ENSG00000164631

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000404360 ENSG00000164631 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF12 protein_coding protein_coding 6.626162 2.764196 11.72784 0.1994432 1.265708 2.081026 1.0482893 0.8920834 2.4802639 0.19243359 0.86780054 1.464966 0.20761667 0.31733333 0.20043333 -0.1169000 6.295143e-01 2.805076e-10 FALSE TRUE
ENST00000405858 ENSG00000164631 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF12 protein_coding protein_coding 6.626162 2.764196 11.72784 0.1994432 1.265708 2.081026 4.5769971 0.6662959 8.5334623 0.21427086 0.56542493 3.659094 0.52804583 0.24776667 0.73876667 0.4910000 1.494648e-02 2.805076e-10 FALSE TRUE
ENST00000491565 ENSG00000164631 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF12 protein_coding processed_transcript 6.626162 2.764196 11.72784 0.1994432 1.265708 2.081026 0.5470640 0.9362237 0.3966270 0.05029768 0.10731579 -1.218475 0.17087500 0.34470000 0.03276667 -0.3119333 2.805076e-10 2.805076e-10 TRUE FALSE
MSTRG.29481.3 ENSG00000164631 HEK293_OSMI2_6hA HEK293_TMG_6hB ZNF12 protein_coding   6.626162 2.764196 11.72784 0.1994432 1.265708 2.081026 0.3458509 0.2695927 0.1241358 0.16565117 0.05250714 -1.059632 0.08355417 0.09026667 0.01196667 -0.0783000 5.209873e-01 2.805076e-10 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000164631 E001 14.184305 0.003052957 6.489344e-01 0.8028127126 7 6688433 6688573 141 - 1.116 1.059 -0.209
ENSG00000164631 E002 148.439721 0.597279577 2.151645e-01 0.4477393175 7 6688574 6689468 895 - 2.045 2.191 0.489
ENSG00000164631 E003 99.316962 0.464612316 3.178721e-01 0.5578365741 7 6689469 6690448 980 - 1.891 1.963 0.244
ENSG00000164631 E004 234.792546 1.105539069 6.172106e-01 0.7819096466 7 6690449 6692222 1774 - 2.290 2.219 -0.237
ENSG00000164631 E005 48.234905 0.292735835 8.261456e-01 0.9115565047 7 6692223 6692487 265 - 1.638 1.388 -0.858
ENSG00000164631 E006 29.529214 0.208636942 5.332242e-01 0.7243545189 7 6692488 6692601 114 - 1.437 1.167 -0.942
ENSG00000164631 E007 35.460391 0.140933396 9.898834e-01 0.9966677636 7 6692602 6692703 102 - 1.493 1.368 -0.430
ENSG00000164631 E008 21.521159 0.001803099 6.384561e-01 0.7960159406 7 6697339 6697372 34 - 1.285 1.239 -0.164
ENSG00000164631 E009 27.840924 0.116286835 3.440651e-01 0.5816617613 7 6697373 6697434 62 - 1.379 1.333 -0.160
ENSG00000164631 E010 18.277625 0.186307601 3.409470e-01 0.5788964525 7 6697685 6697688 4 - 1.209 1.141 -0.239
ENSG00000164631 E011 31.418149 0.258343841 2.387722e-01 0.4752023220 7 6697689 6697811 123 - 1.441 1.310 -0.457
ENSG00000164631 E012 2.284614 0.011317898 4.131165e-05 0.0007074386 7 6700821 6700914 94 - 0.214 0.877 3.358
ENSG00000164631 E013 7.095700 0.205956567 1.399451e-02 0.0743218482 7 6704160 6704311 152 - 0.571 1.268 2.686
ENSG00000164631 E014 21.984153 0.357435022 6.430710e-01 0.7988723619 7 6705159 6705223 65 - 1.264 1.290 0.091
ENSG00000164631 E015 33.386571 0.422639108 9.254312e-01 0.9648719817 7 6706432 6706947 516 - 1.398 1.585 0.640