ENSG00000164050

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296440 ENSG00000164050 HEK293_OSMI2_6hA HEK293_TMG_6hB PLXNB1 protein_coding protein_coding 3.87166 5.189316 2.797244 0.9559893 0.2385129 -0.8891675 0.74495384 1.0156548 0.5223844 0.51216285 0.26247346 -0.9460050 0.197770833 0.16943333 0.19990000 0.03046667 1.000000000 0.002667432 FALSE TRUE
ENST00000358536 ENSG00000164050 HEK293_OSMI2_6hA HEK293_TMG_6hB PLXNB1 protein_coding protein_coding 3.87166 5.189316 2.797244 0.9559893 0.2385129 -0.8891675 0.30947551 0.5856778 0.3175693 0.41871130 0.27073694 -0.8627321 0.089716667 0.15073333 0.10483333 -0.04590000 0.997477891 0.002667432 FALSE TRUE
ENST00000462738 ENSG00000164050 HEK293_OSMI2_6hA HEK293_TMG_6hB PLXNB1 protein_coding retained_intron 3.87166 5.189316 2.797244 0.9559893 0.2385129 -0.8891675 0.22588561 0.1768776 0.3058713 0.14006389 0.07905909 0.7572428 0.059108333 0.02710000 0.10683333 0.07973333 0.291826709 0.002667432 FALSE FALSE
ENST00000473996 ENSG00000164050 HEK293_OSMI2_6hA HEK293_TMG_6hB PLXNB1 protein_coding retained_intron 3.87166 5.189316 2.797244 0.9559893 0.2385129 -0.8891675 0.02460536 0.0000000 0.1301188 0.00000000 0.13011880 3.8085786 0.009075000 0.00000000 0.05606667 0.05606667 0.793731236 0.002667432 FALSE FALSE
ENST00000484485 ENSG00000164050 HEK293_OSMI2_6hA HEK293_TMG_6hB PLXNB1 protein_coding processed_transcript 3.87166 5.189316 2.797244 0.9559893 0.2385129 -0.8891675 0.02707092 0.0000000 0.1615132 0.00000000 0.08689675 4.1002474 0.008133333 0.00000000 0.05323333 0.05323333 0.167116068 0.002667432 FALSE FALSE
ENST00000485535 ENSG00000164050 HEK293_OSMI2_6hA HEK293_TMG_6hB PLXNB1 protein_coding retained_intron 3.87166 5.189316 2.797244 0.9559893 0.2385129 -0.8891675 0.91863361 1.4745408 0.1595245 0.11256111 0.09866696 -3.1304512 0.227720833 0.30366667 0.05250000 -0.25116667 0.094306162 0.002667432 FALSE TRUE
MSTRG.22905.6 ENSG00000164050 HEK293_OSMI2_6hA HEK293_TMG_6hB PLXNB1 protein_coding   3.87166 5.189316 2.797244 0.9559893 0.2385129 -0.8891675 0.16118007 0.2883567 0.0000000 0.02067298 0.00000000 -4.8989663 0.039712500 0.05816667 0.00000000 -0.05816667 0.002667432 0.002667432 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000164050 E001 0.0000000       3 48403854 48403855 2 -      
ENSG00000164050 E002 35.4742683 0.196862559 0.066142717 0.21640185 3 48403856 48404185 330 - 1.211 1.564 1.226
ENSG00000164050 E003 21.6510991 0.054556634 0.007597311 0.04746866 3 48404186 48404230 45 - 0.967 1.364 1.418
ENSG00000164050 E004 22.2737375 0.013053965 0.001852640 0.01607259 3 48404231 48404305 75 - 1.019 1.374 1.263
ENSG00000164050 E005 31.6251676 0.119765788 0.030572056 0.12906801 3 48404306 48404485 180 - 1.149 1.519 1.290
ENSG00000164050 E006 13.6303307 0.003163544 0.005282213 0.03608662 3 48404486 48404508 23 - 0.818 1.171 1.310
ENSG00000164050 E007 12.5046297 0.022213394 0.005275710 0.03606043 3 48404509 48404547 39 - 0.736 1.147 1.552
ENSG00000164050 E008 16.6012948 0.036970038 0.005260952 0.03599205 3 48404548 48404590 43 - 0.851 1.258 1.493
ENSG00000164050 E009 22.3785099 0.031386343 0.020986072 0.09930944 3 48405724 48405798 75 - 1.064 1.366 1.071
ENSG00000164050 E010 0.8371940 0.362710296 0.228583424   3 48405799 48406065 267 - 0.435 0.136 -2.226
ENSG00000164050 E011 1.6004653 0.012264634 0.753822119 0.86902087 3 48406723 48406822 100 - 0.325 0.397 0.423
ENSG00000164050 E012 23.3292142 0.022469821 0.147172738 0.35827574 3 48406823 48406898 76 - 1.190 1.362 0.604
