ENSG00000165119

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000351839 ENSG00000165119 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPK protein_coding protein_coding 611.2141 408.1148 787.9859 112.2336 33.44297 0.9491776 72.74896 14.25536 98.16014 8.500762 8.713392 2.7827684 0.10880417 0.02686667 0.12423333 0.09736667 0.578159630 0.000104287 FALSE TRUE
ENST00000360384 ENSG00000165119 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPK protein_coding protein_coding 611.2141 408.1148 787.9859 112.2336 33.44297 0.9491776 81.52137 68.61300 94.26284 19.305749 8.068367 0.4581501 0.13423750 0.16706667 0.11960000 -0.04746667 0.096454433 0.000104287 FALSE TRUE
ENST00000376281 ENSG00000165119 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPK protein_coding protein_coding 611.2141 408.1148 787.9859 112.2336 33.44297 0.9491776 40.31980 20.78714 46.63975 7.463977 0.233316 1.1654843 0.06291667 0.04713333 0.05936667 0.01223333 0.725805631 0.000104287 FALSE TRUE
MSTRG.32917.13 ENSG00000165119 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPK protein_coding   611.2141 408.1148 787.9859 112.2336 33.44297 0.9491776 81.66799 47.98759 149.03198 18.526671 7.162842 1.6346850 0.11522083 0.10616667 0.18913333 0.08296667 0.233395298 0.000104287 FALSE TRUE
MSTRG.32917.14 ENSG00000165119 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPK protein_coding   611.2141 408.1148 787.9859 112.2336 33.44297 0.9491776 90.60344 70.48196 143.96853 16.578222 9.243609 1.0303230 0.13794583 0.17843333 0.18263333 0.00420000 0.981801404 0.000104287 FALSE TRUE
MSTRG.32917.3 ENSG00000165119 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPK protein_coding   611.2141 408.1148 787.9859 112.2336 33.44297 0.9491776 25.69519 35.62112 27.35003 6.256990 4.323743 -0.3810679 0.04697500 0.09516667 0.03500000 -0.06016667 0.029683120 0.000104287 FALSE TRUE
MSTRG.32917.5 ENSG00000165119 HEK293_OSMI2_6hA HEK293_TMG_6hB HNRNPK protein_coding   611.2141 408.1148 787.9859 112.2336 33.44297 0.9491776 157.73387 124.89728 161.33993 34.972618 9.923719 0.3693354 0.28487083 0.30603333 0.20460000 -0.10143333 0.000104287 0.000104287 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000165119 E001 91.84447 9.669842e-03 3.757146e-01 6.087797e-01 9 83968083 83968196 114 - 1.966 1.944 -0.074
ENSG00000165119 E002 2019.61961 3.124562e-03 8.247983e-08 3.126556e-06 9 83968197 83968908 712 - 3.341 3.216 -0.415
ENSG00000165119 E003 2838.31123 1.938663e-03 2.136467e-01 4.459290e-01 9 83968909 83969197 289 - 3.422 3.474 0.171
ENSG00000165119 E004 3327.85054 2.544686e-03 3.876781e-04 4.611378e-03 9 83969198 83969380 183 - 3.462 3.579 0.389
ENSG00000165119 E005 1238.94866 5.784248e-03 3.584211e-01 5.945292e-01 9 83969381 83969415 35 - 3.052 3.128 0.252
ENSG00000165119 E006 1096.03283 4.812624e-03 3.971888e-01 6.260724e-01 9 83969416 83969440 25 - 3.002 3.070 0.229
ENSG00000165119 E007 34.78053 1.143539e-01 2.909317e-02 1.246327e-01 9 83969496 83969747 252 - 1.659 1.269 -1.345
