ENSG00000164830

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000297447 ENSG00000164830 HEK293_OSMI2_6hA HEK293_TMG_6hB OXR1 protein_coding protein_coding 12.07855 6.521958 18.21409 0.1304001 1.084463 1.480259 0.8741517 0.2711414 1.1165390 0.08357669 0.22721568 2.0025297 0.06554583 0.04183333 0.060200000 0.01836667 7.779260e-01 9.871273e-10 FALSE TRUE
ENST00000312046 ENSG00000164830 HEK293_OSMI2_6hA HEK293_TMG_6hB OXR1 protein_coding protein_coding 12.07855 6.521958 18.21409 0.1304001 1.084463 1.480259 2.3242258 0.2349990 5.4938357 0.23499895 0.42530081 4.4895899 0.14342083 0.03520000 0.303466667 0.26826667 9.832814e-02 9.871273e-10 FALSE TRUE
ENST00000449762 ENSG00000164830 HEK293_OSMI2_6hA HEK293_TMG_6hB OXR1 protein_coding protein_coding 12.07855 6.521958 18.21409 0.1304001 1.084463 1.480259 1.6485142 0.3916288 3.1471399 0.11867742 0.22194258 2.9746836 0.12406667 0.05970000 0.172700000 0.11300000 3.111468e-02 9.871273e-10 FALSE TRUE
ENST00000521369 ENSG00000164830 HEK293_OSMI2_6hA HEK293_TMG_6hB OXR1 protein_coding processed_transcript 12.07855 6.521958 18.21409 0.1304001 1.084463 1.480259 0.3861342 0.4396639 0.1575038 0.16253348 0.15750376 -1.4246536 0.03532083 0.06826667 0.008266667 -0.06000000 2.247986e-01 9.871273e-10 FALSE FALSE
ENST00000577661 ENSG00000164830 HEK293_OSMI2_6hA HEK293_TMG_6hB OXR1 protein_coding processed_transcript 12.07855 6.521958 18.21409 0.1304001 1.084463 1.480259 0.2482133 0.9742741 0.0000000 0.50053846 0.00000000 -6.6209882 0.02704583 0.15143333 0.000000000 -0.15143333 2.053195e-01 9.871273e-10   FALSE
ENST00000658832 ENSG00000164830 HEK293_OSMI2_6hA HEK293_TMG_6hB OXR1 protein_coding processed_transcript 12.07855 6.521958 18.21409 0.1304001 1.084463 1.480259 1.2999743 0.6671205 1.2464636 0.66712053 0.16245584 0.8918842 0.13669167 0.10063333 0.068033333 -0.03260000 6.224041e-01 9.871273e-10   FALSE
ENST00000661818 ENSG00000164830 HEK293_OSMI2_6hA HEK293_TMG_6hB OXR1 protein_coding processed_transcript 12.07855 6.521958 18.21409 0.1304001 1.084463 1.480259 1.5827853 1.2214744 2.0661320 0.17877473 0.35292396 0.7535115 0.17384583 0.18640000 0.114300000 -0.07210000 4.769783e-01 9.871273e-10 FALSE FALSE
MSTRG.31987.15 ENSG00000164830 HEK293_OSMI2_6hA HEK293_TMG_6hB OXR1 protein_coding   12.07855 6.521958 18.21409 0.1304001 1.084463 1.480259 0.6309941 0.0000000 1.1085978 0.00000000 0.59019566 6.8055475 0.04140000 0.00000000 0.064200000 0.06420000 4.674719e-01 9.871273e-10 FALSE TRUE
MSTRG.31987.3 ENSG00000164830 HEK293_OSMI2_6hA HEK293_TMG_6hB OXR1 protein_coding   12.07855 6.521958 18.21409 0.1304001 1.084463 1.480259 0.9831732 1.3788860 0.8372406 0.26681369 0.44510941 -0.7130845 0.10352500 0.21073333 0.044233333 -0.16650000 3.370467e-02 9.871273e-10   FALSE
MSTRG.31987.8 ENSG00000164830 HEK293_OSMI2_6hA HEK293_TMG_6hB OXR1 protein_coding   12.07855 6.521958 18.21409 0.1304001 1.084463 1.480259 0.3421482 0.0000000 1.4548965 0.00000000 0.02065405 7.1946550 0.01892917 0.00000000 0.080400000 0.08040000 9.871273e-10 9.871273e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000164830 E001 0.4576437 0.1630401013 5.315099e-01   8 106270144 106270189 46 + 0.107 0.240 1.394
ENSG00000164830 E002 0.9941679 0.0183100158 9.102091e-02   8 106270190 106270219 30 + 0.154 0.506 2.378
ENSG00000164830 E003 0.9941679 0.0183100158 9.102091e-02   8 106270220 106270222 3 + 0.154 0.506 2.378
ENSG00000164830 E004 1.0245278 0.0376867415 9.401249e-02   8 106270223 106270235 13 + 0.154 0.507 2.386
ENSG00000164830 E005 3.4055178 0.0068784914 2.996665e-07 9.844998e-06 8 106270236 106270289 54 + 0.267 1.080 3.695
ENSG00000164830 E006 3.4055178 0.0068784914 2.996665e-07 9.844998e-06 8 106270290 106270290 1 + 0.267 1.080 3.695
ENSG00000164830 E007 10.7323441 0.0028235933 1.159082e-16 2.196862e-14 8 106270291 106270367 77 + 0.615 1.523 3.373
ENSG00000164830 E008 7.9747155 0.0037177119 4.048086e-10 2.525562e-08 8 106271705 106271805 101 + 0.584 1.362 2.957