ENSG00000164050 E013 0.0000000       3 48407022 48407026 5 -      
ENSG00000164050 E014 21.2277860 0.003352916 0.009821576 0.05735264 3 48407027 48407091 65 - 1.064 1.334 0.958
ENSG00000164050 E015 18.5763320 0.044713418 0.453195175 0.66809869 3 48409329 48409398 70 - 1.137 1.252 0.407
ENSG00000164050 E016 16.1451417 0.002306498 0.683452986 0.82486395 3 48409399 48409476 78 - 1.190 1.171 -0.068
ENSG00000164050 E017 0.1723744 0.030816482 1.000000000   3 48409477 48409570 94 - 0.000 0.074 7.451
ENSG00000164050 E018 21.7048895 0.004084819 0.744661352 0.86348948 3 48409571 48409731 161 - 1.300 1.290 -0.037
ENSG00000164050 E019 16.3723085 0.005115814 0.767726668 0.87726332 3 48409905 48410014 110 - 1.141 1.192 0.180
ENSG00000164050 E020 14.2500047 0.003039169 0.538708340 0.72811192 3 48410015 48410077 63 - 1.158 1.118 -0.145
ENSG00000164050 E021 17.1703318 0.002064317 0.930036358 0.96703259 3 48410296 48410380 85 - 1.190 1.202 0.043
ENSG00000164050 E022 0.0000000       3 48410381 48410383 3 -      
ENSG00000164050 E023 20.5653234 0.001869110 0.646774190 0.80131562 3 48410455 48410558 104 - 1.288 1.268 -0.069
ENSG00000164050 E024 3.2436696 0.008083801 0.927504920 0.96583102 3 48410559 48410867 309 - 0.578 0.580 0.006
ENSG00000164050 E025 20.6267196 0.002813491 0.008698150 0.05247410 3 48410868 48410946 79 - 1.416 1.222 -0.680
ENSG00000164050 E026 15.5483841 0.005213623 0.944611894 0.97464317 3 48410947 48411005 59 - 1.158 1.169 0.042
ENSG00000164050 E027 14.4498745 0.002237132 0.354846939 0.59161627 3 48411006 48411036 31 - 1.043 1.159 0.421
ENSG00000164050 E028 31.5989545 0.001153760 0.391513559 0.62163733 3 48411863 48412009 147 - 1.388 1.471 0.286
ENSG00000164050 E029 3.1012226 0.160917706 0.831316775 0.91454646 3 48412010 48412237 228 - 0.581 0.559 -0.102
ENSG00000164050 E030 22.3023067 0.001744431 0.271728150 0.51158167 3 48412238 48412304 67 - 1.221 1.336 0.406
ENSG00000164050 E031 30.4816842 0.001346264 0.084679014 0.25410737 3 48412442 48412620 179 - 1.324 1.476 0.526
ENSG00000164050 E032 27.0489700 0.001998381 0.272153890 0.51201992 3 48412742 48412959 218 - 1.312 1.420 0.377
ENSG00000164050 E033 14.5772219 0.002857642 0.260802546 0.49980557 3 48413069 48413169 101 - 1.020 1.160 0.506
ENSG00000164050 E034 1.3430981 0.082465786 0.491678040   3 48413170 48413219 50 - 0.193 0.365 1.234
ENSG00000164050 E035 4.4333284 0.355942993 0.195431438 0.42390681 3 48413220 48413669 450 - 0.859 0.604 -1.044
ENSG00000164050 E036 15.3560570 0.029124087 0.580381272 0.75742996 3 48413670 48413758 89 - 1.189 1.136 -0.192
ENSG00000164050 E037 14.0002596 0.002461229 0.960019040 0.98186223 3 48413759 48413818 60 - 1.104 1.119 0.052
ENSG00000164050 E038 2.3203226 0.012404736 0.366429577 0.60103511 3 48413819 48413894 76 - 0.325 0.511 1.011
ENSG00000164050 E039 9.0967079 0.003416733 0.499906359 0.70066684 3 48413895 48413907 13 - 0.997 0.937 -0.222
ENSG00000164050 E040 15.9867527 0.007112204 0.661299812 0.81074154 3 48413908 48413986 79 - 1.190 1.170 -0.070
ENSG00000164050 E041 14.7398091 0.003372111 0.083916680 0.25260982 3 48413987 48414071 85 - 1.248 1.105 -0.509
ENSG00000164050 E042 23.7847743 0.001518974 0.138365582 0.34508185 3 48414799 48414990 192 - 1.407 1.314 -0.325
ENSG00000164050 E043 11.9394733 0.003509551 0.311048290 0.55142581 3 48414991 48415041 51 - 1.123 1.037 -0.311
ENSG00000164050 E044 9.9251407 0.003009807 0.766019673 0.87624787 3 48415176 48415211 36 - 0.997 0.981 -0.056
