ENSG00000164253

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296679 ENSG00000164253 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR41 protein_coding protein_coding 28.30619 9.085843 41.8211 1.567147 3.195111 2.201297 7.6459314 2.649109 10.562048 0.6118181 0.579327 1.9912402 0.28744583 0.2851333 0.25450000 -0.03063333 8.929953e-01 5.085273e-07 FALSE TRUE
ENST00000511630 ENSG00000164253 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR41 protein_coding protein_coding 28.30619 9.085843 41.8211 1.567147 3.195111 2.201297 1.6083554 0.000000 2.738342 0.0000000 1.386737 8.1024179 0.04074583 0.0000000 0.06306667 0.06306667 4.744042e-01 5.085273e-07 FALSE FALSE
ENST00000515253 ENSG00000164253 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR41 protein_coding protein_coding 28.30619 9.085843 41.8211 1.567147 3.195111 2.201297 7.2643755 2.649623 11.862258 0.5709453 0.411083 2.1583007 0.26512500 0.2866667 0.28586667 -0.00080000 1.000000e+00 5.085273e-07 FALSE TRUE
ENST00000515321 ENSG00000164253 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR41 protein_coding processed_transcript 28.30619 9.085843 41.8211 1.567147 3.195111 2.201297 2.4523463 0.000000 5.209225 0.0000000 1.902518 9.0276918 0.06182917 0.0000000 0.11976667 0.11976667 5.085273e-07 5.085273e-07 FALSE TRUE
MSTRG.26444.13 ENSG00000164253 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR41 protein_coding   28.30619 9.085843 41.8211 1.567147 3.195111 2.201297 0.8497907 0.000000 2.446786 0.0000000 1.651368 7.9406286 0.02359583 0.0000000 0.05370000 0.05370000 5.038615e-01 5.085273e-07 FALSE TRUE
MSTRG.26444.4 ENSG00000164253 HEK293_OSMI2_6hA HEK293_TMG_6hB WDR41 protein_coding   28.30619 9.085843 41.8211 1.567147 3.195111 2.201297 5.2345028 2.826023 4.761695 0.6367680 2.404338 0.7506327 0.20586667 0.3071000 0.12330000 -0.18380000 7.410544e-01 5.085273e-07 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000164253 E001 0.8214337 0.0176255888 0.2102979939   5 77425970 77426009 40 - 0.282 0.000 -11.675
ENSG00000164253 E002 0.9523018 0.0160734631 0.6680963608   5 77426010 77426051 42 - 0.282 0.196 -0.678
ENSG00000164253 E003 1.3802058 0.0127455572 0.3289481161   5 77426052 77426064 13 - 0.391 0.196 -1.354
ENSG00000164253 E004 2.5817374 0.0090691956 0.6090221242 0.77623810 5 77426065 77426124 60 - 0.528 0.433 -0.470
ENSG00000164253 E005 2.5899196 0.0090011438 0.9358297033 0.97010437 5 77426125 77426191 67 - 0.504 0.516 0.062
ENSG00000164253 E006 0.1614157 0.0352592188 1.0000000000   5 77426652 77426653 2 - 0.073 0.000 -9.337
ENSG00000164253 E007 2.5699548 0.3591498139 0.4965167173 0.69857710 5 77426654 77426943 290 - 0.475 0.592 0.550
ENSG00000164253 E008 1.9841020 0.1706361313 0.6114658265 0.77787570 5 77426944 77427034 91 - 0.418 0.513 0.478
ENSG00000164253 E009 117.2759711 0.0006214216 0.0031472937 0.02428767 5 77430933 77432243 1311 - 2.037 1.917 -0.403
