ENSG00000164985

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000380733 ENSG00000164985 HEK293_OSMI2_6hA HEK293_TMG_6hB PSIP1 protein_coding protein_coding 60.22164 32.81677 85.01164 7.911166 1.993389 1.372958 7.550537 5.913347 6.193785 3.1322099 3.8936371 0.06673615 0.10425833 0.14570000 0.07500000 -0.07070000 9.551317e-01 1.184062e-10 FALSE  
ENST00000380738 ENSG00000164985 HEK293_OSMI2_6hA HEK293_TMG_6hB PSIP1 protein_coding protein_coding 60.22164 32.81677 85.01164 7.911166 1.993389 1.372958 18.605647 6.217843 34.391039 1.2566531 3.7474550 2.46564759 0.30408750 0.22623333 0.40313333 0.17690000 4.573797e-01 1.184062e-10 FALSE  
ENST00000397519 ENSG00000164985 HEK293_OSMI2_6hA HEK293_TMG_6hB PSIP1 protein_coding protein_coding 60.22164 32.81677 85.01164 7.911166 1.993389 1.372958 17.282583 11.055150 26.187403 2.6389380 2.1548824 1.24340080 0.29936667 0.33993333 0.30733333 -0.03260000 8.325532e-01 1.184062e-10 FALSE  
ENST00000481862 ENSG00000164985 HEK293_OSMI2_6hA HEK293_TMG_6hB PSIP1 protein_coding protein_coding 60.22164 32.81677 85.01164 7.911166 1.993389 1.372958 5.879711 1.902290 6.999895 1.9022898 1.1557724 1.87409156 0.09457083 0.04743333 0.08193333 0.03450000 3.491838e-01 1.184062e-10    
ENST00000488797 ENSG00000164985 HEK293_OSMI2_6hA HEK293_TMG_6hB PSIP1 protein_coding processed_transcript 60.22164 32.81677 85.01164 7.911166 1.993389 1.372958 2.124814 3.013938 1.189712 0.4712873 0.1358868 -1.33374042 0.05687917 0.09770000 0.01406667 -0.08363333 1.184062e-10 1.184062e-10    
MSTRG.32427.8 ENSG00000164985 HEK293_OSMI2_6hA HEK293_TMG_6hB PSIP1 protein_coding   60.22164 32.81677 85.01164 7.911166 1.993389 1.372958 3.805376 3.633428 3.913824 1.4143984 0.6355207 0.10696394 0.07337917 0.10560000 0.04633333 -0.05926667 1.986990e-01 1.184062e-10 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000164985 E001 829.8511986 0.0050210901 9.671286e-01 9.855012e-01 9 15464066 15465555 1490 - 2.884 2.886 0.004
ENSG00000164985 E002 113.3255074 1.4397917369 5.983934e-01 7.691507e-01 9 15465556 15465580 25 - 2.001 2.071 0.233
ENSG00000164985 E003 207.8738494 0.0348561395 8.793014e-01 9.409474e-01 9 15466748 15466859 112 - 2.299 2.257 -0.140
ENSG00000164985 E004 312.1527280 0.0010963719 3.447708e-04 4.186031e-03 9 15468630 15468819 190 - 2.491 2.400 -0.304
ENSG00000164985 E005 167.6575395 0.0003179604 3.001050e-05 5.398806e-04 9 15468820 15468843 24 - 2.228 2.105 -0.412
ENSG00000164985 E006 207.6111642 0.0003401829 4.748904e-06 1.100386e-04 9 15468957 15469058 102 - 2.322 2.199 -0.410
ENSG00000164985 E007 166.5180313 0.0006600329 2.584132e-05 4.744783e-04 9 15469266 15469336 71 - 2.229 2.098 -0.440
ENSG00000164985 E008 179.4381235 0.0003225521 3.035809e-03 2.362850e-02 9 15469938 15469993 56 - 2.250 2.168 -0.273
