ENSG00000164088

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296487 ENSG00000164088 HEK293_OSMI2_6hA HEK293_TMG_6hB PPM1M protein_coding protein_coding 9.535417 14.40423 5.29312 1.172885 0.6179922 -1.44258 1.1134231 1.5740392 0.7796462 0.4732839 0.07362145 -1.0043297 0.12436250 0.11523333 0.14820000 0.03296667 0.8062898714 0.0001093037 FALSE TRUE
ENST00000323588 ENSG00000164088 HEK293_OSMI2_6hA HEK293_TMG_6hB PPM1M protein_coding protein_coding 9.535417 14.40423 5.29312 1.172885 0.6179922 -1.44258 1.5326453 3.0538155 0.3408705 1.5378889 0.17076778 -3.1263191 0.14975000 0.19830000 0.07000000 -0.12830000 0.9124764770 0.0001093037 FALSE TRUE
ENST00000409502 ENSG00000164088 HEK293_OSMI2_6hA HEK293_TMG_6hB PPM1M protein_coding protein_coding 9.535417 14.40423 5.29312 1.172885 0.6179922 -1.44258 1.4382817 2.4444005 0.2676663 1.4698627 0.26766629 -3.1439467 0.13490833 0.15516667 0.06593333 -0.08923333 0.7331507688 0.0001093037 FALSE TRUE
ENST00000443681 ENSG00000164088 HEK293_OSMI2_6hA HEK293_TMG_6hB PPM1M protein_coding protein_coding 9.535417 14.40423 5.29312 1.172885 0.6179922 -1.44258 0.5415939 0.4655102 0.3613442 0.3997625 0.29629678 -0.3567194 0.05018333 0.02956667 0.06166667 0.03210000 0.9345713277 0.0001093037 FALSE FALSE
ENST00000457454 ENSG00000164088 HEK293_OSMI2_6hA HEK293_TMG_6hB PPM1M protein_coding protein_coding 9.535417 14.40423 5.29312 1.172885 0.6179922 -1.44258 0.2573267 0.0000000 0.7258494 0.0000000 0.36503802 6.2013385 0.03739583 0.00000000 0.12293333 0.12293333 0.1158600254 0.0001093037 FALSE FALSE
ENST00000482724 ENSG00000164088 HEK293_OSMI2_6hA HEK293_TMG_6hB PPM1M protein_coding retained_intron 9.535417 14.40423 5.29312 1.172885 0.6179922 -1.44258 1.5749348 2.1512448 1.4138024 0.3820619 0.22345173 -0.6021136 0.18340417 0.15570000 0.26986667 0.11416667 0.4622997924 0.0001093037 FALSE TRUE
ENST00000489606 ENSG00000164088 HEK293_OSMI2_6hA HEK293_TMG_6hB PPM1M protein_coding retained_intron 9.535417 14.40423 5.29312 1.172885 0.6179922 -1.44258 1.2376436 1.5651507 1.1982310 0.4202400 0.20457686 -0.3825936 0.14405000 0.11436667 0.22380000 0.10943333 0.3468576513 0.0001093037 TRUE TRUE
MSTRG.23038.2 ENSG00000164088 HEK293_OSMI2_6hA HEK293_TMG_6hB PPM1M protein_coding   9.535417 14.40423 5.29312 1.172885 0.6179922 -1.44258 1.4644450 2.5508902 0.0000000 0.7897711 0.00000000 -8.0005016 0.13440417 0.18580000 0.00000000 -0.18580000 0.0001093037 0.0001093037 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000164088 E001 0.810937 1.2137254870 1.000000000   3 52245759 52245783 25 + 0.001 0.240 8.387
ENSG00000164088 E002 2.655835 0.2941229041 0.663789379 0.81228948 3 52245784 52245885 102 + 0.362 0.514 0.800
ENSG00000164088 E003 2.917572 0.3143209589 0.593281779 0.76582550 3 52245886 52245897 12 + 0.362 0.550 0.970
ENSG00000164088 E004 19.223946 0.0147011522 0.145861781 0.35615518 3 52245898 52246048 151 + 1.080 1.236 0.558
ENSG00000164088 E005 7.547013 0.0825573579 0.040349071 0.15561158 3 52246170 52246208 39 + 1.103 0.758 -1.304
ENSG00000164088 E006 11.413000 0.0771642176 0.094844700 0.27268714 3 52246209 52246314 106 + 1.205 0.939 -0.966
ENSG00000164088 E007 16.350488 0.1106757725 0.103049687 0.28725123 3 52246446 52246694 249 + 1.346 1.079 -0.946
ENSG00000164088 E008 40.005880 0.0527468074 0.164398672 0.38325703 3 52246695 52246812 118 + 1.393 1.541 0.509
ENSG00000164088 E009 45.164135 0.0009382367 0.405878750 0.63296836 3 52246974 52247228 255 + 1.533 1.576 0.148
ENSG00000164088 E010 3.003561 0.2190374653 0.324536805 0.56383205 3 52247327 52247681 355 + 0.687 0.487 -0.901
ENSG00000164088 E011 56.821788 0.0007852352 0.540285967 0.72920528 3 52247682 52247794 113 + 1.648 1.673 0.084
ENSG00000164088 E012 56.781789 0.0007033809 0.158691403 0.37481055 3 52248153 52248237 85 + 1.609 1.680 0.244
ENSG00000164088 E013 9.162792 0.0491682697 0.099527539 0.28090807 3 52248238 52248334 97 + 1.105 0.858 -0.916
ENSG00000164088 E014 52.021677 0.0007247266 0.044824645 0.16718831 3 52248335 52248425 91 + 1.533 1.647 0.390
ENSG00000164088 E015 40.487667 0.0012396572 0.015627779 0.08046193 3 52248426 52248453 28 + 1.387 1.553 0.570
ENSG00000164088 E016 10.249646 0.0669396840 0.115065262 0.30758855 3 52248454 52248636 183 + 1.145 0.904 -0.888
ENSG00000164088 E017 52.967246 0.0008996138 0.649691054 0.80329078 3 52248637 52248700 64 + 1.622 1.639 0.057
ENSG00000164088 E018 38.663489 0.0010261306 0.582774464 0.75887014 3 52248956 52248960 5 + 1.541 1.495 -0.159
ENSG00000164088 E019 74.857892 0.0008857222 0.883860484 0.94328455 3 52248961 52249063 103 + 1.797 1.781 -0.057
ENSG00000164088 E020 99.803251 0.0077471364 0.887657375 0.94543570 3 52249174 52249322 149 + 1.916 1.899 -0.059
ENSG00000164088 E021 17.670199 0.0600793486 0.038509771 0.15089780 3 52249323 52249644 322 + 1.387 1.105 -0.997
ENSG00000164088 E022 10.268439 0.0037904827 0.005474181 0.03708924 3 52249645 52249669 25 + 1.202 0.888 -1.151
ENSG00000164088 E023 249.487350 0.0024638088 0.962966577 0.98342347 3 52249670 52250599 930 + 2.308 2.295 -0.043