ENSG00000164164

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000447906 ENSG00000164164 HEK293_OSMI2_6hA HEK293_TMG_6hB OTUD4 protein_coding protein_coding 11.8205 5.999294 19.84369 1.366044 0.7296935 1.72414 2.562479 0.00000000 2.529469 0.00000000 0.9460112 7.988383 0.1605750 0.0000000 0.12510000 0.12510000 1.840362e-04 4.309966e-07 FALSE TRUE
ENST00000454497 ENSG00000164164 HEK293_OSMI2_6hA HEK293_TMG_6hB OTUD4 protein_coding protein_coding 11.8205 5.999294 19.84369 1.366044 0.7296935 1.72414 6.169542 4.16369349 11.417796 0.95485660 0.9269895 1.453151 0.5913167 0.6947333 0.57370000 -0.12103333 2.995297e-01 4.309966e-07 FALSE TRUE
ENST00000509517 ENSG00000164164 HEK293_OSMI2_6hA HEK293_TMG_6hB OTUD4 protein_coding retained_intron 11.8205 5.999294 19.84369 1.366044 0.7296935 1.72414 1.002273 0.03066812 1.952867 0.03066812 0.1412651 5.592920 0.0602125 0.0042000 0.09816667 0.09396667 4.309966e-07 4.309966e-07 FALSE TRUE
MSTRG.25581.2 ENSG00000164164 HEK293_OSMI2_6hA HEK293_TMG_6hB OTUD4 protein_coding   11.8205 5.999294 19.84369 1.366044 0.7296935 1.72414 1.582084 1.62017087 3.066786 0.46855060 0.9482900 0.916401 0.1386250 0.2653333 0.15840000 -0.10693333 5.286287e-01 4.309966e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000164164 E001 0.3559677 1.004005953 0.8073378230   4 145110838 145111128 291 - 0.136 0.000 -23.657
ENSG00000164164 E002 0.0000000       4 145127946 145128124 179 -      
ENSG00000164164 E003 0.4950181 0.021768165 0.1968165905   4 145133583 145133648 66 - 0.070 0.339 2.753
ENSG00000164164 E004 0.3641499 0.027843274 0.5304244980   4 145133649 145133649 1 - 0.070 0.202 1.756
ENSG00000164164 E005 1075.6096780 2.047245168 0.4269773764 0.648707507 4 145133650 145138650 5001 - 2.845 3.205 1.196
ENSG00000164164 E006 35.8996699 0.129306598 0.3258484613 0.565091276 4 145139951 145139991 41 - 1.417 1.693 0.945
ENSG00000164164 E007 123.0827152 0.005521993 0.2650950749 0.504418496 4 145141379 145141639 261 - 1.996 2.109 0.379
ENSG00000164164 E008 104.9146593 0.023568059 0.2299613703 0.465124871 4 145142196 145142334 139 - 1.934 2.009 0.250
ENSG00000164164 E009 78.1710659 0.014133980 0.3932138706 0.622936314 4 145143365 145143445 81 - 1.799 1.906 0.361
ENSG00000164164 E010 73.0783272 0.017881206 0.1347418433 0.339293072 4 145143946 145144001 56 - 1.786 1.845 0.197
ENSG00000164164 E011 100.2860319 0.035475340 0.2445017588 0.481663497 4 145144311 145144434 124 - 1.912 1.996 0.281
ENSG00000164164 E012 7.9852417 0.071778851 0.0006628744 0.007122513 4 145146094 145146266 173 - 0.968 0.441 -2.234
ENSG00000164164 E013 82.6685580 0.040963413 0.0622051786 0.207744734 4 145146267 145146373 107 - 1.849 1.852 0.007
ENSG00000164164 E014 62.7017763 0.034097006 0.0134670305 0.072248034 4 145146374 145146429 56 - 1.746 1.683 -0.213
ENSG00000164164 E015 100.7571793 0.033489146 0.0132261245 0.071358512 4 145150513 145150699 187 - 1.948 1.893 -0.187
ENSG00000164164 E016 69.6511744 0.045084901 0.0417979543 0.159403862 4 145150802 145150905 104 - 1.787 1.739 -0.164
ENSG00000164164 E017 71.1983739 0.038994766 0.0414676636 0.158550141 4 145152541 145152635 95 - 1.793 1.763 -0.101
ENSG00000164164 E018 59.7447641 0.028797643 0.0075013641 0.047033567 4 145155411 145155475 65 - 1.731 1.645 -0.293
ENSG00000164164 E019 66.9609487 0.040144634 0.0191930509 0.093130061 4 145155569 145155683 115 - 1.778 1.701 -0.261
ENSG00000164164 E020 23.4238533 0.001598783 0.0002885017 0.003613409 4 145155684 145155686 3 - 1.357 1.199 -0.557
ENSG00000164164 E021 1.4464624 0.013696863 0.6159794117 0.780995989 4 145155813 145155838 26 - 0.348 0.340 -0.051
ENSG00000164164 E022 42.4620980 0.038833971 0.0222230767 0.103348839 4 145155936 145155996 61 - 1.588 1.502 -0.293
ENSG00000164164 E023 6.0854013 0.073745175 0.8509172802 0.925554364 4 145159137 145159502 366 - 0.760 0.874 0.446
ENSG00000164164 E024 31.7671153 0.038914738 0.0267756109 0.117619615 4 145159503 145159519 17 - 1.466 1.384 -0.286
ENSG00000164164 E025 60.8629164 0.048191880 0.0639169117 0.211507438 4 145159520 145159635 116 - 1.731 1.689 -0.141
ENSG00000164164 E026 45.9498748 0.058421084 0.0750361630 0.234900205 4 145162640 145162721 82 - 1.616 1.554 -0.211
ENSG00000164164 E027 39.7285955 0.049586945 0.0518088156 0.184018561 4 145164154 145164226 73 - 1.555 1.487 -0.233
ENSG00000164164 E028 35.9130598 0.043834011 0.0619998774 0.207263881 4 145165151 145165191 41 - 1.510 1.450 -0.205
ENSG00000164164 E029 30.2121491 0.057173030 0.0527466704 0.186108699 4 145165192 145165197 6 - 1.444 1.349 -0.330
ENSG00000164164 E030 0.7908862 0.024023419 0.6194610716   4 145170769 145171317 549 - 0.231 0.202 -0.251
ENSG00000164164 E031 41.4565946 0.032516033 0.0113022821 0.063613541 4 145171670 145171720 51 - 1.579 1.477 -0.348
ENSG00000164164 E032 39.3884139 0.035550609 0.0092591052 0.054950890 4 145174661 145174744 84 - 1.560 1.443 -0.402
ENSG00000164164 E033 0.1426347 0.031396758 1.0000000000   4 145178128 145178155 28 - 0.070 0.000 -22.532
ENSG00000164164 E034 0.0000000       4 145178514 145178570 57 -      
ENSG00000164164 E035 0.1426347 0.031396758 1.0000000000   4 145179579 145179680 102 - 0.070 0.000 -22.532
ENSG00000164164 E036 58.7882802 0.062049438 0.4916537328 0.695095568 4 145179815 145180589 775 - 1.680 1.774 0.317