ENSG00000164985 E009 1.2017038 0.0209665601 2.864064e-02   9 15470636 15470645 10 - 0.154 0.539 2.531
ENSG00000164985 E010 10.4384451 0.0248073065 5.482001e-03 3.711802e-02 9 15470646 15470684 39 - 0.890 1.236 1.262
ENSG00000164985 E011 52.2451682 0.0248669313 8.714230e-03 5.254711e-02 9 15470685 15470801 117 - 1.591 1.861 0.915
ENSG00000164985 E012 159.2586259 0.0003825195 1.209302e-15 2.003584e-13 9 15470802 15470989 188 - 2.085 2.327 0.809
ENSG00000164985 E013 225.6045604 0.0003423857 2.880499e-16 5.143795e-14 9 15470990 15471176 187 - 2.249 2.461 0.705
ENSG00000164985 E014 86.8756805 0.0004326243 1.730028e-03 1.523061e-02 9 15471177 15471231 55 - 1.868 1.999 0.440
ENSG00000164985 E015 10.2762206 0.0040227620 7.429314e-01 8.622901e-01 9 15471232 15471311 80 - 1.024 0.992 -0.117
ENSG00000164985 E016 28.8776807 0.0062523645 3.144696e-02 1.316341e-01 9 15472081 15472631 551 - 1.488 1.313 -0.604
ENSG00000164985 E017 436.4948897 0.0020372996 5.698053e-02 1.960096e-01 9 15472632 15472750 119 - 2.590 2.648 0.192
ENSG00000164985 E018 602.9668565 0.0034808686 3.963041e-01 6.253865e-01 9 15474009 15474237 229 - 2.740 2.767 0.090
ENSG00000164985 E019 369.2081694 0.0005372735 3.630876e-01 5.982105e-01 9 15478477 15478552 76 - 2.541 2.528 -0.043
ENSG00000164985 E020 422.3650285 0.0001621803 6.724927e-01 8.178899e-01 9 15479591 15479687 97 - 2.596 2.595 -0.003
ENSG00000164985 E021 1.7689339 0.0116649398 9.861398e-03 5.752979e-02 9 15485903 15486005 103 - 0.523 0.000 -11.723
ENSG00000164985 E022 387.7416126 0.0001892741 7.012322e-02 2.250375e-01 9 15486006 15486068 63 - 2.566 2.536 -0.099
ENSG00000164985 E023 430.5471475 0.0002219173 4.883669e-04 5.569535e-03 9 15486827 15486931 105 - 2.620 2.558 -0.204
ENSG00000164985 E024 5.8504721 0.0933412712 1.749216e-01 3.970609e-01 9 15489270 15489440 171 - 0.874 0.592 -1.154
ENSG00000164985 E025 404.1956323 0.0013757113 1.089232e-03 1.059431e-02 9 15489986 15490124 139 - 2.596 2.517 -0.266
ENSG00000164985 E026 32.3399162 0.0180171192 5.517290e-19 1.400542e-16 9 15491952 15492225 274 - 1.067 1.868 2.771
ENSG00000164985 E027 0.8158242 0.0172671820 6.152958e-01   9 15504959 15506560 1602 - 0.267 0.173 -0.794
ENSG00000164985 E028 256.5331229 0.0009378511 8.746343e-01 9.385320e-01 9 15506561 15506637 77 - 2.378 2.378 0.002
ENSG00000164985 E029 186.0359001 0.0002947505 1.741736e-01 3.960989e-01 9 15510117 15510326 210 - 2.225 2.270 0.149
ENSG00000164985 E030 3.4259826 0.1949918529 2.728370e-02 1.191320e-01 9 15510327 15510329 3 - 0.361 0.942 2.579
ENSG00000164985 E031 10.9428374 0.0281780390 3.848485e-04 4.586073e-03 9 15510817 15511025 209 - 0.856 1.323 1.696
ENSG00000164985 E032 0.3503582 0.0626068491 5.411748e-01   9 15511026 15511381 356 - 0.084 0.173 1.204