ENSG00000164190

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000282516 ENSG00000164190 HEK293_OSMI2_6hA HEK293_TMG_6hB NIPBL protein_coding protein_coding 8.891819 4.451148 16.34107 1.17659 0.9667875 1.873898 0.4761208 0.0000000 0.8467848 0.0000000 0.56357022 6.4208609 0.0370750 0.00000000 0.05233333 0.05233333 0.5499707717 0.0004886569 FALSE TRUE
ENST00000448238 ENSG00000164190 HEK293_OSMI2_6hA HEK293_TMG_6hB NIPBL protein_coding protein_coding 8.891819 4.451148 16.34107 1.17659 0.9667875 1.873898 4.8695039 1.8746598 10.3324529 0.4279227 0.65141882 2.4562023 0.4630750 0.43886667 0.63403333 0.19516667 0.1274906634 0.0004886569 FALSE TRUE
ENST00000513819 ENSG00000164190 HEK293_OSMI2_6hA HEK293_TMG_6hB NIPBL protein_coding protein_coding 8.891819 4.451148 16.34107 1.17659 0.9667875 1.873898 0.8657832 0.2452720 1.2156705 0.2452720 0.62283121 2.2634638 0.1262458 0.04336667 0.07066667 0.02730000 0.8154755509 0.0004886569 FALSE FALSE
ENST00000514335 ENSG00000164190 HEK293_OSMI2_6hA HEK293_TMG_6hB NIPBL protein_coding retained_intron 8.891819 4.451148 16.34107 1.17659 0.9667875 1.873898 0.4134067 0.4589333 0.1732808 0.1904431 0.09001921 -1.3553266 0.0929000 0.10026667 0.01126667 -0.08900000 0.0755287955 0.0004886569 FALSE TRUE
MSTRG.26082.2 ENSG00000164190 HEK293_OSMI2_6hA HEK293_TMG_6hB NIPBL protein_coding   8.891819 4.451148 16.34107 1.17659 0.9667875 1.873898 0.4048425 0.0000000 0.8633869 0.0000000 0.20488677 6.4485491 0.0306125 0.00000000 0.05373333 0.05373333 0.0017014663 0.0004886569 FALSE TRUE
MSTRG.26082.6 ENSG00000164190 HEK293_OSMI2_6hA HEK293_TMG_6hB NIPBL protein_coding   8.891819 4.451148 16.34107 1.17659 0.9667875 1.873898 1.8000187 1.8370066 2.8151389 0.5220474 0.32237218 0.6131327 0.2436833 0.41116667 0.17226667 -0.23890000 0.0004886569 0.0004886569 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000164190 E001 0.0000000       5 36876769 36876789 21 +      
ENSG00000164190 E002 0.3206185 0.0274424043 8.040872e-01   5 36876790 36876840 51 + 0.136 0.000 -8.650
ENSG00000164190 E003 2.0685585 0.0155414549 1.442696e-02 7.598905e-02 5 36876841 36876857 17 + 0.531 0.000 -14.105
ENSG00000164190 E004 21.5575763 0.0017676926 1.235750e-03 1.168869e-02 5 36876858 36877130 273 + 1.354 1.048 -1.087
ENSG00000164190 E005 16.4025329 0.0064146969 1.861748e-02 9.111553e-02 5 36877131 36877178 48 + 1.232 0.976 -0.927
ENSG00000164190 E006 37.3481016 0.0350377895 9.109950e-03 5.431397e-02 5 36953618 36953760 143 + 1.585 1.281 -1.047
ENSG00000164190 E007 0.0000000       5 36954968 36955010 43 +      
ENSG00000164190 E008 47.3882493 0.0101951183 2.762656e-05 5.019928e-04 5 36955472 36955637 166 + 1.690 1.347 -1.178
ENSG00000164190 E009 37.9473865 0.0023768212 1.037136e-05 2.164818e-04 5 36958104 36958231 128 + 1.593 1.254 -1.173
ENSG00000164190 E010 17.4592444 0.0020262620 4.228241e-05 7.212984e-04 5 36961484 36961505 22 + 1.284 0.823 -1.692
