ENSG00000164134

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296543 ENSG00000164134 HEK293_OSMI2_6hA HEK293_TMG_6hB NAA15 protein_coding protein_coding 33.53547 6.558351 63.01468 1.52258 2.716436 3.262314 22.405488 6.0418978 40.335608 1.3611489 1.852747 2.736952 0.76016250 0.92693333 0.64013333 -0.286800000 1.084732e-07 3.631317e-26 FALSE TRUE
ENST00000398947 ENSG00000164134 HEK293_OSMI2_6hA HEK293_TMG_6hB NAA15 protein_coding protein_coding 33.53547 6.558351 63.01468 1.52258 2.716436 3.262314 1.480056 0.3726005 2.933216 0.1689742 0.307851 2.943483 0.07114583 0.04993333 0.04666667 -0.003266667 9.789460e-01 3.631317e-26 FALSE TRUE
ENST00000480277 ENSG00000164134 HEK293_OSMI2_6hA HEK293_TMG_6hB NAA15 protein_coding processed_transcript 33.53547 6.558351 63.01468 1.52258 2.716436 3.262314 9.296416 0.0000000 19.238826 0.0000000 1.245276 10.910555 0.15169167 0.00000000 0.30496667 0.304966667 3.631317e-26 3.631317e-26 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000164134 E001 78.5542688 1.4048082421 6.175820e-01 7.822109e-01 4 139301505 139301587 83 + 1.729 1.810 0.274
ENSG00000164134 E002 157.2034366 1.6063603562 5.921126e-01 7.650772e-01 4 139301588 139301831 244 + 2.020 2.134 0.382
ENSG00000164134 E003 0.0000000       4 139301984 139302181 198 +      
ENSG00000164134 E004 147.1761199 0.0356675478 8.880700e-01 9.456238e-01 4 139334174 139334258 85 + 2.007 2.029 0.072
ENSG00000164134 E005 113.3862565 0.0032917918 3.418077e-02 1.393380e-01 4 139336848 139336872 25 + 1.910 1.823 -0.293
ENSG00000164134 E006 198.5399193 0.0002359950 1.226207e-05 2.501959e-04 4 139336873 139336952 80 + 2.156 2.021 -0.451
ENSG00000164134 E007 324.2248807 0.0002037815 2.438301e-08 1.049099e-06 4 139340912 139341069 158 + 2.367 2.232 -0.450
ENSG00000164134 E008 1.1630461 0.3498245608 4.820525e-01   4 139341070 139341073 4 + 0.280 0.000 -10.983
ENSG00000164134 E009 261.7127092 0.0002223480 3.192804e-04 3.923951e-03 4 139342826 139342960 135 + 2.269 2.186 -0.278
ENSG00000164134 E010 238.8151033 0.0002773191 9.599934e-04 9.587119e-03 4 139344186 139344339 154 + 2.230 2.152 -0.262
ENSG00000164134 E011 199.7230223 0.0002765891 1.881385e-03 1.627457e-02 4 139349462 139349581 120 + 2.154 2.072 -0.273
ENSG00000164134 E012 162.6141718 0.0003766880 1.263513e-01 3.260154e-01 4 139351191 139351286 96 + 2.058 2.031 -0.091
ENSG00000164134 E013 116.0798542 0.0004541452 2.584139e-01 4.972198e-01 4 139351505 139351534 30 + 1.912 1.892 -0.066
ENSG00000164134 E014 177.9630159 0.0002516647 5.178304e-03 3.555698e-02 4 139351535 139351611 77 + 2.104 2.028 -0.253
ENSG00000164134 E015 0.5173834 0.0759016305 1.000000e+00   4 139351612 139351613 2 + 0.141 0.000 -9.736
ENSG00000164134 E016 188.9271529 0.0039233399 2.404724e-02 1.092239e-01 4 139354026 139354098 73 + 2.129 2.051 -0.262
ENSG00000164134 E017 0.1426347 0.0328419721 1.000000e+00   4 139356489 139356583 95 + 0.052 0.000 -8.141
ENSG00000164134 E018 278.3480432 0.0019450480 6.261590e-02 2.086453e-01 4 139357386 139357555 170 + 2.291 2.252 -0.130
ENSG00000164134 E019 279.3813056 0.0007422258 1.564647e-01 3.715435e-01 4 139359743 139359895 153 + 2.290 2.277 -0.043
ENSG00000164134 E020 288.8324340 0.0002809013 1.261602e-01 3.257549e-01 4 139360500 139360628 129 + 2.304 2.292 -0.039
ENSG00000164134 E021 408.9078001 0.0025384358 4.562142e-02 1.690858e-01 4 139361724 139361937 214 + 2.456 2.423 -0.111
ENSG00000164134 E022 369.8640412 0.0055998116 9.894864e-01 9.965104e-01 4 139370211 139370404 194 + 2.403 2.444 0.134
ENSG00000164134 E023 148.5054419 0.0003712354 3.529993e-02 1.423760e-01 4 139376365 139376376 12 + 2.000 2.118 0.394
ENSG00000164134 E024 245.1254792 0.0002978655 1.184208e-02 6.579822e-02 4 139376377 139376473 97 + 2.216 2.328 0.376
ENSG00000164134 E025 246.2499866 0.0007190821 8.963842e-02 2.631448e-01 4 139378756 139378854 99 + 2.219 2.309 0.303
ENSG00000164134 E026 3.2405226 0.0389274334 5.011506e-01 7.016113e-01 4 139378855 139379335 481 + 0.481 0.633 0.698
ENSG00000164134 E027 95.7928872 0.0004483191 3.349064e-01 5.734735e-01 4 139384832 139384834 3 + 1.815 1.897 0.276
ENSG00000164134 E028 89.7806139 0.0005826853 3.499584e-01 5.871978e-01 4 139384835 139384835 1 + 1.786 1.869 0.279
ENSG00000164134 E029 287.2509153 0.0002157756 1.608465e-01 3.780190e-01 4 139384836 139384978 143 + 2.288 2.364 0.252
ENSG00000164134 E030 200.7905563 0.0003632502 5.856564e-01 7.606993e-01 4 139386133 139386167 35 + 2.136 2.190 0.182
ENSG00000164134 E031 243.1851650 0.0024602418 4.344532e-01 6.545741e-01 4 139386168 139386230 63 + 2.216 2.284 0.225
ENSG00000164134 E032 0.5173834 0.0759016305 1.000000e+00   4 139386231 139386547 317 + 0.141 0.000 -9.736
ENSG00000164134 E033 1527.3906079 0.0060407831 7.931363e-04 8.225012e-03 4 139387884 139391384 3501 + 2.999 3.142 0.474
ENSG00000164134 E034 1.4020530 0.4488899056 1.822500e-01 4.069379e-01 4 139393591 139393722 132 + 0.219 0.551 1.967
ENSG00000164134 E035 0.3393995 0.0252072849 1.000000e+00   4 139404398 139404490 93 + 0.098 0.000 -9.144
ENSG00000164134 E036 1.4802661 0.5385901632 3.133935e-02 1.313234e-01 4 139417866 139420033 2168 + 0.172 0.760 3.289