ENSG00000165115

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000297814 ENSG00000165115 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF27 protein_coding protein_coding 6.62563 8.627549 4.43879 1.565226 0.3084422 -0.9572091 0.3173968 0.04194758 0.5666368 0.007135344 0.06175707 3.472534 0.06550833 0.0056000 0.1286000 0.12300000 1.765126e-08 1.765126e-08 FALSE TRUE
ENST00000376347 ENSG00000165115 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF27 protein_coding protein_coding 6.62563 8.627549 4.43879 1.565226 0.3084422 -0.9572091 0.3057555 0.16131074 0.4958307 0.069303083 0.03975153 1.562039 0.06012083 0.0181000 0.1117333 0.09363333 6.082625e-04 1.765126e-08 FALSE TRUE
MSTRG.32916.10 ENSG00000165115 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF27 protein_coding   6.62563 8.627549 4.43879 1.565226 0.3084422 -0.9572091 3.9620762 6.04149028 1.9167182 1.345616705 0.33398590 -1.651145 0.55231250 0.6868667 0.4275333 -0.25933333 3.940267e-02 1.765126e-08 FALSE FALSE
MSTRG.32916.11 ENSG00000165115 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF27 protein_coding   6.62563 8.627549 4.43879 1.565226 0.3084422 -0.9572091 1.4310421 2.17680579 0.5237260 0.175491826 0.16437223 -2.034654 0.20093333 0.2640333 0.1225000 -0.14153333 3.386753e-01 1.765126e-08 FALSE FALSE
MSTRG.32916.2 ENSG00000165115 HEK293_OSMI2_6hA HEK293_TMG_6hB KIF27 protein_coding   6.62563 8.627549 4.43879 1.565226 0.3084422 -0.9572091 0.2412859 0.17112790 0.4217848 0.028356826 0.05737420 1.253304 0.04602083 0.0204000 0.0973000 0.07690000 8.724060e-03 1.765126e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000165115 E001 12.7116239 0.002606288 3.904693e-10 2.442382e-08 9 83834099 83835776 1678 - 1.362 0.709 -2.421
ENSG00000165115 E002 10.4162667 0.014823175 1.001225e-06 2.844755e-05 9 83835777 83836697 921 - 1.274 0.679 -2.239
ENSG00000165115 E003 6.8557796 0.078393703 1.457921e-02 7.652711e-02 9 83836698 83837246 549 - 1.080 0.619 -1.801
ENSG00000165115 E004 5.4707722 0.382151670 2.998587e-01 5.402961e-01 9 83837247 83837485 239 - 0.982 0.555 -1.731
ENSG00000165115 E005 5.5978297 0.012573064 4.898959e-04 5.581724e-03 9 83842237 83842401 165 - 1.009 0.507 -2.058
ENSG00000165115 E006 7.6098026 0.012802227 8.160602e-09 3.912263e-07 9 83850099 83850297 199 - 1.181 0.355 -3.486
ENSG00000165115 E007 5.3079463 0.175582196 1.051998e-02 6.034366e-02 9 83853629 83853835 207 - 1.011 0.413 -2.540
ENSG00000165115 E008 3.0789888 0.256204304 2.067166e-02 9.824797e-02 9 83859156 83859371 216 - 0.830 0.215 -3.168
ENSG00000165115 E009 0.6675801 0.655810926 9.656507e-01   9 83867684 83867760 77 - 0.221 0.217 -0.030
ENSG00000165115 E010 2.0192139 0.200091217 8.011469e-02 2.450393e-01 9 83867761 83867860 100 - 0.656 0.216 -2.451
ENSG00000165115 E011 3.6986683 0.175075320 5.102659e-03 3.517123e-02 9 83870519 83870632 114 - 0.905 0.216 -3.450
ENSG00000165115 E012 1.2625092 0.014006095 2.670820e-02   9 83880118 83880296 179 - 0.519 0.119 -2.862
ENSG00000165115 E013 6.5967656 0.005176537 1.591423e-05 3.140736e-04 9 83880297 83880494 198 - 1.086 0.507 -2.336
ENSG00000165115 E014 6.3666768 0.004495255 1.098796e-04 1.617272e-03 9 83883813 83884018 206 - 1.061 0.548 -2.055
ENSG00000165115 E015 4.9730098 0.005975232 9.638335e-06 2.029775e-04 9 83887041 83887196 156 - 1.009 0.355 -2.864
ENSG00000165115 E016 5.2993552 0.006339059 5.340350e-08 2.116980e-06 9 83888489 83888592 104 - 1.049 0.213 -4.011
ENSG00000165115 E017 6.4606185 0.004661136 5.055194e-08 2.013812e-06 9 83889084 83889253 170 - 1.119 0.355 -3.265
ENSG00000165115 E018 0.1779838 0.036518245 4.916788e-01   9 83889254 83889270 17 - 0.124 0.000 -9.473
ENSG00000165115 E019 6.1674566 0.011964889 5.244103e-06 1.200668e-04 9 83891295 83891501 207 - 1.074 0.412 -2.779
ENSG00000165115 E020 0.0000000       9 83898692 83898695 4 -      
ENSG00000165115 E021 0.0000000       9 83898696 83898948 253 -      
ENSG00000165115 E022 5.0794172 0.005862594 3.046865e-04 3.777396e-03 9 83899661 83899804 144 - 0.980 0.462 -2.172
ENSG00000165115 E023 11.4235429 0.002977636 8.236922e-09 3.943667e-07 9 83903060 83903507 448 - 1.310 0.681 -2.353
ENSG00000165115 E024 7.0160755 0.005084450 3.681190e-03 2.737327e-02 9 83903508 83903795 288 - 1.049 0.681 -1.426
ENSG00000165115 E025 6.4443897 0.004827461 4.179122e-04 4.905723e-03 9 83903796 83904018 223 - 1.049 0.585 -1.841
ENSG00000165115 E026 7.6498200 0.004357445 3.736852e-07 1.196687e-05 9 83908452 83908652 201 - 1.161 0.507 -2.607
ENSG00000165115 E027 10.6412303 0.003178226 7.040110e-10 4.221655e-08 9 83915294 83915678 385 - 1.296 0.585 -2.719
ENSG00000165115 E028 5.8805361 0.004962809 4.367044e-05 7.418471e-04 9 83919536 83919592 57 - 0.473 1.021 2.266
ENSG00000165115 E029 56.3266270 0.001193683 5.514362e-37 7.739384e-34 9 83919593 83919813 221 - 1.343 1.961 2.102
ENSG00000165115 E030 57.7608026 0.005488989 2.528680e-22 9.781961e-20 9 83920106 83920212 107 - 1.425 1.953 1.792
ENSG00000165115 E031 7.7837820 0.003803152 2.968807e-03 2.320996e-02 9 83920773 83920888 116 - 0.749 1.081 1.265
ENSG00000165115 E032 13.9362029 0.004421798 4.373032e-07 1.376536e-05 9 83920987 83921370 384 - 0.861 1.340 1.740
ENSG00000165115 E033 34.4272973 0.003507497 1.124681e-14 1.629665e-12 9 83921371 83921747 377 - 1.241 1.731 1.685