ENSG00000164190 E011 28.1688592 0.0047517379 7.670218e-02 2.381647e-01 5 36961506 36961583 78 + 1.439 1.293 -0.509
ENSG00000164190 E012 49.0553371 0.0020099236 1.678374e-03 1.486991e-02 5 36962123 36962274 152 + 1.683 1.482 -0.684
ENSG00000164190 E013 47.5812688 0.0023058535 7.784020e-06 1.688257e-04 5 36970876 36971036 161 + 1.688 1.382 -1.045
ENSG00000164190 E014 43.5872459 0.0258040280 4.518944e-05 7.634506e-04 5 36971945 36972041 97 + 1.668 1.231 -1.507
ENSG00000164190 E015 122.5888125 0.0340534686 9.646105e-07 2.753001e-05 5 36975776 36976402 627 + 2.112 1.633 -1.616
ENSG00000164190 E016 318.6272510 0.0002280532 4.191768e-31 3.707597e-28 5 36984676 36986301 1626 + 2.501 2.205 -0.988
ENSG00000164190 E017 0.0000000       5 36995150 36995621 472 +      
ENSG00000164190 E018 65.5396294 0.0222154739 1.427127e-01 3.514942e-01 5 36995622 36995749 128 + 1.797 1.645 -0.512
ENSG00000164190 E019 40.8524520 0.0011917664 5.401811e-04 6.038387e-03 5 36995750 36995804 55 + 1.611 1.373 -0.818
ENSG00000164190 E020 0.4514866 0.0217681645 7.328623e-01   5 36996472 36997002 531 + 0.136 0.194 0.613
ENSG00000164190 E021 73.1392931 0.0006381364 4.698961e-03 3.299923e-02 5 37000373 37000570 198 + 1.839 1.700 -0.470
ENSG00000164190 E022 45.1741224 0.0008882738 9.328496e-03 5.521402e-02 5 37000817 37000888 72 + 1.643 1.482 -0.549
ENSG00000164190 E023 52.5895430 0.0006871978 1.292964e-01 3.306454e-01 5 37000989 37001078 90 + 1.690 1.608 -0.279
ENSG00000164190 E024 57.6103894 0.0054669134 8.611402e-04 8.780631e-03 5 37002662 37002765 104 + 1.754 1.533 -0.752
ENSG00000164190 E025 52.6152412 0.0007354202 3.938189e-04 4.670356e-03 5 37003261 37003347 87 + 1.715 1.506 -0.713
ENSG00000164190 E026 97.2124994 0.0023084954 1.585269e-02 8.125531e-02 5 37006357 37006588 232 + 1.961 1.849 -0.376
ENSG00000164190 E027 79.0293221 0.0005260046 2.576854e-01 4.964424e-01 5 37007323 37007474 152 + 1.855 1.808 -0.160
ENSG00000164190 E028 56.2835832 0.0042796793 1.965748e-01 4.252675e-01 5 37008008 37008088 81 + 1.715 1.636 -0.268
ENSG00000164190 E029 57.4150001 0.0099270314 4.723753e-01 6.818257e-01 5 37008623 37008723 101 + 1.718 1.664 -0.183
ENSG00000164190 E030 70.9554169 0.0115361534 5.765214e-01 7.547882e-01 5 37010087 37010225 139 + 1.807 1.757 -0.169
ENSG00000164190 E031 60.3712360 0.0013573649 9.997543e-03 5.815224e-02 5 37014683 37014765 83 + 1.758 1.614 -0.489
ENSG00000164190 E032 67.8589509 0.0014553907 3.648893e-01 5.998354e-01 5 37016038 37016170 133 + 1.787 1.742 -0.154
ENSG00000164190 E033 65.3582399 0.0007079855 9.795489e-01 9.915888e-01 5 37017019 37017162 144 + 1.760 1.764 0.011
ENSG00000164190 E034 70.3096897 0.0005566783 2.607393e-01 4.997507e-01 5 37019311 37019400 90 + 1.805 1.755 -0.169
ENSG00000164190 E035 105.3569356 0.0004809657 1.386247e-01 3.454287e-01 5 37020459 37020673 215 + 1.977 1.921 -0.187
