e-01 9 125342219 125342299 81 + 1.982 1.926 -0.190
ENSG00000165219 E046 3.8116373 0.3297114206 7.797038e-01 8.845251e-01 9 125345890 125346818 929 + 0.642 0.684 0.178
ENSG00000165219 E047 131.9692004 0.0004122481 5.996695e-01 7.699926e-01 9 125346819 125346941 123 + 2.092 2.094 0.004
ENSG00000165219 E048 2.7727256 0.2486658357 1.982497e-01 4.274164e-01 9 125346942 125346995 54 + 0.646 0.292 -1.838
ENSG00000165219 E049 127.4310117 0.0003390526 8.216085e-01 9.089102e-01 9 125349390 125349519 130 + 2.069 2.095 0.089
ENSG00000165219 E050 114.2886783 0.0003931412 6.467121e-01 8.012884e-01 9 125350295 125350404 110 + 2.020 2.055 0.120
ENSG00000165219 E051 142.5725560 0.0004333128 3.150517e-01 5.551776e-01 9 125350713 125350872 160 + 2.111 2.162 0.173
ENSG00000165219 E052 97.5377834 0.0009314108 2.665674e-01 5.060621e-01 9 125354654 125354696 43 + 1.944 2.007 0.214
ENSG00000165219 E053 161.8429757 0.0009211771 1.570124e-01 3.722819e-01 9 125354697 125354841 145 + 2.160 2.224 0.213
ENSG00000165219 E054 181.0939734 0.0002735828 1.355759e-04 1.927729e-03 9 125355644 125355857 214 + 2.186 2.311 0.415
ENSG00000165219 E055 112.3577408 0.0013480241 4.060604e-02 1.563222e-01 9 125359420 125359492 73 + 1.987 2.084 0.325
ENSG00000165219 E056 0.4764247 0.0217681645 1.000000e+00   9 125359493 125359847 355 + 0.158 0.168 0.108
ENSG00000165219 E057 176.5344201 0.0010457683 8.004302e-07 2.340821e-05 9 125360528 125360725 198 + 2.157 2.328 0.571
ENSG00000165219 E058 748.1351470 0.0016605541 4.356991e-21 1.453668e-18 9 125362606 125367207 4602 + 2.761 2.982 0.734