ENSG00000164924

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000353245 ENSG00000164924 HEK293_OSMI2_6hA HEK293_TMG_6hB YWHAZ protein_coding protein_coding 359.739 183.5154 500.5207 38.50599 23.28649 1.447479 146.02382 94.7261045 180.32600 24.4042156 10.0040267 0.9287012 0.44785833 0.50533333 0.36016667 -0.145166667 0.08570824 0.02593479 FALSE TRUE
ENST00000395953 ENSG00000164924 HEK293_OSMI2_6hA HEK293_TMG_6hB YWHAZ protein_coding protein_coding 359.739 183.5154 500.5207 38.50599 23.28649 1.447479 19.10219 0.3371987 31.67201 0.2329523 9.5284817 6.5117583 0.03722083 0.00280000 0.06176667 0.058966667 0.02593479 0.02593479 FALSE TRUE
ENST00000457309 ENSG00000164924 HEK293_OSMI2_6hA HEK293_TMG_6hB YWHAZ protein_coding protein_coding 359.739 183.5154 500.5207 38.50599 23.28649 1.447479 57.14770 26.8824503 71.20504 6.3751810 0.2546072 1.4049807 0.17033750 0.14413333 0.14293333 -0.001200000 1.00000000 0.02593479 FALSE TRUE
ENST00000522542 ENSG00000164924 HEK293_OSMI2_6hA HEK293_TMG_6hB YWHAZ protein_coding protein_coding 359.739 183.5154 500.5207 38.50599 23.28649 1.447479 47.03990 15.8480971 94.69234 3.6977205 5.0683510 2.5781805 0.10352500 0.09373333 0.18923333 0.095500000 0.22695721 0.02593479 FALSE TRUE
ENST00000523131 ENSG00000164924 HEK293_OSMI2_6hA HEK293_TMG_6hB YWHAZ protein_coding protein_coding 359.739 183.5154 500.5207 38.50599 23.28649 1.447479 63.40109 33.0994300 85.70643 6.8660877 1.4010685 1.3723295 0.17055417 0.18070000 0.17173333 -0.008966667 0.91144912 0.02593479   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000164924 E001 0.7381610 1.756571e-02 2.074348e-01   8 100916523 100916524 2 - 0.157 0.385 1.707
ENSG00000164924 E002 89.7932394 5.415666e-04 1.200797e-05 2.456223e-04 8 100916525 100918578 2054 - 1.856 2.042 0.623
ENSG00000164924 E003 196.8655498 4.316799e-04 1.619294e-01 3.796154e-01 8 100918579 100918682 104 - 2.245 2.298 0.178
ENSG00000164924 E004 183.7595404 2.974313e-04 1.674663e-01 3.872129e-01 8 100918683 100918685 3 - 2.216 2.268 0.176
ENSG00000164924 E005 2237.3245109 7.103544e-05 1.460461e-18 3.589288e-16 8 100918686 100919061 376 - 3.289 3.377 0.294
ENSG00000164924 E006 1801.0287445 6.553312e-04 4.625301e-14 6.146185e-12 8 100919062 100919229 168 - 3.179 3.307 0.425
ENSG00000164924 E007 3183.6239934 4.236096e-03 1.264634e-04 1.816799e-03 8 100919230 100919828 599 - 3.421 3.565 0.476
ENSG00000164924 E008 5409.7013591 1.647432e-04 2.292959e-06 5.881243e-05 8 100919829 100920525 697 - 3.686 3.735 0.162
ENSG00000164924 E009 1412.2612601 1.711103e-04 8.411165e-01 9.200882e-01 8 100920526 100920586 61 - 3.115 3.127 0.039
ENSG00000164924 E010 829.7380692 2.985834e-04 1.092942e-01 2.979483e-01 8 100920587 100920589 3 - 2.892 2.881 -0.037
ENSG00000164924 E011 1169.0021407 1.222427e-04 4.136547e-04 4.864489e-03 8 100920590 100920602 13 - 3.046 3.016 -0.098
ENSG00000164924 E012 1218.6644601 8.613588e-05 8.578835e-01 9.292652e-01 8 100920603 100920629 27 - 3.051 3.062 0.037
ENSG00000164924 E013 940.1550322 4.035905e-04 9.108108e-01 9.575334e-01 8 100920630 100920641 12 - 2.938 2.949 0.038
ENSG00000164924 E014 1593.7953405 8.789747e-05 1.798925e-02 8.899409e-02 8 100920642 100920715 74 - 3.175 3.164 -0.037
ENSG00000164924 E015 1440.9407992 1.099132e-04 3.861908e-05 6.690205e-04 8 100920716 100920752 37 - 3.139 3.106 -0.108
