ENSG00000164919

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000520271 ENSG00000164919 HEK293_OSMI2_6hA HEK293_TMG_6hB COX6C protein_coding protein_coding 391.5427 181.8533 499.948 5.486772 20.96088 1.458952 20.98221 18.80732 16.87279 0.8275344 1.182698 -0.1565074 0.06049167 0.1033667 0.03376667 -0.06960000 5.151248e-17 5.151248e-17 FALSE  
MSTRG.31918.1 ENSG00000164919 HEK293_OSMI2_6hA HEK293_TMG_6hB COX6C protein_coding   391.5427 181.8533 499.948 5.486772 20.96088 1.458952 347.41967 150.33335 456.08332 4.6140433 20.373948 1.6010680 0.87862917 0.8267000 0.91203333 0.08533333 4.557817e-09 5.151248e-17    
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000164919 E001 0.1308682 0.032314274 2.733265e-01   8 99854308 99854339 32 - 0.000 0.157 10.422
ENSG00000164919 E002 0.3040503 0.024441170 4.252236e-01   8 99873200 99873293 94 - 0.170 0.000 -12.760
ENSG00000164919 E003 0.4820342 0.022247717 2.291849e-01   8 99874828 99874875 48 - 0.235 0.000 -13.388
ENSG00000164919 E004 0.3503582 0.060646286 6.674489e-01   8 99874996 99875025 30 - 0.093 0.157 0.864
ENSG00000164919 E005 0.4929928 0.023735642 9.826466e-01   8 99875026 99875092 67 - 0.170 0.157 -0.134
ENSG00000164919 E006 0.1426347 0.031192077 8.259011e-01   8 99875093 99875095 3 - 0.093 0.000 -11.644
ENSG00000164919 E007 3.8376416 0.007588918 8.499550e-01 9.249568e-01 8 99877865 99878043 179 - 0.684 0.651 -0.136
ENSG00000164919 E008 7.5408308 0.004432727 8.890628e-01 9.462156e-01 8 99878044 99878139 96 - 0.912 0.924 0.046
ENSG00000164919 E009 13.9511595 0.056311560 9.552978e-01 9.795595e-01 8 99878140 99878147 8 - 1.157 1.169 0.044
ENSG00000164919 E010 14.3804685 0.041056835 9.185571e-01 9.614739e-01 8 99878148 99878148 1 - 1.164 1.194 0.109
ENSG00000164919 E011 17.7721268 0.048748677 2.106319e-01 4.425658e-01 8 99878149 99878149 1 - 1.184 1.373 0.661
ENSG00000164919 E012 18.4395193 0.039972988 1.328083e-01 3.362039e-01 8 99878150 99878150 1 - 1.191 1.397 0.721
ENSG00000164919 E013 498.3190619 0.033973507 2.385668e-01 4.749717e-01 8 99878151 99878265 115 - 2.708 2.628 -0.265
ENSG00000164919 E014 5.6272095 0.091317961 6.146247e-02 2.060555e-01 8 99878266 99878794 529 - 0.903 0.555 -1.437
ENSG00000164919 E015 15.6048440 0.165553863 4.394702e-01 6.582827e-01 8 99885992 99886382 391 - 1.101 1.346 0.868
ENSG00000164919 E016 1.7117830 0.065771605 2.445351e-01 4.817017e-01 8 99887061 99887489 429 - 0.498 0.271 -1.304
ENSG00000164919 E017 1621.0420814 0.026546844 1.846062e-01 4.099589e-01 8 99887490 99887598 109 - 3.214 3.152 -0.207
ENSG00000164919 E018 1243.1754661 0.012334109 1.946961e-01 4.229416e-01 8 99887599 99887618 20 - 3.093 3.049 -0.145
ENSG00000164919 E019 1969.3283962 0.001034656 5.489803e-01 7.356182e-01 8 99891908 99892047 140 - 3.281 3.274 -0.021
ENSG00000164919 E020 862.0904268 0.589119191 3.891648e-01 6.198336e-01 8 99892048 99892052 5 - 2.888 2.967 0.263
ENSG00000164919 E021 2.1493917 0.011680728 7.503084e-01 8.669395e-01 8 99893013 99893135 123 - 0.499 0.438 -0.303
ENSG00000164919 E022 18.0974029 0.042237358 2.299185e-08 9.945353e-07 8 99893319 99893442 124 - 0.868 1.575 2.518
ENSG00000164919 E023 104.9545849 0.637314272 4.137047e-02 1.582877e-01 8 99893443 99893638 196 - 1.694 2.290 2.000
ENSG00000164919 E024 818.4437328 1.845359822 5.973286e-01 7.685382e-01 8 99893639 99893707 69 - 2.876 2.928 0.172