ENSG00000164751

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000357039 ENSG00000164751 HEK293_OSMI2_6hA HEK293_TMG_6hB PEX2 protein_coding protein_coding 14.90997 2.371246 26.70437 0.149655 0.7061602 3.487828 1.108116 0.42466982 2.060080 0.11130079 0.1577395 2.251695 0.08218750 0.17700000 0.07696667 -0.1000333 1.652931e-01 7.628113e-07 FALSE TRUE
ENST00000518986 ENSG00000164751 HEK293_OSMI2_6hA HEK293_TMG_6hB PEX2 protein_coding protein_coding 14.90997 2.371246 26.70437 0.149655 0.7061602 3.487828 1.698436 0.00000000 3.317816 0.00000000 0.3333590 8.378432 0.07066667 0.00000000 0.12420000 0.1242000 7.628113e-07 7.628113e-07 FALSE FALSE
ENST00000519956 ENSG00000164751 HEK293_OSMI2_6hA HEK293_TMG_6hB PEX2 protein_coding protein_coding 14.90997 2.371246 26.70437 0.149655 0.7061602 3.487828 2.752192 0.09257763 4.743476 0.09257763 0.1076384 5.534195 0.13419583 0.04406667 0.17770000 0.1336333 3.001211e-01 7.628113e-07   FALSE
ENST00000522527 ENSG00000164751 HEK293_OSMI2_6hA HEK293_TMG_6hB PEX2 protein_coding protein_coding 14.90997 2.371246 26.70437 0.149655 0.7061602 3.487828 8.431859 1.73364456 14.683817 0.11359407 0.4682448 3.075031 0.63625000 0.73090000 0.54973333 -0.1811667 8.295157e-03 7.628113e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000164751 E001 54.3692533 0.0007772682 0.0004749274 0.005449199 8 76980258 76982933 2676 - 1.541 1.752 0.716
ENSG00000164751 E002 14.7787414 0.0037098067 0.0754301636 0.235725218 8 76982934 76982956 23 - 1.007 1.208 0.724
ENSG00000164751 E003 193.7068297 0.0002986875 0.0706323201 0.225983769 8 76982957 76983639 683 - 2.113 2.170 0.193
ENSG00000164751 E004 143.7129642 0.0003517164 0.8696406290 0.935661853 8 76983640 76983949 310 - 1.993 1.986 -0.022
ENSG00000164751 E005 120.4367233 0.0004065413 0.3155473170 0.555566762 8 76983950 76984169 220 - 1.921 1.875 -0.154
ENSG00000164751 E006 56.7215429 0.0006559661 0.1112889875 0.301118949 8 76984170 76984193 24 - 1.607 1.495 -0.384
ENSG00000164751 E007 48.2960192 0.0029065320 0.2359730729 0.471943367 8 76984194 76984195 2 - 1.540 1.445 -0.323
ENSG00000164751 E008 95.4063093 0.0004113602 0.0388311511 0.151693563 8 76986187 76986296 110 - 1.829 1.718 -0.375
ENSG00000164751 E009 1.2429203 0.0153129653 0.0807081755   8 76986494 76986527 34 - 0.209 0.547 2.027
ENSG00000164751 E010 1.1961824 0.2797545350 0.4735224569   8 76987892 76988306 415 - 0.277 0.001 -9.040
ENSG00000164751 E011 42.0463502 0.0010628862 0.4717346117 0.681332317 8 76988307 76988338 32 - 1.476 1.419 -0.199
ENSG00000164751 E012 69.4519217 0.0007831491 0.3605730581 0.596094458 8 76999990 77000132 143 - 1.690 1.634 -0.192
ENSG00000164751 E013 5.8819364 0.0292228581 0.1831420531 0.408003947 8 77000133 77000267 135 - 0.671 0.887 0.865
ENSG00000164751 E014 1.2457534 0.0190113895 0.3564281274   8 77000332 77000367 36 - 0.241 0.428 1.181
ENSG00000164751 E015 0.8026527 0.0174142996 0.6048720567   8 77000883 77001186 304 - 0.209 0.000 -9.446