ENSG00000165175

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000336949 ENSG00000165175 HEK293_OSMI2_6hA HEK293_TMG_6hB MID1IP1 protein_coding protein_coding 36.00762 49.11321 23.98494 6.352072 0.7479331 -1.033674 2.579300 2.369329 3.818919 0.2260466 0.2302774 0.6863824 0.08561250 0.05156667 0.1598333 0.10826667 4.755336e-03 2.022605e-22 FALSE TRUE
ENST00000378474 ENSG00000165175 HEK293_OSMI2_6hA HEK293_TMG_6hB MID1IP1 protein_coding protein_coding 36.00762 49.11321 23.98494 6.352072 0.7479331 -1.033674 21.553679 29.569590 13.198915 4.4604207 0.1408115 -1.1630901 0.57813750 0.59816667 0.5510667 -0.04710000 6.729687e-01 2.022605e-22 FALSE TRUE
ENST00000614558 ENSG00000165175 HEK293_OSMI2_6hA HEK293_TMG_6hB MID1IP1 protein_coding protein_coding 36.00762 49.11321 23.98494 6.352072 0.7479331 -1.033674 6.815397 9.380469 5.711738 1.0871269 0.2172141 -0.7147438 0.19390417 0.19213333 0.2383667 0.04623333 4.151511e-01 2.022605e-22 FALSE TRUE
MSTRG.34073.2 ENSG00000165175 HEK293_OSMI2_6hA HEK293_TMG_6hB MID1IP1 protein_coding   36.00762 49.11321 23.98494 6.352072 0.7479331 -1.033674 3.010860 5.477853 0.000000 0.7776809 0.0000000 -9.1000980 0.07441667 0.11203333 0.0000000 -0.11203333 2.022605e-22 2.022605e-22 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000165175 E001 0.6011358 3.8359210082 4.513238e-01   X 38801309 38801439 131 + 0.338 0.120 -1.882
ENSG00000165175 E002 1.4656530 0.9326145258 7.191322e-01 8.476336e-01 X 38801440 38801453 14 + 0.328 0.361 0.198
ENSG00000165175 E003 1.6082876 0.2656638687 8.298655e-01 9.137075e-01 X 38801454 38801454 1 + 0.428 0.361 -0.370
ENSG00000165175 E004 2.0541648 0.0146355994 7.255340e-01 8.514609e-01 X 38801455 38801458 4 + 0.511 0.426 -0.428
ENSG00000165175 E005 26.9266399 0.0077385889 8.344343e-03 5.090385e-02 X 38801459 38801487 29 + 1.531 1.321 -0.724
ENSG00000165175 E006 71.4824335 0.0351359658 1.034562e-04 1.538732e-03 X 38801488 38802534 1047 + 2.058 1.664 -1.329
ENSG00000165175 E007 255.0414437 0.0015448779 6.226349e-10 3.766930e-08 X 38802535 38803409 875 + 2.471 2.298 -0.579
ENSG00000165175 E008 365.4031430 0.0012366905 4.354523e-01 6.553337e-01 X 38803410 38804309 900 + 2.510 2.500 -0.034
ENSG00000165175 E009 290.3797658 0.0003848294 2.680451e-01 5.077086e-01 X 38804310 38804413 104 + 2.373 2.409 0.118
ENSG00000165175 E010 1565.7453708 0.0017531605 5.125026e-06 1.176304e-04 X 38804683 38806103 1421 + 3.070 3.149 0.260
ENSG00000165175 E011 201.7648657 0.0005963168 2.153389e-01 4.479142e-01 X 38806104 38806537 434 + 2.210 2.257 0.155
ENSG00000165175 E012 0.0000000       X 38820466 38820520 55 +