ENSG00000164118

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296519 ENSG00000164118 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP44 protein_coding protein_coding 7.638168 1.909736 18.24319 0.3592021 0.3889995 3.249169 0.5521435 0.27215766 0.4341635 0.27215766 0.4341635 0.6545892 0.19549167 0.1616000 0.02383333 -0.13776667 0.89067560 0.03897167 FALSE TRUE
ENST00000503780 ENSG00000164118 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP44 protein_coding protein_coding 7.638168 1.909736 18.24319 0.3592021 0.3889995 3.249169 2.2585095 0.65206298 5.7278739 0.32604341 0.4540755 3.1154759 0.27917083 0.3519667 0.31406667 -0.03790000 1.00000000 0.03897167 FALSE TRUE
ENST00000505124 ENSG00000164118 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP44 protein_coding protein_coding 7.638168 1.909736 18.24319 0.3592021 0.3889995 3.249169 1.7903294 0.27450938 5.0438670 0.14247684 0.3287342 4.1508396 0.17279583 0.1293667 0.27690000 0.14753333 0.56415046 0.03897167 FALSE FALSE
ENST00000508483 ENSG00000164118 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP44 protein_coding retained_intron 7.638168 1.909736 18.24319 0.3592021 0.3889995 3.249169 0.8178128 0.31500886 1.9677467 0.19126763 0.0694381 2.6053068 0.10237083 0.1405000 0.10796667 -0.03253333 0.97152498 0.03897167 FALSE TRUE
MSTRG.25742.10 ENSG00000164118 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP44 protein_coding   7.638168 1.909736 18.24319 0.3592021 0.3889995 3.249169 0.3656203 0.00000000 1.1300119 0.00000000 0.3720549 6.8329051 0.02723333 0.0000000 0.06153333 0.06153333 0.03897167 0.03897167 FALSE TRUE
MSTRG.25742.2 ENSG00000164118 HEK293_OSMI2_6hA HEK293_TMG_6hB CEP44 protein_coding   7.638168 1.909736 18.24319 0.3592021 0.3889995 3.249169 0.9461543 0.06611772 2.0440954 0.03427637 0.2525338 4.7541271 0.09306667 0.0374000 0.11156667 0.07416667 0.23686505 0.03897167 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000164118 E001 22.0182748 0.0016716315 3.400667e-02 1.388783e-01 4 174283730 174283817 88 + 1.210 0.949 -0.947
ENSG00000164118 E002 28.8299376 0.0013604960 6.394608e-02 2.115669e-01 4 174283818 174283903 86 + 1.316 1.123 -0.683
ENSG00000164118 E003 16.7328270 0.0019487044 6.447255e-01 7.999939e-01 4 174283904 174283904 1 + 1.081 1.027 -0.196
ENSG00000164118 E004 17.3880433 0.0019546837 3.617674e-01 5.970904e-01 4 174283905 174283910 6 + 1.102 0.990 -0.408
ENSG00000164118 E005 16.0432569 0.0021108985 3.348587e-01 5.734440e-01 4 174283911 174283918 8 + 1.072 0.949 -0.454
ENSG00000164118 E006 17.5544483 0.0020005621 3.428837e-01 5.805711e-01 4 174283919 174283922 4 + 1.106 0.990 -0.423
ENSG00000164118 E007 19.1100492 0.0020835744 2.035528e-01 4.340034e-01 4 174283923 174283932 10 + 1.144 0.990 -0.562
ENSG00000164118 E008 20.7516786 0.0042449149 1.263985e-01 3.260984e-01 4 174283933 174283943 11 + 1.177 0.990 -0.678
ENSG00000164118 E009 4.3574645 0.0108330731 1.327844e-01 3.361634e-01 4 174283944 174283968 25 + 0.612 0.273 -1.820
