ENSG00000164187

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296603 ENSG00000164187 HEK293_OSMI2_6hA HEK293_TMG_6hB LMBRD2 protein_coding protein_coding 3.199959 0.4598541 6.1502 0.07916924 0.06722683 3.712692 2.2887175 0.3381300 4.512062 0.0247472 0.2169784 3.699283 0.7139458 0.7742667 0.7338333 -0.04043333 1.000000000 0.001040156 FALSE TRUE
ENST00000503535 ENSG00000164187 HEK293_OSMI2_6hA HEK293_TMG_6hB LMBRD2 protein_coding retained_intron 3.199959 0.4598541 6.1502 0.07916924 0.06722683 3.712692 0.1016557 0.1217241 0.000000 0.0632977 0.0000000 -3.719447 0.1326583 0.2257333 0.0000000 -0.22573333 0.001040156 0.001040156   FALSE
MSTRG.26064.2 ENSG00000164187 HEK293_OSMI2_6hA HEK293_TMG_6hB LMBRD2 protein_coding   3.199959 0.4598541 6.1502 0.07916924 0.06722683 3.712692 0.6856118 0.0000000 1.638138 0.0000000 0.2287973 7.364693 0.1272083 0.0000000 0.2661667 0.26616667 0.001633529 0.001040156 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000164187 E001 287.3660863 0.009347100 0.6334314529 0.79257338 5 36098407 36103848 5442 - 2.184 2.212 0.092
ENSG00000164187 E002 39.5267490 0.001331594 0.6646158716 0.81277279 5 36103849 36104106 258 - 1.340 1.395 0.189
ENSG00000164187 E003 28.5513044 0.021998387 0.9650991778 0.98447340 5 36105068 36105197 130 - 1.210 1.226 0.055
ENSG00000164187 E004 0.3393995 0.024885221 1.0000000000   5 36108522 36108533 12 - 0.073 0.000 -8.196
ENSG00000164187 E005 22.9802882 0.006364855 0.4087909649 0.63508803 5 36108534 36108639 106 - 1.114 1.227 0.404
ENSG00000164187 E006 20.3213810 0.001917050 0.3203113464 0.55998923 5 36109945 36109991 47 - 1.062 1.197 0.484
ENSG00000164187 E007 25.5891596 0.001470447 0.4568241454 0.67088602 5 36111155 36111258 104 - 1.158 1.256 0.346
ENSG00000164187 E008 16.1805043 0.029004415 0.3325879696 0.57131240 5 36114424 36114484 61 - 0.991 0.823 -0.635
ENSG00000164187 E009 13.6874224 0.017287557 0.5579126382 0.74178443 5 36114485 36114521 37 - 0.919 0.825 -0.361
ENSG00000164187 E010 21.4508344 0.030568515 0.7398681000 0.86033539 5 36115015 36115120 106 - 1.094 1.049 -0.165
ENSG00000164187 E011 22.1751268 0.002088208 0.4681217441 0.67880151 5 36116460 36116593 134 - 1.096 1.197 0.362
ENSG00000164187 E012 26.9994126 0.001692215 0.9913361360 0.99742632 5 36117735 36117916 182 - 1.183 1.197 0.052
ENSG00000164187 E013 25.5662736 0.008210872 0.0443397149 0.16592290 5 36122280 36122463 184 - 1.183 0.893 -1.065
ENSG00000164187 E014 24.9487652 0.017875559 0.3917273757 0.62182139 5 36122848 36122961 114 - 1.161 1.050 -0.403
ENSG00000164187 E015 22.8328156 0.004345206 0.0927092275 0.26880009 5 36124191 36124265 75 - 1.130 0.892 -0.876
ENSG00000164187 E016 40.2878347 0.016209619 0.0066809496 0.04310710 5 36136309 36136519 211 - 1.368 1.003 -1.300
ENSG00000164187 E017 34.5623822 0.001364251 0.0056257865 0.03786564 5 36137274 36137441 168 - 1.303 0.952 -1.265
ENSG00000164187 E018 0.6536007 0.021307567 0.0009002926   5 36141041 36141106 66 - 0.038 0.644 5.213
ENSG00000164187 E019 24.2691254 0.001417181 0.5889503753 0.76294935 5 36141107 36141202 96 - 1.147 1.092 -0.199
ENSG00000164187 E020 22.6279458 0.001896653 0.0383679454 0.15053854 5 36142502 36142599 98 - 1.089 1.331 0.855
ENSG00000164187 E021 0.1308682 0.032649190 0.0203615748   5 36142600 36142757 158 - 0.000 0.329 13.752
ENSG00000164187 E022 26.2397980 0.001772202 0.0544564687 0.19015423 5 36143176 36143406 231 - 1.161 1.374 0.750
ENSG00000164187 E023 1.6441053 0.330201112 0.6358193811 0.79415110 5 36151088 36151555 468 - 0.296 0.000 -11.295
ENSG00000164187 E024 16.4632025 0.904978803 0.4311440587 0.65202217 5 36151556 36151887 332 - 0.955 1.283 1.180