ENSG00000164542

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000297063 ENSG00000164542 HEK293_OSMI2_6hA HEK293_TMG_6hB KIAA0895 protein_coding protein_coding 6.930316 1.926758 13.04851 0.5897514 0.4680096 2.753274 0.5214329 0.2808588 1.3203512 0.28085882 0.70724987 2.193416 0.11663750 0.09450000 0.09880000 0.00430000 0.88094105 0.02584414 FALSE TRUE
ENST00000317020 ENSG00000164542 HEK293_OSMI2_6hA HEK293_TMG_6hB KIAA0895 protein_coding protein_coding 6.930316 1.926758 13.04851 0.5897514 0.4680096 2.753274 1.6615413 0.6465645 3.0046314 0.08597976 1.55382916 2.198973 0.19974583 0.38200000 0.22770000 -0.15430000 0.83254911 0.02584414 FALSE TRUE
ENST00000338533 ENSG00000164542 HEK293_OSMI2_6hA HEK293_TMG_6hB KIAA0895 protein_coding protein_coding 6.930316 1.926758 13.04851 0.5897514 0.4680096 2.753274 0.8104138 0.0000000 1.3798194 0.00000000 0.95546756 7.118754 0.12910833 0.00000000 0.11010000 0.11010000 0.63509498 0.02584414 FALSE TRUE
ENST00000415803 ENSG00000164542 HEK293_OSMI2_6hA HEK293_TMG_6hB KIAA0895 protein_coding protein_coding 6.930316 1.926758 13.04851 0.5897514 0.4680096 2.753274 0.2442268 0.1524235 0.3153880 0.03262803 0.06562567 1.002401 0.06087500 0.08443333 0.02446667 -0.05996667 0.09208340 0.02584414 FALSE TRUE
ENST00000436884 ENSG00000164542 HEK293_OSMI2_6hA HEK293_TMG_6hB KIAA0895 protein_coding protein_coding 6.930316 1.926758 13.04851 0.5897514 0.4680096 2.753274 0.7528318 0.0195575 1.5171267 0.01955750 0.35192857 5.691152 0.07145000 0.02100000 0.11643333 0.09543333 0.04704194 0.02584414 FALSE TRUE
ENST00000440378 ENSG00000164542 HEK293_OSMI2_6hA HEK293_TMG_6hB KIAA0895 protein_coding protein_coding 6.930316 1.926758 13.04851 0.5897514 0.4680096 2.753274 1.1235700 0.4965459 1.6423767 0.22783632 0.94871627 1.705778 0.24473333 0.30036667 0.12680000 -0.17356667 0.76282893 0.02584414 FALSE TRUE
ENST00000453212 ENSG00000164542 HEK293_OSMI2_6hA HEK293_TMG_6hB KIAA0895 protein_coding protein_coding 6.930316 1.926758 13.04851 0.5897514 0.4680096 2.753274 0.4033745 0.0000000 1.2940472 0.00000000 0.61439816 7.026852 0.03257500 0.00000000 0.09630000 0.09630000 0.02584414 0.02584414 FALSE TRUE
ENST00000483360 ENSG00000164542 HEK293_OSMI2_6hA HEK293_TMG_6hB KIAA0895 protein_coding processed_transcript 6.930316 1.926758 13.04851 0.5897514 0.4680096 2.753274 0.6299672 0.1743410 1.5692445 0.17434099 0.28653584 3.098786 0.06221250 0.05866667 0.12183333 0.06316667 0.59685823 0.02584414 FALSE FALSE
MSTRG.29732.8 ENSG00000164542 HEK293_OSMI2_6hA HEK293_TMG_6hB KIAA0895 protein_coding   6.930316 1.926758 13.04851 0.5897514 0.4680096 2.753274 0.4151754 0.0000000 0.6506083 0.00000000 0.42054673 6.045723 0.04034583 0.00000000 0.05010000 0.05010000 0.69404184 0.02584414 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000164542 E001 1.3272930 0.052059844 0.107226012   7 36324152 36324220 69 - 0.236 0.584 1.971