ENSG00000164253 E010 183.6028619 0.0003849076 0.4815488078 0.68813058 5 77432244 77432812 569 - 2.198 2.218 0.069
ENSG00000164253 E011 90.1777563 0.0014961501 0.5703317076 0.75048631 5 77432813 77432892 80 - 1.889 1.911 0.076
ENSG00000164253 E012 97.9226792 0.0005638712 0.2141191169 0.44650897 5 77432893 77432977 85 - 1.943 1.889 -0.182
ENSG00000164253 E013 112.0068250 0.0003925608 0.6373013576 0.79524177 5 77432978 77433084 107 - 1.994 1.976 -0.063
ENSG00000164253 E014 156.6409755 0.0004027871 0.5903293719 0.76395431 5 77433085 77433287 203 - 2.133 2.150 0.059
ENSG00000164253 E015 144.4586272 0.0003198423 0.0614195781 0.20596132 5 77436261 77436359 99 - 2.085 2.147 0.206
ENSG00000164253 E016 98.8600977 0.0027371510 0.4904529630 0.69431060 5 77436360 77436378 19 - 1.929 1.957 0.094
ENSG00000164253 E017 81.3100144 0.0007840459 0.7156401809 0.84532352 5 77436379 77436394 16 - 1.850 1.866 0.053
ENSG00000164253 E018 123.1237741 0.0003449252 0.1755918771 0.39792281 5 77437336 77437406 71 - 2.019 2.067 0.163
ENSG00000164253 E019 87.2393768 0.0004580196 0.4478382965 0.66410424 5 77437407 77437424 18 - 1.875 1.908 0.109
ENSG00000164253 E020 101.9250512 0.0035772303 0.6979707293 0.83423526 5 77438240 77438257 18 - 1.945 1.957 0.043
ENSG00000164253 E021 154.8617432 0.0003733580 0.9956562243 0.99942525 5 77438258 77438361 104 - 2.128 2.127 -0.003
ENSG00000164253 E022 68.4496772 0.0083112416 0.8173345914 0.90656957 5 77440813 77440816 4 - 1.782 1.757 -0.085
ENSG00000164253 E023 144.9770312 0.0003037983 0.2533366841 0.49155531 5 77440817 77440930 114 - 2.092 2.130 0.127
ENSG00000164253 E024 105.4839319 0.0005375174 0.3641595609 0.59914377 5 77440931 77440997 67 - 1.959 1.996 0.122
ENSG00000164253 E025 55.5875862 0.0009348881 0.7387658977 0.85968292 5 77449760 77449764 5 - 1.690 1.709 0.064
ENSG00000164253 E026 87.6183036 0.0018827388 0.3835463603 0.61520074 5 77449765 77449803 39 - 1.878 1.921 0.143
ENSG00000164253 E027 70.9762446 0.0007000578 0.5927012017 0.76541445 5 77449804 77449814 11 - 1.793 1.819 0.089
ENSG00000164253 E028 76.5634214 0.0006715164 0.6977926167 0.83409282 5 77449815 77449830 16 - 1.826 1.845 0.063
ENSG00000164253 E029 82.0122563 0.0006401417 0.4585072826 0.67214304 5 77449831 77449860 30 - 1.851 1.885 0.114
ENSG00000164253 E030 69.5666539 0.0020032997 0.9349836887 0.96970090 5 77449861 77449870 10 - 1.786 1.791 0.019
ENSG00000164253 E031 74.7934468 0.0067800730 0.3803949677 0.61250630 5 77451291 77451323 33 - 1.803 1.856 0.178
ENSG00000164253 E032 66.2224270 0.0035254017 0.2142013060 0.44660771 5 77451324 77451346 23 - 1.746 1.815 0.234
ENSG00000164253 E033 52.9546807 0.0023658622 0.7609898339 0.87316448 5 77451347 77451353 7 - 1.662 1.679 0.059
ENSG00000164253 E034 19.5842953 0.0017126989 0.0120339519 0.06658983 5 77451354 77452873 1520 - 1.300 1.052 -0.884