ENSG00000164924 E016 21.8539130 1.089400e-01 3.094172e-01 5.499221e-01 8 100922438 100923954 1517 - 1.374 1.211 -0.573
ENSG00000164924 E017 1322.8216142 1.560587e-04 2.373293e-11 1.913769e-09 8 100923955 100923984 30 - 3.112 3.045 -0.224
ENSG00000164924 E018 1058.1048343 8.534859e-05 4.542965e-12 4.174783e-10 8 100923985 100923986 2 - 3.017 2.943 -0.244
ENSG00000164924 E019 1657.2020073 9.076390e-05 2.652106e-09 1.416762e-07 8 100923987 100924050 64 - 3.204 3.156 -0.160
ENSG00000164924 E020 9.7022517 4.152630e-03 2.782570e-01 5.183795e-01 8 100924051 100924134 84 - 1.026 0.911 -0.429
ENSG00000164924 E021 2431.0359913 6.476052e-04 3.358371e-04 4.097188e-03 8 100924135 100924298 164 - 3.368 3.329 -0.128
ENSG00000164924 E022 3.3063809 2.697089e-02 1.685972e-02 8.493547e-02 8 100924299 100924322 24 - 0.439 0.828 1.714
ENSG00000164924 E023 1038.9413624 8.131394e-04 3.834599e-04 4.574341e-03 8 100924916 100924921 6 - 3.003 2.950 -0.177
ENSG00000164924 E024 1910.2907697 7.247182e-04 2.684129e-04 3.410856e-03 8 100924922 100925039 118 - 3.265 3.221 -0.146
ENSG00000164924 E025 0.1308682 3.264919e-02 2.287369e-01   8 100932029 100932093 65 - 0.000 0.169 9.819
ENSG00000164924 E026 0.4043710 6.622161e-02 2.418765e-01   8 100934857 100935055 199 - 0.086 0.289 2.115
ENSG00000164924 E027 0.3503582 4.830521e-02 5.798630e-01   8 100948077 100948162 86 - 0.086 0.169 1.124
ENSG00000164924 E028 989.8300358 4.986493e-04 5.973421e-03 3.959965e-02 8 100948596 100948613 18 - 2.976 2.945 -0.103
ENSG00000164924 E029 1394.8218350 7.575324e-05 4.700784e-07 1.467466e-05 8 100948614 100948662 49 - 3.127 3.086 -0.137
ENSG00000164924 E030 1460.9460528 9.241829e-05 7.361466e-05 1.158401e-03 8 100948663 100948732 70 - 3.144 3.114 -0.100
ENSG00000164924 E031 736.8085352 1.241914e-04 1.050634e-02 6.028397e-02 8 100948733 100948734 2 - 2.845 2.820 -0.084
ENSG00000164924 E032 1540.7057402 1.517705e-04 2.076430e-02 9.855656e-02 8 100948735 100948900 166 - 3.162 3.149 -0.042
ENSG00000164924 E033 10.0031091 6.577041e-02 8.951436e-01 9.492933e-01 8 100950406 100950557 152 - 1.025 1.014 -0.042
ENSG00000164924 E034 2.6132420 1.260515e-01 2.290397e-01 4.640165e-01 8 100950909 100951185 277 - 0.440 0.684 1.130
ENSG00000164924 E035 0.2735028 2.617790e-02 5.824938e-01   8 100951186 100951234 49 - 0.086 0.169 1.123
ENSG00000164924 E036 3.5661074 3.031626e-01 6.744387e-01 8.191735e-01 8 100951235 100951449 215 - 0.590 0.720 0.554
ENSG00000164924 E037 1.9700525 1.092764e-02 4.952926e-01 6.976630e-01 8 100951456 100951595 140 - 0.403 0.529 0.637
ENSG00000164924 E038 696.0541367 6.722993e-04 7.668679e-01 8.767457e-01 8 100951929 100951955 27 - 2.810 2.818 0.025
ENSG00000164924 E039 606.5738415 1.550987e-03 8.057557e-01 8.995553e-01 8 100951956 100952125 170 - 2.747 2.767 0.067
ENSG00000164924 E040 33.5811074 1.072277e-03 4.334242e-02 1.634477e-01 8 100952126 100952308 183 - 1.459 1.598 0.476
ENSG00000164924 E041 18.9993232 1.898312e-03 3.094698e-02 1.301997e-01 8 100952309 100952472 164 - 1.200 1.387 0.653
ENSG00000164924 E042 6.2724046 2.210469e-02 3.567498e-01 5.931324e-01 8 100952473 100952619 147 - 0.780 0.914 0.519
ENSG00000164924 E043 89.4548775 2.140899e-03 2.403681e-02 1.091912e-01 8 100952850 100953057 208 - 1.953 1.862 -0.305
ENSG00000164924 E044 52.8735975 9.193043e-01 5.062514e-01 7.051165e-01 8 100953269 100953388 120 - 1.662 1.776 0.385