ENSG00000164073

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000505284 ENSG00000164073 HEK293_OSMI2_6hA HEK293_TMG_6hB MFSD8 protein_coding processed_transcript 9.692688 1.982586 17.37033 0.27705 0.8593892 3.124741 0.14418385 0.1367610 0.1528105 0.0179704 0.07752729 0.149725 0.03321667 0.07143333 0.009233333 -0.06220000 9.467570e-02 1.049401e-08 FALSE TRUE
ENST00000641228 ENSG00000164073 HEK293_OSMI2_6hA HEK293_TMG_6hB MFSD8 protein_coding protein_coding 9.692688 1.982586 17.37033 0.27705 0.8593892 3.124741 0.06265428 0.1031330 0.0000000 0.1031330 0.00000000 -3.499948 0.01167917 0.05823333 0.000000000 -0.05823333 5.695863e-01 1.049401e-08 FALSE TRUE
ENST00000641434 ENSG00000164073 HEK293_OSMI2_6hA HEK293_TMG_6hB MFSD8 protein_coding nonsense_mediated_decay 9.692688 1.982586 17.37033 0.27705 0.8593892 3.124741 0.96562922 0.0000000 2.3363990 0.0000000 0.24927420 7.874305 0.07399167 0.00000000 0.134533333 0.13453333 3.004106e-06 1.049401e-08 TRUE TRUE
ENST00000641508 ENSG00000164073 HEK293_OSMI2_6hA HEK293_TMG_6hB MFSD8 protein_coding nonsense_mediated_decay 9.692688 1.982586 17.37033 0.27705 0.8593892 3.124741 0.05478011 0.4382409 0.0000000 0.1112523 0.00000000 -5.486202 0.02987500 0.23900000 0.000000000 -0.23900000 1.049401e-08 1.049401e-08 FALSE TRUE
ENST00000641509 ENSG00000164073 HEK293_OSMI2_6hA HEK293_TMG_6hB MFSD8 protein_coding protein_coding 9.692688 1.982586 17.37033 0.27705 0.8593892 3.124741 0.32878889 0.1765331 0.6631173 0.1765331 0.49532929 1.851426 0.03870000 0.10730000 0.035700000 -0.07160000 9.660893e-01 1.049401e-08 FALSE TRUE
ENST00000641538 ENSG00000164073 HEK293_OSMI2_6hA HEK293_TMG_6hB MFSD8 protein_coding protein_coding 9.692688 1.982586 17.37033 0.27705 0.8593892 3.124741 0.85099795 0.0000000 2.5443668 0.0000000 0.88649721 7.996822 0.06341667 0.00000000 0.142366667 0.14236667 4.838962e-04 1.049401e-08 FALSE FALSE
ENST00000641686 ENSG00000164073 HEK293_OSMI2_6hA HEK293_TMG_6hB MFSD8 protein_coding protein_coding 9.692688 1.982586 17.37033 0.27705 0.8593892 3.124741 1.29980927 0.0000000 1.2203738 0.0000000 1.22037379 6.942953 0.11215417 0.00000000 0.074166667 0.07416667 1.000000e+00 1.049401e-08 FALSE TRUE
ENST00000641690 ENSG00000164073 HEK293_OSMI2_6hA HEK293_TMG_6hB MFSD8 protein_coding protein_coding 9.692688 1.982586 17.37033 0.27705 0.8593892 3.124741 0.38534610 0.0000000 1.1105082 0.0000000 0.27016773 6.808009 0.02321667 0.00000000 0.063533333 0.06353333 1.200973e-02 1.049401e-08 FALSE TRUE
ENST00000641742 ENSG00000164073 HEK293_OSMI2_6hA HEK293_TMG_6hB MFSD8 protein_coding nonsense_mediated_decay 9.692688 1.982586 17.37033 0.27705 0.8593892 3.124741 1.88343110 0.2413941 3.1839299 0.2413941 0.80337026 3.667310 0.18906250 0.09533333 0.180333333 0.08500000 5.608621e-01 1.049401e-08 FALSE TRUE
ENST00000641748 ENSG00000164073 HEK293_OSMI2_6hA HEK293_TMG_6hB MFSD8 protein_coding nonsense_mediated_decay 9.692688 1.982586 17.37033 0.27705 0.8593892 3.124741 0.09676696 0.1981645 0.0000000 0.1981645 0.00000000 -4.379652 0.02553333 0.07826667 0.000000000 -0.07826667 5.370376e-01 1.049401e-08 TRUE TRUE
ENST00000641776 ENSG00000164073 HEK293_OSMI2_6hA HEK293_TMG_6hB MFSD8 protein_coding nonsense_mediated_decay 9.692688 1.982586 17.37033 0.27705 0.8593892 3.124741 0.08675135 0.1181576 0.2734161 0.1181576 0.27341612 1.145003 0.01242083 0.06673333 0.016633333 -0.05010000 8.661571e-01 1.049401e-08 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000164073 E001 0.0000000       4 127917799 127917803 5 -      