ENSG00000164190 E036 67.4826418 0.0044838804 8.624085e-01 9.316650e-01 5 37020775 37020877 103 + 1.775 1.767 -0.028
ENSG00000164190 E037 80.7220082 0.0007424810 7.005557e-01 8.359721e-01 5 37022051 37022149 99 + 1.846 1.868 0.074
ENSG00000164190 E038 87.0715342 0.0006587824 5.405526e-01 7.293889e-01 5 37022244 37022390 147 + 1.877 1.909 0.108
ENSG00000164190 E039 81.5834440 0.0005675060 6.355279e-01 7.939271e-01 5 37024585 37024719 135 + 1.852 1.878 0.088
ENSG00000164190 E040 66.9091972 0.0005810472 2.628137e-01 5.020676e-01 5 37026229 37026327 99 + 1.756 1.815 0.200
ENSG00000164190 E041 49.6013280 0.0010344347 1.127609e-01 3.037610e-01 5 37027359 37027412 54 + 1.617 1.710 0.315
ENSG00000164190 E042 61.0766605 0.0006371337 1.533660e-01 3.671319e-01 5 37036379 37036487 109 + 1.712 1.788 0.259
ENSG00000164190 E043 84.3146249 0.0005870936 1.231469e-01 3.207198e-01 5 37038602 37038738 137 + 1.853 1.924 0.241
ENSG00000164190 E044 90.4576784 0.0004643554 2.088738e-02 9.898031e-02 5 37044347 37044487 141 + 1.876 1.976 0.338
ENSG00000164190 E045 73.3089741 0.0005620191 2.582437e-02 1.147425e-01 5 37044636 37044729 94 + 1.783 1.891 0.361
ENSG00000164190 E046 84.9681455 0.0005295582 2.181015e-01 4.511463e-01 5 37045443 37045597 155 + 1.863 1.921 0.196
ENSG00000164190 E047 49.8239120 0.0007085960 3.865700e-02 1.512672e-01 5 37046109 37046199 91 + 1.615 1.733 0.401
ENSG00000164190 E048 79.8870786 0.0005099584 3.585286e-02 1.438312e-01 5 37048502 37048675 174 + 1.824 1.921 0.328
ENSG00000164190 E049 99.1018624 0.0019638138 8.302287e-05 1.281104e-03 5 37049111 37049301 191 + 1.892 2.069 0.596
ENSG00000164190 E050 2.1334597 0.0720239069 4.590895e-01 6.725361e-01 5 37050943 37051778 836 + 0.483 0.328 -0.851
ENSG00000164190 E051 74.2923927 0.0007345377 1.086501e-06 3.053332e-05 5 37051779 37051886 108 + 1.755 1.976 0.745
ENSG00000164190 E052 113.7281687 0.0010607894 3.896175e-08 1.594746e-06 5 37052366 37052566 201 + 1.938 2.151 0.715
ENSG00000164190 E053 109.1375717 0.0004970685 4.171551e-08 1.693987e-06 5 37057186 37057332 147 + 1.921 2.128 0.692
ENSG00000164190 E054 53.5781638 0.0006740386 2.322008e-04 3.025398e-03 5 37058891 37058902 12 + 1.620 1.815 0.660
ENSG00000164190 E055 153.0100546 0.0004259865 3.083207e-12 2.916989e-10 5 37058903 37059165 263 + 2.060 2.281 0.741
ENSG00000164190 E056 119.8158465 0.0118161894 3.958539e-04 4.690232e-03 5 37060844 37061018 175 + 1.950 2.177 0.762
ENSG00000164190 E057 126.2407360 0.0065882428 8.407714e-05 1.293670e-03 5 37063790 37063978 189 + 1.983 2.187 0.683
ENSG00000164190 E058 24.0978381 0.0023227706 9.172063e-03 5.458655e-02 5 37063979 37064019 41 + 1.276 1.482 0.714
ENSG00000164190 E059 18.5380034 0.0483748995 7.493613e-04 7.854996e-03 5 37064020 37064190 171 + 1.053 1.534 1.689
ENSG00000164190 E060 145.2722751 0.0183293952 1.324251e-05 2.677561e-04 5 37064527 37066413 1887 + 2.007 2.309 1.009