ENSG00000165152

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000374848 ENSG00000165152 HEK293_OSMI2_6hA HEK293_TMG_6hB PGAP4 protein_coding protein_coding 17.9856 24.19867 12.26889 1.141948 0.3815515 -0.9793438 6.681644 5.860260 6.602197 0.3648537 0.1558676 0.1717054 0.3895458 0.2418667 0.5393333 0.29746667 4.243063e-10 8.25534e-14 FALSE TRUE
MSTRG.33169.1 ENSG00000165152 HEK293_OSMI2_6hA HEK293_TMG_6hB PGAP4 protein_coding   17.9856 24.19867 12.26889 1.141948 0.3815515 -0.9793438 3.284699 2.576178 3.759355 1.0507750 0.3015140 0.5434962 0.1921583 0.1099667 0.3085333 0.19856667 1.413972e-01 8.25534e-14 TRUE TRUE
MSTRG.33169.6 ENSG00000165152 HEK293_OSMI2_6hA HEK293_TMG_6hB PGAP4 protein_coding   17.9856 24.19867 12.26889 1.141948 0.3815515 -0.9793438 6.144979 12.700441 0.000000 2.7983958 0.0000000 -10.3117984 0.3136917 0.5168667 0.0000000 -0.51686667 8.255340e-14 8.25534e-14 TRUE TRUE
MSTRG.33169.7 ENSG00000165152 HEK293_OSMI2_6hA HEK293_TMG_6hB PGAP4 protein_coding   17.9856 24.19867 12.26889 1.141948 0.3815515 -0.9793438 1.603066 2.794185 1.730059 1.0029913 0.8740368 -0.6884447 0.0883500 0.1197000 0.1367667 0.01706667 9.892459e-01 8.25534e-14 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000165152 E001 3.5985627 0.0072123403 2.832882e-02 1.222650e-01 9 101472119 101472140 22 - 0.827 0.527 -1.276
ENSG00000165152 E002 9.2794685 0.0035008271 1.910884e-02 9.283442e-02 9 101472141 101472361 221 - 1.125 0.896 -0.845
ENSG00000165152 E003 0.9475002 0.0153787590 6.427948e-04   9 101473170 101473170 1 - 0.561 0.000 -13.794
ENSG00000165152 E004 224.2620028 0.0011866872 7.420301e-30 5.833971e-27 9 101473171 101474829 1659 - 2.487 2.220 -0.891
ENSG00000165152 E005 24.6945730 0.0957148268 2.152539e-01 4.478162e-01 9 101474830 101474926 97 - 1.520 1.307 -0.735
ENSG00000165152 E006 21.0682005 0.4960880767 9.979067e-01 1.000000e+00 9 101474927 101475021 95 - 1.410 1.270 -0.486
ENSG00000165152 E007 112.6836701 0.0004983567 8.863105e-04 8.983342e-03 9 101475022 101475488 467 - 2.085 1.997 -0.295
ENSG00000165152 E008 240.1728737 0.0022053340 4.715308e-03 3.308684e-02 9 101475489 101475796 308 - 2.280 2.393 0.375
ENSG00000165152 E009 811.0432902 0.0022411787 2.289796e-09 1.247146e-07 9 101475797 101477169 1373 - 2.807 2.923 0.388
ENSG00000165152 E010 0.3032425 0.0244411696 4.558579e-01   9 101480671 101480725 55 - 0.000 0.168 10.089
ENSG00000165152 E011 80.2567001 0.0006359704 6.059010e-05 9.814568e-04 9 101486949 101487205 257 - 1.745 1.946 0.677
ENSG00000165152 E012 0.0000000       9 101489114 101489200 87 -      
ENSG00000165152 E013 0.0000000       9 101531235 101531347 113 -      
ENSG00000165152 E014 0.0000000       9 101531348 101531559 212 -      
ENSG00000165152 E015 0.1614157 0.0330890498 2.492034e-01   9 101532677 101533448 772 - 0.158 0.000 -10.888
ENSG00000165152 E016 0.0000000       9 101533453 101533537 85 -