ENSG00000165119 E008 48.21813 1.051846e-01 2.123050e-03 1.789146e-02 9 83969748 83970161 414 - 1.827 1.288 -1.842
ENSG00000165119 E009 4896.22674 1.714066e-03 9.535461e-01 9.786839e-01 9 83970162 83970312 151 - 3.671 3.695 0.080
ENSG00000165119 E010 3002.78330 2.001531e-03 1.034674e-01 2.879950e-01 9 83970313 83970331 19 - 3.474 3.459 -0.049
ENSG00000165119 E011 45.37744 1.160174e-01 6.730524e-03 4.336930e-02 9 83970332 83970736 405 - 1.796 1.290 -1.734
ENSG00000165119 E012 4086.86890 2.430722e-03 1.794733e-01 4.032908e-01 9 83970737 83970819 83 - 3.607 3.594 -0.044
ENSG00000165119 E013 2472.54155 2.364288e-03 2.018031e-01 4.318746e-01 9 83970897 83970912 16 - 3.390 3.374 -0.053
ENSG00000165119 E014 430.52240 3.608358e-03 6.760358e-02 2.197042e-01 9 83970913 83971146 234 - 2.644 2.597 -0.156
ENSG00000165119 E015 3555.19999 2.191025e-03 5.781123e-01 7.559153e-01 9 83971273 83971356 84 - 3.530 3.559 0.096
ENSG00000165119 E016 3027.63786 2.755571e-03 7.486257e-01 8.658929e-01 9 83971672 83971726 55 - 3.461 3.487 0.088
ENSG00000165119 E017 6296.97863 1.841671e-03 4.851830e-01 6.907099e-01 9 83971882 83972189 308 - 3.775 3.811 0.117
ENSG00000165119 E018 4254.49193 1.326343e-03 1.490634e-01 3.609153e-01 9 83972844 83972972 129 - 3.620 3.618 -0.007
ENSG00000165119 E019 2233.20772 1.569160e-03 4.215564e-03 3.035145e-02 9 83973286 83973291 6 - 3.353 3.318 -0.116
ENSG00000165119 E020 3957.23991 1.632651e-04 9.542290e-03 5.615817e-02 9 83973292 83973399 108 - 3.589 3.587 -0.006
ENSG00000165119 E021 2599.89045 1.649097e-03 4.736074e-01 6.825135e-01 9 83973902 83973973 72 - 3.392 3.426 0.114
ENSG00000165119 E022 2755.33817 4.516810e-02 3.703801e-01 6.042815e-01 9 83974517 83974589 73 - 3.397 3.478 0.270
ENSG00000165119 E023 2186.21605 2.198258e+00 5.957324e-01 7.675778e-01 9 83975462 83975505 44 - 3.257 3.423 0.551
ENSG00000165119 E024 42.70428 1.051482e+00 8.792061e-01 9.409110e-01 9 83975506 83975770 265 - 1.739 1.392 -1.188
ENSG00000165119 E025 68.26145 1.029315e-01 9.877304e-04 9.819655e-03 9 83976508 83976994 487 - 1.980 1.412 -1.929
ENSG00000165119 E026 2816.35865 3.759289e-02 3.982114e-01 6.268278e-01 9 83976995 83977051 57 - 3.412 3.480 0.225
ENSG00000165119 E027 3915.39958 2.659221e-03 9.876516e-01 9.956722e-01 9 83977689 83977786 98 - 3.578 3.592 0.046
ENSG00000165119 E028 3645.07450 8.837259e-05 8.325763e-10 4.936823e-08 9 83978195 83978279 85 - 3.564 3.536 -0.094
ENSG00000165119 E029 2608.87862 1.000672e-03 2.669508e-02 1.173463e-01 9 83978373 83978452 80 - 3.414 3.397 -0.057
ENSG00000165119 E030 33.80707 1.148859e-03 5.495087e-03 3.719082e-02 9 83979601 83979659 59 - 1.589 1.427 -0.555
ENSG00000165119 E031 163.78281 1.777519e-03 2.439273e-04 3.152786e-03 9 83980119 83980152 34 - 2.144 2.292 0.495
ENSG00000165119 E032 731.16375 2.514284e-03 1.895861e-03 1.637438e-02 9 83980153 83980502 350 - 2.808 2.918 0.367
ENSG00000165119 E033 789.19043 2.962995e-03 1.562757e-03 1.405827e-02 9 83980503 83980696 194 - 2.916 2.842 -0.247