ENSG00000164073 E002 0.0000000       4 127917804 127917804 1 -      
ENSG00000164073 E003 0.0000000       4 127917805 127917813 9 -      
ENSG00000164073 E004 0.0000000       4 127917814 127917819 6 -      
ENSG00000164073 E005 0.0000000       4 127917820 127917824 5 -      
ENSG00000164073 E006 0.2735028 0.0254817544 1.891307e-01   4 127917825 127917826 2 - 0.053 0.254 2.600
ENSG00000164073 E007 0.2735028 0.0254817544 1.891307e-01   4 127917827 127917834 8 - 0.053 0.254 2.600
ENSG00000164073 E008 0.2735028 0.0254817544 1.891307e-01   4 127917835 127917845 11 - 0.053 0.254 2.600
ENSG00000164073 E009 0.2735028 0.0254817544 1.891307e-01   4 127917846 127917848 3 - 0.053 0.254 2.600
ENSG00000164073 E010 0.2735028 0.0254817544 1.891307e-01   4 127917849 127917851 3 - 0.053 0.254 2.600
ENSG00000164073 E011 0.2735028 0.0254817544 1.891307e-01   4 127917852 127917859 8 - 0.053 0.254 2.600
ENSG00000164073 E012 0.2735028 0.0254817544 1.891307e-01   4 127917860 127917861 2 - 0.053 0.254 2.600
ENSG00000164073 E013 2.5342464 0.0093570568 2.286960e-02 0.105532296 4 127917862 127917888 27 - 0.364 0.761 1.862
ENSG00000164073 E014 3.1166012 0.0329615247 9.594564e-03 0.056372045 4 127917889 127917897 9 - 0.410 0.864 2.003
ENSG00000164073 E015 4.0916282 0.0092543570 1.084264e-02 0.061702630 4 127917898 127917924 27 - 0.509 0.910 1.680
ENSG00000164073 E016 4.0916282 0.0092543570 1.084264e-02 0.061702630 4 127917925 127917932 8 - 0.509 0.910 1.680
ENSG00000164073 E017 4.2696121 0.0167781496 1.710533e-02 0.085841576 4 127917933 127917959 27 - 0.526 0.910 1.594
ENSG00000164073 E018 39.2011231 0.0010011632 7.492480e-03 0.046998687 4 127917960 127918294 335 - 1.424 1.610 0.637
ENSG00000164073 E019 24.0503074 0.0020596975 6.443980e-01 0.799719435 4 127918295 127918298 4 - 1.243 1.285 0.147
ENSG00000164073 E020 35.7432897 0.0010529252 5.670149e-02 0.195298984 4 127918299 127918387 89 - 1.395 1.536 0.485
ENSG00000164073 E021 17.2621994 0.0107697605 3.005937e-02 0.127523686 4 127918388 127918389 2 - 1.083 1.317 0.829
ENSG00000164073 E022 98.4442050 0.0013452786 8.673315e-01 0.934480631 4 127918390 127919193 804 - 1.849 1.855 0.022
ENSG00000164073 E023 7.1591786 0.0040500652 5.587027e-01 0.742344696 4 127919194 127919214 21 - 0.795 0.697 -0.398
ENSG00000164073 E024 7.3715367 0.0239530598 5.432263e-01 0.731389261 4 127919215 127919238 24 - 0.811 0.697 -0.459
ENSG00000164073 E025 10.7363379 0.0145391304 8.675769e-01 0.934603954 4 127919239 127919290 52 - 0.933 0.952 0.069
ENSG00000164073 E026 9.7297672 0.0058394233 6.530636e-01 0.805425852 4 127919291 127919312 22 - 0.892 0.951 0.224
ENSG00000164073 E027 9.6188975 0.0037340152 2.391893e-01 0.475653299 4 127919313 127919338 26 - 0.870 1.023 0.572
ENSG00000164073 E028 35.0663341 0.0012002714 6.555624e-01 0.807092763 4 127919339 127919780 442 - 1.419 1.381 -0.134
ENSG00000164073 E029 25.5102906 0.0336181656 6.587156e-01 0.809179809 4 127919781 127920056 276 - 1.283 1.213 -0.247
ENSG00000164073 E030 17.7468380 0.0808667514 9.585905e-01 0.981163491 4 127920057 127920188 132 - 1.127 1.122 -0.021
ENSG00000164073 E031 8.1023526 0.0494294515 3.040645e-01 0.544626765 4 127920189 127920218 30 - 0.800 0.955 0.594