ENSG00000164542 E002 1.1846583 0.018458520 0.057093476   7 36324221 36324222 2 - 0.199 0.585 2.292
ENSG00000164542 E003 1.3272930 0.052059844 0.107226012   7 36324223 36324229 7 - 0.236 0.584 1.971
ENSG00000164542 E004 206.1561997 1.532367334 0.400847465 0.62897881 7 36324230 36326495 2266 - 2.139 2.396 0.858
ENSG00000164542 E005 23.5055442 0.512983145 0.485904540 0.69119620 7 36326496 36326565 70 - 1.252 1.371 0.415
ENSG00000164542 E006 33.6713207 0.617734905 0.494761636 0.69726621 7 36326566 36326704 139 - 1.403 1.508 0.359
ENSG00000164542 E007 54.7443571 0.791648045 0.530517456 0.72242277 7 36326705 36326918 214 - 1.616 1.682 0.225
ENSG00000164542 E008 36.5595712 0.026710689 0.055657823 0.19283455 7 36330982 36331079 98 - 1.487 1.319 -0.581
ENSG00000164542 E009 0.3040503 0.024441170 1.000000000   7 36333855 36333855 1 - 0.111 0.000 -12.841
ENSG00000164542 E010 49.2694667 0.039247449 0.035993311 0.14419996 7 36333856 36334042 187 - 1.605 1.459 -0.502
ENSG00000164542 E011 38.0164964 0.065302905 0.142294677 0.35085677 7 36334043 36334134 92 - 1.487 1.388 -0.341
ENSG00000164542 E012 26.3886603 0.051817407 0.132267578 0.33536946 7 36334135 36334161 27 - 1.335 1.230 -0.369
ENSG00000164542 E013 44.0729701 0.053406232 0.121246739 0.31785250 7 36335046 36335178 133 - 1.549 1.463 -0.293
ENSG00000164542 E014 17.2947396 0.062539259 0.106948961 0.29391840 7 36336154 36336297 144 - 1.176 1.008 -0.607
ENSG00000164542 E015 5.2989255 0.005001732 0.002935758 0.02301432 7 36355196 36356146 951 - 0.576 1.041 1.853
ENSG00000164542 E016 4.3807031 0.013431885 0.056772885 0.19545844 7 36356147 36356367 221 - 0.559 0.909 1.440
ENSG00000164542 E017 7.3103331 0.071491729 0.079741186 0.24430477 7 36356368 36356901 534 - 0.727 1.094 1.398
ENSG00000164542 E018 17.9319112 0.055884046 0.933662852 0.96896307 7 36356902 36356944 43 - 1.139 1.249 0.392
ENSG00000164542 E019 40.8688906 0.084531163 0.290488491 0.53113865 7 36356945 36357191 247 - 1.508 1.472 -0.126
ENSG00000164542 E020 46.1254962 0.114925606 0.075738469 0.23625315 7 36357192 36357590 399 - 1.585 1.373 -0.729
ENSG00000164542 E021 0.9265063 0.271292327 0.313053047   7 36366704 36366915 212 - 0.270 0.000 -14.410
ENSG00000164542 E022 15.6718484 0.130153463 0.783103890 0.88648904 7 36366916 36367110 195 - 1.099 1.144 0.162
ENSG00000164542 E023 15.0094977 0.164857566 0.615818584 0.78086852 7 36367111 36367269 159 - 1.088 1.084 -0.015
ENSG00000164542 E024 0.1426347 0.031462568 1.000000000   7 36368200 36368357 158 - 0.059 0.000 -11.840
ENSG00000164542 E025 0.1614157 0.032306161 1.000000000   7 36383859 36383928 70 - 0.059 0.000 -11.842
ENSG00000164542 E026 0.5778428 0.098979028 0.004693340   7 36389967 36390125 159 - 0.000 0.502 18.001