ENSG00000164830 E009 18.6342763 0.0176024091 6.954955e-14 8.934276e-12 8 106271806 106271957 152 + 0.885 1.703 2.893
ENSG00000164830 E010 110.1592493 0.0269706148 5.745028e-21 1.894442e-18 8 106271958 106272902 945 + 1.633 2.453 2.752
ENSG00000164830 E011 1.3651447 0.0392191623 9.861981e-04   8 106359476 106359548 73 + 0.108 0.734 3.963
ENSG00000164830 E012 2.5602820 0.0147681826 6.568930e-02 2.154705e-01 8 106359549 106359636 88 + 0.357 0.734 1.793
ENSG00000164830 E013 0.1779838 0.0330180412 1.000000e+00   8 106447924 106448048 125 + 0.058 0.001 -6.649
ENSG00000164830 E014 5.4175474 0.0054245460 5.530695e-02 1.920146e-01 8 106518943 106519139 197 + 0.615 0.958 1.374
ENSG00000164830 E015 0.0000000       8 106580974 106581003 30 +      
ENSG00000164830 E016 0.0000000       8 106581004 106581251 248 +      
ENSG00000164830 E017 0.0000000       8 106604782 106605204 423 +      
ENSG00000164830 E018 0.0000000       8 106618126 106618183 58 +      
ENSG00000164830 E019 0.3453689 0.0275415226 2.888292e-01   8 106657668 106657853 186 + 0.058 0.239 2.377
ENSG00000164830 E020 0.4161375 0.1227937601 5.393548e-01   8 106657854 106657866 13 + 0.108 0.238 1.373
ENSG00000164830 E021 3.5740024 0.0828802233 4.473639e-01 6.637778e-01 8 106657867 106657890 24 + 0.519 0.728 0.918
ENSG00000164830 E022 17.2174506 0.0223101633 2.623296e-01 5.015215e-01 8 106657891 106658085 195 + 1.148 1.079 -0.249
ENSG00000164830 E023 13.3677661 0.0030576612 2.876740e-01 5.283990e-01 8 106658086 106658185 100 + 1.044 0.992 -0.191
ENSG00000164830 E024 22.3609514 0.0016258057 1.015598e-01 2.846258e-01 8 106679210 106679292 83 + 1.255 1.175 -0.285
ENSG00000164830 E025 0.0000000       8 106682493 106682545 53 +      
ENSG00000164830 E026 30.5084868 0.0011716985 1.419103e-03 1.303528e-02 8 106683199 106683306 108 + 1.402 1.196 -0.722
ENSG00000164830 E027 33.3841061 0.0013277019 1.547290e-06 4.160143e-05 8 106684246 106684359 114 + 1.455 1.080 -1.320
ENSG00000164830 E028 35.6367918 0.0013479147 3.137479e-05 5.613318e-04 8 106692728 106692877 150 + 1.478 1.195 -0.984
ENSG00000164830 E029 30.4967703 0.0357828920 8.995972e-03 5.379769e-02 8 106702906 106703090 185 + 1.410 1.165 -0.857
ENSG00000164830 E030 0.0000000       8 106706381 106706381 1 +      
ENSG00000164830 E031 139.8705243 0.0116530466 3.489010e-04 4.228317e-03 8 106706382 106707145 764 + 2.042 1.900 -0.477
ENSG00000164830 E032 4.4148195 0.0062675515 1.474346e-02 7.712480e-02 8 106707146 106707690 545 + 0.533 0.958 1.744
ENSG00000164830 E033 46.1251973 0.0009432476 4.658734e-04 5.363071e-03 8 106710622 106710790 169 + 1.573 1.402 -0.589
ENSG00000164830 E034 48.4030481 0.0011276298 4.531738e-03 3.210892e-02 8 106713823 106713985 163 + 1.586 1.472 -0.392
ENSG00000164830 E035 0.0000000       8 106726012 106726106 95 +      
ENSG00000164830 E036 7.8808889 0.0036549290 3.918682e-01 6.219100e-01 8 106726107 106726184 78 + 0.842 0.788 -0.212
ENSG00000164830 E037 17.3509450 0.0022361574 2.465406e-01 4.841998e-01 8 106726185 106726257 73 + 1.152 1.106 -0.165
ENSG00000164830 E038 17.8497350 0.0022078505 1.222583e-01 3.194185e-01 8 106726258 106726309 52 + 1.169 1.080 -0.319
ENSG00000164830 E039 18.1373713 0.0022089045 5.861334e-01 7.610359e-01 8 106737520 106737600 81 + 1.152 1.175 0.082
ENSG00000164830 E040 69.8176826 0.0006637717 6.533672e-04 7.036832e-03 8 106739458 106739583 126 + 1.738 1.625 -0.385
ENSG00000164830 E041 0.0000000       8 106740243 106740342 100 +      
ENSG00000164830 E042 83.4425260 0.0017804055 2.844448e-06 7.094328e-05 8 106740343 106740495 153 + 1.825 1.640 -0.627
ENSG00000164830 E043 66.0392440 0.0018632085 8.737479e-04 8.881388e-03 8 106742222 106742317 96 + 1.717 1.594 -0.419
ENSG00000164830 E044 1.0939410 0.0551287054 3.563673e-02   8 106742318 106742484 167 + 0.154 0.593 2.775
ENSG00000164830 E045 62.2172891 0.0056630144 8.962431e-03 5.364591e-02 8 106745789 106745862 74 + 1.691 1.592 -0.336
ENSG00000164830 E046 272.6036713 0.0021567462 1.652284e-05 3.247637e-04 8 106750806 106752694 1889 + 2.317 2.265 -0.172