ENSG00000164362

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000310581 ENSG00000164362 HEK293_OSMI2_6hA HEK293_TMG_6hB TERT protein_coding protein_coding 3.216047 4.403447 1.943279 0.376825 0.2827244 -1.176008 0.3849443 0.6489421 0.1506643 0.17140957 0.15066431 -2.03610228 0.11974583 0.15406667 0.1041667 -0.049900000 0.60376055 0.01612883 FALSE TRUE
ENST00000484238 ENSG00000164362 HEK293_OSMI2_6hA HEK293_TMG_6hB TERT protein_coding retained_intron 3.216047 4.403447 1.943279 0.376825 0.2827244 -1.176008 0.8053989 0.9962902 0.3914279 0.36234016 0.10604412 -1.32583357 0.25150000 0.22470000 0.2271667 0.002466667 1.00000000 0.01612883 FALSE TRUE
ENST00000503656 ENSG00000164362 HEK293_OSMI2_6hA HEK293_TMG_6hB TERT protein_coding retained_intron 3.216047 4.403447 1.943279 0.376825 0.2827244 -1.176008 0.9154460 1.5752172 0.6379084 0.11932797 0.22619252 -1.29081881 0.27124583 0.36390000 0.3071000 -0.056800000 0.91287431 0.01612883   FALSE
ENST00000656021 ENSG00000164362 HEK293_OSMI2_6hA HEK293_TMG_6hB TERT protein_coding nonsense_mediated_decay 3.216047 4.403447 1.943279 0.376825 0.2827244 -1.176008 0.2639302 0.3175984 0.2428695 0.04413302 0.03200272 -0.37353560 0.08833333 0.07140000 0.1259667 0.054566667 0.50708788 0.01612883 FALSE TRUE
MSTRG.25879.4 ENSG00000164362 HEK293_OSMI2_6hA HEK293_TMG_6hB TERT protein_coding   3.216047 4.403447 1.943279 0.376825 0.2827244 -1.176008 0.1794953 0.2603908 0.2543276 0.26039083 0.13831331 -0.03271926 0.06564583 0.05200000 0.1142667 0.062266667 0.70121815 0.01612883 TRUE TRUE
MSTRG.25879.5 ENSG00000164362 HEK293_OSMI2_6hA HEK293_TMG_6hB TERT protein_coding   3.216047 4.403447 1.943279 0.376825 0.2827244 -1.176008 0.1636019 0.1442818 0.1175226 0.14428180 0.11752258 -0.27481524 0.05697083 0.02883333 0.0600000 0.031166667 0.96363722 0.01612883 FALSE TRUE
MSTRG.25879.6 ENSG00000164362 HEK293_OSMI2_6hA HEK293_TMG_6hB TERT protein_coding   3.216047 4.403447 1.943279 0.376825 0.2827244 -1.176008 0.1888918 0.3028022 0.0000000 0.08556627 0.00000000 -4.96717878 0.05448750 0.06740000 0.0000000 -0.067400000 0.01612883 0.01612883 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000164362 E001 0.000000       5 1253147 1253166 20 -      
ENSG00000164362 E002 23.961009 0.221074711 0.35890556 0.59492343 5 1253167 1253561 395 - 1.226 1.376 0.523
ENSG00000164362 E003 16.678674 0.140696459 0.24328447 0.48032993 5 1253562 1253675 114 - 1.028 1.240 0.760
ENSG00000164362 E004 17.762926 0.072484967 0.11981228 0.31555909 5 1253676 1253727 52 - 1.029 1.271 0.867
ENSG00000164362 E005 21.882316 0.104455355 0.09327067 0.26981987 5 1253728 1253831 104 - 1.088 1.360 0.965
ENSG00000164362 E006 22.271115 0.002339382 0.01006942 0.05846267 5 1254368 1254505 138 - 1.112 1.369 0.907
ENSG00000164362 E007 4.590644 0.046761877 0.09245290 0.26829967 5 1254582 1254606 25 - 0.420 0.775 1.605
ENSG00000164362 E008 4.371154 0.032796220 0.02638141 0.11641945 5 1254607 1254616 10 - 0.319 0.774 2.190
ENSG00000164362 E009 6.884060 0.011100753 0.19196853 0.41934870 5 1254617 1254664 48 - 0.681 0.897 0.862
ENSG00000164362 E010 2.665691 0.082081128 0.54493048 0.73260303 5 1254665 1254667 3 - 0.418 0.548 0.646
ENSG00000164362 E011 18.307169 0.176626389 0.40449032 0.63187992 5 1255287 1255411 125 - 1.132 1.262 0.460
ENSG00000164362 E012 12.228345 0.003458708 0.77430072 0.88133346 5 1258598 1258659 62 - 1.032 1.090 0.209
ENSG00000164362 E013 17.704046 0.002460056 0.39191538 0.62195124 5 1260474 1260600 127 - 1.251 1.203 -0.172
ENSG00000164362 E014 7.556467 0.005013364 0.40093545 0.62904955 5 1264248 1264403 156 - 0.935 0.853 -0.311
ENSG00000164362 E015 19.232985 0.013914287 0.38102475 0.61305500 5 1264404 1264592 189 - 1.301 1.242 -0.206
ENSG00000164362 E016 13.020372 0.037297735 0.33530546 0.57386174 5 1266464 1266535 72 - 1.164 1.083 -0.292
ENSG00000164362 E017 16.728734 0.004173449 0.01440970 0.07591904 5 1268520 1268633 114 - 1.335 1.151 -0.650
ENSG00000164362 E018 0.000000       5 1269715 1269782 68 -      
ENSG00000164362 E019 3.443166 0.008471875 0.23244890 0.46800918 5 1271119 1271204 86 - 0.728 0.565 -0.701
ENSG00000164362 E020 4.194379 0.005983183 0.05450489 0.19024899 5 1272185 1272280 96 - 0.844 0.588 -1.057
ENSG00000164362 E021 15.954080 0.014385157 0.18656547 0.41252040 5 1278641 1278760 120 - 1.252 1.151 -0.358
ENSG00000164362 E022 7.592002 0.005945659 0.45196492 0.66710852 5 1278761 1278796 36 - 0.935 0.865 -0.265
ENSG00000164362 E023 14.122346 0.005024621 0.58452582 0.76002364 5 1279291 1279470 180 - 1.148 1.122 -0.094
ENSG00000164362 E024 18.964802 0.073072113 0.36824883 0.60259366 5 1280158 1280338 181 - 1.329 1.214 -0.404
ENSG00000164362 E025 19.654601 0.003828333 0.19051808 0.41759435 5 1282429 1282624 196 - 1.325 1.241 -0.291
ENSG00000164362 E026 1.171344 0.015092525 0.82270092   5 1282625 1283010 386 - 0.319 0.292 -0.180
ENSG00000164362 E027 7.568252 0.003759294 0.10388405 0.28865783 5 1286165 1287086 922 - 1.010 0.841 -0.639
ENSG00000164362 E028 6.390563 0.012736003 0.19509493 0.42349369 5 1292964 1293312 349 - 0.935 0.788 -0.566
ENSG00000164362 E029 36.779857 0.035293559 0.88377629 0.94323744 5 1293313 1294666 1354 - 1.516 1.525 0.031
ENSG00000164362 E030 3.002244 0.219543159 0.84932529 0.92455121 5 1294771 1295068 298 - 0.504 0.559 0.256