ENSG00000164073 E032 5.7642061 0.0538617110 6.760395e-01 0.820227265 4 127920219 127920219 1 - 0.722 0.622 -0.421
ENSG00000164073 E033 11.3014776 0.0477320681 1.477728e-01 0.359108718 4 127920220 127920253 34 - 0.985 0.699 -1.116
ENSG00000164073 E034 10.7911088 0.0397165034 2.927906e-01 0.533505238 4 127920254 127920264 11 - 0.962 0.762 -0.770
ENSG00000164073 E035 12.9196443 0.0080739713 1.400450e-01 0.347568726 4 127920265 127920301 37 - 1.034 0.817 -0.820
ENSG00000164073 E036 13.4120194 0.0090043998 1.206899e-01 0.316955506 4 127920302 127920321 20 - 1.045 0.817 -0.861
ENSG00000164073 E037 14.4336482 0.0028150561 4.027440e-01 0.630569588 4 127920322 127920339 18 - 1.060 0.951 -0.401
ENSG00000164073 E038 31.0885022 0.0046527564 3.475760e-01 0.584991127 4 127920340 127920452 113 - 1.342 1.422 0.277
ENSG00000164073 E039 16.6703966 0.0107497196 5.305696e-01 0.722430028 4 127920453 127920456 4 - 1.090 1.162 0.258
ENSG00000164073 E040 50.3560685 0.0309609300 9.546895e-01 0.979253425 4 127920457 127920556 100 - 1.561 1.552 -0.030
ENSG00000164073 E041 46.0341756 0.0017543878 7.993824e-01 0.895958349 4 127920557 127920617 61 - 1.521 1.537 0.053
ENSG00000164073 E042 32.7197998 0.0011193776 2.153530e-01 0.447915955 4 127920618 127920627 10 - 1.397 1.285 -0.391
ENSG00000164073 E043 42.1118242 0.0011516907 6.950120e-01 0.832315719 4 127920628 127920655 28 - 1.491 1.459 -0.109
ENSG00000164073 E044 71.6665315 0.0008672837 2.051629e-01 0.436106039 4 127920656 127920836 181 - 1.722 1.643 -0.269
ENSG00000164073 E045 12.7083926 0.0282731764 2.401560e-01 0.476760635 4 127920837 127921117 281 - 0.963 1.115 0.559
ENSG00000164073 E046 9.0715233 0.1025962475 3.496232e-01 0.586926464 4 127921118 127921198 81 - 0.837 0.992 0.584
ENSG00000164073 E047 10.9311745 0.0342767394 6.217856e-01 0.785013453 4 127921199 127921356 158 - 0.924 0.990 0.247
ENSG00000164073 E048 7.0709639 0.0046629607 6.858195e-01 0.826359446 4 127921357 127921466 110 - 0.757 0.818 0.240
ENSG00000164073 E049 4.6999843 0.0062242124 9.687760e-01 0.986221236 4 127921467 127921523 57 - 0.631 0.621 -0.042
ENSG00000164073 E050 66.4792513 0.0007920785 9.369801e-01 0.970691022 4 127921524 127921771 248 - 1.684 1.687 0.011
ENSG00000164073 E051 0.5963342 0.0218918881 5.459052e-01   4 127921772 127921859 88 - 0.144 0.254 1.014
ENSG00000164073 E052 30.6661999 0.0038214023 1.956300e-01 0.424145586 4 127921860 127921925 66 - 1.372 1.247 -0.436
ENSG00000164073 E053 31.9273377 0.0113697778 4.201932e-01 0.643780780 4 127921926 127921963 38 - 1.384 1.301 -0.288
ENSG00000164073 E054 0.3337900 0.0284701974 1.882599e-01   4 127921964 127921982 19 - 0.053 0.254 2.602
ENSG00000164073 E055 0.1723744 0.0355442933 5.806221e-02   4 127921983 127921989 7 - 0.000 0.254 13.652
ENSG00000164073 E056 0.0000000       4 127930673 127930682 10 -      
ENSG00000164073 E057 21.0561975 0.0035625640 8.663048e-01 0.933942825 4 127930683 127930687 5 - 1.203 1.184 -0.065
ENSG00000164073 E058 49.3193053 0.0009394774 5.679127e-01 0.748733366 4 127930688 127930817 130 - 1.558 1.516 -0.144
ENSG00000164073 E059 0.0000000       4 127932319 127932339 21 -      
ENSG00000164073 E060 0.0000000       4 127932340 127932369 30 -      
ENSG00000164073 E061 0.0000000       4 127932370 127932421 52 -      
ENSG00000164073 E062 0.3807181 0.0369285395 1.890851e-01   4 127932422 127932663 242 - 0.054 0.254 2.603