ENSG00000164253 E035 2.1890155 0.0113410385 0.1001673142 0.28210139 5 77453802 77453816 15 - 0.527 0.196 -2.052
ENSG00000164253 E036 111.3417252 0.0015344847 0.6019165453 0.77143827 5 77453817 77453865 49 - 1.983 2.005 0.072
ENSG00000164253 E037 90.6288632 0.0035709014 0.4149838854 0.63980125 5 77453866 77453878 13 - 1.911 1.867 -0.146
ENSG00000164253 E038 89.1650112 0.0024855823 0.4521375533 0.66727224 5 77453879 77453888 10 - 1.902 1.865 -0.125
ENSG00000164253 E039 93.4229085 0.0011265656 0.4904669222 0.69432457 5 77453889 77453910 22 - 1.920 1.889 -0.105
ENSG00000164253 E040 78.3715432 0.0019086462 0.3841780556 0.61574766 5 77453911 77453928 18 - 1.846 1.800 -0.154
ENSG00000164253 E041 1.0949365 0.0140069872 0.5278417062   5 77458859 77459049 191 - 0.321 0.196 -0.940
ENSG00000164253 E042 0.8214337 0.0176255888 0.2102979939   5 77459050 77459061 12 - 0.282 0.000 -11.660
ENSG00000164253 E043 115.7833202 0.0004880668 0.0327149196 0.13525950 5 77459062 77459124 63 - 2.023 1.938 -0.288
ENSG00000164253 E044 0.3393995 0.0247200351 0.8067347267   5 77463093 77463094 2 - 0.135 0.000 -10.338
ENSG00000164253 E045 77.4897441 0.0004957176 0.1677233544 0.38757512 5 77463095 77463105 11 - 1.847 1.781 -0.223
ENSG00000164253 E046 87.5017080 0.0004791133 0.4164875282 0.64102671 5 77463106 77463123 18 - 1.893 1.856 -0.124
ENSG00000164253 E047 164.3353983 0.0010880700 0.0441068509 0.16537927 5 77463124 77463226 103 - 2.174 2.102 -0.244
ENSG00000164253 E048 116.4335086 0.0013364672 0.0510847781 0.18228631 5 77464761 77464809 49 - 2.029 1.945 -0.279
ENSG00000164253 E049 0.0000000       5 77480081 77480189 109 -      
ENSG00000164253 E050 0.9873907 0.2317009435 0.0698055829   5 77485413 77485541 129 - 0.136 0.517 2.636
ENSG00000164253 E051 130.9747036 0.0046234550 0.2793761331 0.51949197 5 77489457 77489550 94 - 2.073 2.020 -0.178
ENSG00000164253 E052 62.2975574 0.0079706347 0.6077425466 0.77536370 5 77489551 77489557 7 - 1.752 1.712 -0.133
ENSG00000164253 E053 65.6501957 0.0031480315 0.7540848178 0.86919281 5 77489558 77489572 15 - 1.770 1.750 -0.067
ENSG00000164253 E054 0.3453689 0.0307391759 0.3978599881   5 77491193 77491285 93 - 0.073 0.196 1.651
ENSG00000164253 E055 1.2966026 0.1315714704 0.0008364420   5 77491812 77492158 347 - 0.072 0.700 4.467
ENSG00000164253 E056 0.9750270 0.0156870949 0.6742297009   5 77492159 77492169 11 - 0.281 0.196 -0.675
ENSG00000164253 E057 70.9045985 0.0044517825 0.7692166135 0.87817759 5 77492170 77492195 26 - 1.794 1.810 0.055
ENSG00000164253 E058 68.8458040 0.0006615219 0.0541829819 0.18951168 5 77492196 77492252 57 - 1.757 1.849 0.310
ENSG00000164253 E059 61.7272518 0.0006101223 0.0005215931 0.00586915 5 77492253 77492531 279 - 1.687 1.856 0.572
ENSG00000164253 E060 0.0000000       5 77499327 77499636 310 -      
ENSG00000164253 E061 0.0000000       5 77540458 77540536 79 -      
ENSG00000164253 E062 0.0000000       5 77620479 77620611 133 -