ENSG00000164930

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000358755 ENSG00000164930 HEK293_OSMI2_6hA HEK293_TMG_6hB FZD6 protein_coding protein_coding 7.83295 1.284642 14.16203 0.1226736 0.1956892 3.452422 5.06443537 0.6686806 8.642441 0.34849591 0.7706085 3.672303 0.65431667 0.5445000 0.6093333 0.06483333 1.000000e+00 7.555205e-06 FALSE TRUE
ENST00000519011 ENSG00000164930 HEK293_OSMI2_6hA HEK293_TMG_6hB FZD6 protein_coding nonsense_mediated_decay 7.83295 1.284642 14.16203 0.1226736 0.1956892 3.452422 0.01775508 0.1420407 0.000000 0.14204068 0.0000000 -3.926385 0.01263750 0.1011000 0.0000000 -0.10110000 5.757777e-01 7.555205e-06 FALSE TRUE
ENST00000522484 ENSG00000164930 HEK293_OSMI2_6hA HEK293_TMG_6hB FZD6 protein_coding nonsense_mediated_decay 7.83295 1.284642 14.16203 0.1226736 0.1956892 3.452422 0.75862385 0.1269850 1.848572 0.06882362 0.1897294 3.762105 0.07566250 0.1022333 0.1309333 0.02870000 8.998974e-01 7.555205e-06 TRUE TRUE
ENST00000523739 ENSG00000164930 HEK293_OSMI2_6hA HEK293_TMG_6hB FZD6 protein_coding protein_coding 7.83295 1.284642 14.16203 0.1226736 0.1956892 3.452422 0.08770161 0.2466631 0.000000 0.24666308 0.0000000 -4.681804 0.05992917 0.1755667 0.0000000 -0.17556667 6.228303e-01 7.555205e-06 FALSE TRUE
ENST00000523933 ENSG00000164930 HEK293_OSMI2_6hA HEK293_TMG_6hB FZD6 protein_coding nonsense_mediated_decay 7.83295 1.284642 14.16203 0.1226736 0.1956892 3.452422 1.75855032 0.0000000 3.600944 0.00000000 0.5800219 8.496232 0.12510833 0.0000000 0.2547667 0.25476667 7.555205e-06 7.555205e-06 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000164930 E001 0.1426347 0.0317650269 6.777384e-01   8 103298433 103298570 138 + 0.046 0.001 -6.226
ENSG00000164930 E002 1.2459410 0.1380934163 8.557242e-01   8 103298831 103298858 28 + 0.250 0.286 0.264
ENSG00000164930 E003 1.8706098 0.0281205846 7.981054e-01 0.8952341128 8 103298859 103298864 6 + 0.348 0.286 -0.401
ENSG00000164930 E004 2.1746602 0.0669733752 6.851532e-01 0.8259843976 8 103298865 103298875 11 + 0.388 0.286 -0.634
ENSG00000164930 E005 11.9560346 0.0126998636 4.809234e-01 0.6877224231 8 103298876 103298897 22 + 0.931 0.819 -0.430
ENSG00000164930 E006 33.3733500 0.0052599122 9.210756e-02 0.2676115483 8 103298898 103298995 98 + 1.353 1.175 -0.627
ENSG00000164930 E007 0.0000000       8 103299954 103299955 2 +      
ENSG00000164930 E008 51.5822144 0.0007912680 4.699360e-01 0.6800271183 8 103299956 103300084 129 + 1.528 1.474 -0.183
ENSG00000164930 E009 43.8052242 0.0063693411 3.263563e-02 0.1350589757 8 103300085 103300199 115 + 1.477 1.270 -0.719
ENSG00000164930 E010 39.6628761 0.0050028011 9.294114e-02 0.2692013307 8 103300200 103300284 85 + 1.432 1.270 -0.563
ENSG00000164930 E011 0.8274031 0.0171738556 5.259287e-01   8 103307751 103307880 130 + 0.161 0.286 1.056
ENSG00000164930 E012 57.8098007 0.0008916530 5.966034e-02 0.2020080015 8 103318590 103318786 197 + 1.588 1.446 -0.486
ENSG00000164930 E013 114.0167979 0.0005445811 6.439199e-01 0.7994649673 8 103324481 103325034 554 + 1.858 1.882 0.083
ENSG00000164930 E014 25.1900311 0.0018950193 5.892604e-01 0.7631763468 8 103325035 103325053 19 + 1.214 1.271 0.203
ENSG00000164930 E015 116.5895274 0.0003642901 8.262123e-01 0.9116002036 8 103325054 103325498 445 + 1.869 1.861 -0.028
ENSG00000164930 E016 68.8167640 0.0006464286 8.179512e-01 0.9069213422 8 103328268 103328416 149 + 1.645 1.632 -0.043
ENSG00000164930 E017 123.6274512 0.0009519699 5.790950e-01 0.7565751073 8 103329655 103330065 411 + 1.896 1.872 -0.082
ENSG00000164930 E018 168.4604877 0.0013150229 6.816870e-06 0.0001505411 8 103331341 103332866 1526 + 2.005 2.173 0.562