ENSG00000164073 E063 0.7260870 0.2193201349 1.192821e-01   4 127932664 127932914 251 - 0.101 0.421 2.643
ENSG00000164073 E064 0.4514866 0.0217681645 3.682208e-01   4 127932915 127932984 70 - 0.101 0.254 1.599
ENSG00000164073 E065 35.7638851 0.0012485284 9.582260e-01 0.981023689 4 127932985 127933017 33 - 1.419 1.422 0.008
ENSG00000164073 E066 38.9454919 0.0010749469 9.217000e-01 0.963150038 4 127933018 127933064 47 - 1.457 1.447 -0.033
ENSG00000164073 E067 30.8726757 0.0033248011 1.747847e-01 0.396866917 4 127933065 127933093 29 - 1.378 1.247 -0.457
ENSG00000164073 E068 1.4295343 0.0127512264 2.117059e-01 0.443769163 4 127933094 127933713 620 - 0.338 0.000 -13.336
ENSG00000164073 E069 0.1723744 0.0355442933 5.806221e-02   4 127934558 127934662 105 - 0.000 0.254 13.652
ENSG00000164073 E070 33.0749303 0.0011496568 4.842688e-02 0.175997214 4 127938783 127938836 54 - 1.411 1.227 -0.640
ENSG00000164073 E071 20.7723201 0.0016606659 1.523575e-01 0.365764381 4 127938837 127938838 2 - 1.216 1.054 -0.582
ENSG00000164073 E072 0.9902238 0.1785572789 5.505791e-02   4 127938839 127939079 241 - 0.144 0.531 2.604
ENSG00000164073 E073 3.8959763 0.0070044844 3.779797e-01 0.610528114 4 127939080 127939480 401 - 0.543 0.697 0.674
ENSG00000164073 E074 2.5877068 0.0086374511 2.539412e-01 0.492323322 4 127939481 127939596 116 - 0.410 0.621 1.017
ENSG00000164073 E075 0.1779838 0.0354137426 9.582214e-01   4 127939597 127939601 5 - 0.054 0.000 -10.454
ENSG00000164073 E076 0.1614157 0.0333416689 9.568645e-01   4 127939779 127939852 74 - 0.053 0.000 -10.456
ENSG00000164073 E077 41.9857960 0.0012365152 4.165636e-02 0.159028159 4 127939853 127939997 145 - 1.506 1.336 -0.588
ENSG00000164073 E078 32.0372889 0.0014257600 3.663770e-01 0.601011671 4 127942045 127942070 26 - 1.384 1.302 -0.284
ENSG00000164073 E079 37.2067390 0.0155655187 1.765617e-01 0.399155662 4 127942071 127942149 79 - 1.453 1.315 -0.478
ENSG00000164073 E080 16.4007555 0.0635325093 1.070416e-01 0.294040290 4 127942150 127942158 9 - 1.132 0.857 -1.017
ENSG00000164073 E081 2.3600345 0.0096765512 5.403312e-01 0.729231621 4 127943391 127943751 361 - 0.410 0.529 0.599
ENSG00000164073 E082 21.9806120 0.0346584395 1.720818e-01 0.393302992 4 127943752 127943755 4 - 1.242 1.049 -0.693
ENSG00000164073 E083 68.7485365 0.0212332902 2.319707e-01 0.467450911 4 127943756 127943992 237 - 1.709 1.602 -0.364
ENSG00000164073 E084 0.0000000       4 127945335 127945630 296 -      
ENSG00000164073 E085 33.4914154 0.0012324804 7.676627e-01 0.877229214 4 127949804 127949847 44 - 1.386 1.409 0.078
ENSG00000164073 E086 43.9165943 0.0067527258 5.334328e-01 0.724525266 4 127957501 127957590 90 - 1.496 1.545 0.165
ENSG00000164073 E087 27.1677815 0.0049775986 4.050572e-01 0.632324266 4 127957591 127957592 2 - 1.290 1.366 0.263
ENSG00000164073 E088 4.3599262 0.0499752750 6.303444e-05 0.001015722 4 127964659 127965071 413 - 0.431 1.085 2.716
ENSG00000164073 E089 33.9465088 0.0070052959 1.140080e-01 0.305805795 4 127965072 127965208 137 - 1.373 1.504 0.454
ENSG00000164073 E090 0.6434498 0.0195618969 7.307110e-01   4 127965209 127965222 14 - 0.183 0.000 -12.332
ENSG00000164073 E091 0.3040503 0.0274424043 1.000000e+00   4 127965223 127965242 20 - 0.101 0.000 -11.412
ENSG00000164073 E092 0.0000000       4 127965243 127965482 240 -      
ENSG00000164073 E093 1.1089159 0.0205040472 3.283409e-01   4 127965897 127966034 138 - 0.283 0.000 -13.034