ENSG00000164118 E010 5.7955570 0.0390485038 5.371697e-01 7.271012e-01 4 174283969 174284017 49 + 0.693 0.559 -0.584
ENSG00000164118 E011 5.1001898 0.0392487537 6.901772e-01 8.291857e-01 4 174284018 174284020 3 + 0.648 0.559 -0.393
ENSG00000164118 E012 5.5844368 0.0054208881 5.169062e-01 7.129618e-01 4 174284021 174284025 5 + 0.681 0.560 -0.532
ENSG00000164118 E013 7.8833266 0.0386884143 7.310911e-01 8.548221e-01 4 174284026 174284061 36 + 0.801 0.730 -0.287
ENSG00000164118 E014 3.8945712 0.0071763427 9.417118e-01 9.731071e-01 4 174284062 174284140 79 + 0.543 0.560 0.076
ENSG00000164118 E015 0.0000000       4 174285434 174285574 141 +      
ENSG00000164118 E016 28.4220303 0.0015454313 8.912623e-01 9.472483e-01 4 174297966 174298062 97 + 1.291 1.307 0.058
ENSG00000164118 E017 0.1779838 0.0330575696 7.545590e-01   4 174299070 174299071 2 + 0.049 0.001 -5.280
ENSG00000164118 E018 54.3845142 0.0007099007 5.762728e-02 1.974545e-01 4 174299072 174299210 139 + 1.576 1.436 -0.481
ENSG00000164118 E019 47.7344197 0.0008479325 6.367640e-01 7.948750e-01 4 174302039 174302186 148 + 1.508 1.476 -0.111
ENSG00000164118 E020 47.5517005 0.0019594774 7.810340e-01 8.853008e-01 4 174303703 174303849 147 + 1.501 1.524 0.080
ENSG00000164118 E021 53.8334483 0.0010034687 3.557908e-01 5.923543e-01 4 174304247 174304369 123 + 1.565 1.501 -0.222
ENSG00000164118 E022 55.9610287 0.0007090118 3.399932e-02 1.388633e-01 4 174308689 174308799 111 + 1.592 1.436 -0.536
ENSG00000164118 E023 44.6577813 0.0009957018 3.936272e-03 2.879083e-02 4 174308800 174308859 60 + 1.502 1.247 -0.886
ENSG00000164118 E024 72.2587665 0.0007564160 1.665708e-01 3.859779e-01 4 174309850 174310056 207 + 1.691 1.607 -0.286
ENSG00000164118 E025 43.6701923 0.0035633767 8.170777e-01 9.064567e-01 4 174310783 174310858 76 + 1.466 1.489 0.080
ENSG00000164118 E026 53.3941598 0.0007867757 6.072551e-01 7.750621e-01 4 174316166 174316290 125 + 1.548 1.588 0.135
ENSG00000164118 E027 8.4119372 0.0069271604 4.531795e-01 6.680872e-01 4 174316291 174316529 239 + 0.787 0.904 0.457
ENSG00000164118 E028 22.8542654 0.0016199212 9.898309e-01 9.966504e-01 4 174316530 174316567 38 + 1.197 1.202 0.018
ENSG00000164118 E029 9.6676041 0.0036369064 1.478183e-01 3.591831e-01 4 174316568 174316686 119 + 0.826 1.028 0.760
ENSG00000164118 E030 15.5876367 0.0022536828 5.053442e-01 7.045322e-01 4 174317335 174317379 45 + 1.040 1.123 0.299
ENSG00000164118 E031 126.7023978 0.0063667396 9.247594e-01 9.647078e-01 4 174317380 174318539 1160 + 1.925 1.927 0.008
ENSG00000164118 E032 6.9658210 0.0061904427 2.490458e-03 2.027114e-02 4 174318540 174318665 126 + 0.670 1.093 1.629
ENSG00000164118 E033 10.3548686 0.0191165677 4.621952e-01 6.746433e-01 4 174318666 174318834 169 + 0.882 0.989 0.404
ENSG00000164118 E034 51.6705730 0.0034154788 2.601258e-01 4.991057e-01 4 174318835 174319087 253 + 1.533 1.616 0.284
ENSG00000164118 E035 132.6089055 0.0004513978 2.361468e-08 1.018881e-06 4 174319088 174320331 1244 + 1.907 2.128 0.741
ENSG00000164118 E036 23.0536364 0.0218405978 2.069576e-02 9.831840e-02 4 174331482 174333380 1899 + 1.167 1.431 0.923