ENSG00000164050 E045 16.9494233 0.002589821 0.070249592 0.22525944 3 48415212 48415347 136 - 1.300 1.159 -0.499
ENSG00000164050 E046 0.8868825 0.019167347 0.441081952   3 48415348 48415535 188 - 0.326 0.194 -0.991
ENSG00000164050 E047 16.6389778 0.045243899 0.729782773 0.85410395 3 48415583 48415759 177 - 1.194 1.176 -0.065
ENSG00000164050 E048 12.4542117 0.003215539 0.366223595 0.60091503 3 48416031 48416167 137 - 0.971 1.093 0.447
ENSG00000164050 E049 10.2091248 0.004149833 0.518860726 0.71425463 3 48416346 48416451 106 - 1.043 0.989 -0.196
ENSG00000164050 E050 5.6442596 0.117859936 0.233620061 0.46932666 3 48416452 48416833 382 - 0.891 0.712 -0.709
ENSG00000164050 E051 13.9137327 0.015671781 0.070985697 0.22669157 3 48417911 48418062 152 - 1.248 1.076 -0.612
ENSG00000164050 E052 0.6238610 0.019618156 0.268163776   3 48418189 48418190 2 - 0.325 0.138 -1.580
ENSG00000164050 E053 12.6236942 0.002771031 0.083718127 0.25220882 3 48418191 48418286 96 - 1.190 1.037 -0.552
ENSG00000164050 E054 11.4340466 0.002986792 0.197500695 0.42649169 3 48418287 48418363 77 - 1.123 1.006 -0.424
ENSG00000164050 E055 11.6363059 0.006303481 0.055091152 0.19153553 3 48418449 48418542 94 - 1.175 0.989 -0.672
ENSG00000164050 E056 13.0262189 0.004171679 0.048800903 0.17679021 3 48418917 48419039 123 - 1.221 1.044 -0.636
ENSG00000164050 E057 10.2986490 0.003747667 0.865443396 0.93338198 3 48419244 48419366 123 - 0.997 0.998 0.004
ENSG00000164050 E058 3.1171935 0.022332203 0.036271068 0.14498097 3 48419367 48419576 210 - 0.780 0.458 -1.423
ENSG00000164050 E059 8.6927873 0.006161793 0.297577113 0.53807151 3 48419577 48419674 98 - 1.020 0.917 -0.386
ENSG00000164050 E060 16.6869334 0.002648051 0.025090351 0.11250842 3 48419675 48420078 404 - 1.312 1.131 -0.643
ENSG00000164050 E061 8.9872483 0.004072151 0.779987107 0.88474362 3 48420079 48420223 145 - 0.945 0.928 -0.062
ENSG00000164050 E062 4.4330097 0.006023951 0.144964757 0.35487961 3 48420224 48420257 34 - 0.818 0.621 -0.811
ENSG00000164050 E063 9.3922000 0.004107973 0.099258129 0.28048416 3 48420665 48420773 109 - 1.085 0.918 -0.616
ENSG00000164050 E064 11.5080529 0.006269780 0.449410583 0.66528074 3 48420848 48420956 109 - 1.085 1.022 -0.227
ENSG00000164050 E065 0.4646582 0.021768165 0.705774087   3 48421224 48421227 4 - 0.192 0.138 -0.580
ENSG00000164050 E066 15.3524104 0.009972625 0.959717084 0.98174245 3 48421228 48421384 157 - 1.140 1.160 0.069
ENSG00000164050 E067 14.7752038 0.008479551 0.501912365 0.70213404 3 48421674 48421806 133 - 1.175 1.130 -0.160
ENSG00000164050 E068 10.1324023 0.003628047 0.070521757 0.22575792 3 48422105 48422205 101 - 1.123 0.946 -0.649
ENSG00000164050 E069 11.1458988 0.003194094 0.061343408 0.20580260 3 48422331 48422412 82 - 1.158 0.981 -0.641
ENSG00000164050 E070 8.1834817 0.010408814 0.058384162 0.19915984 3 48422413 48422443 31 - 1.064 0.854 -0.785
ENSG00000164050 E071 6.0162343 0.009815669 0.307795394 0.54841142 3 48422444 48422459 16 - 0.886 0.767 -0.467
ENSG00000164050 E072 12.9956640 0.004382212 0.081846337 0.24847850 3 48422765 48422947 183 - 1.205 1.051 -0.553
ENSG00000164050 E073 37.1419073 0.006657312 0.032469031 0.13461228 3 48423505 48424617 1113 - 1.609 1.478 -0.448
ENSG00000164050 E074 3.1883244 0.010505877 0.032796848 0.13548845 3 48425281 48425333 53 - 0.780 0.458 -1.427
ENSG00000164050 E075 2.5115506 0.009255512 0.831208303 0.91448127 3 48429253 48429481 229 - 0.509 0.485 -0.118
ENSG00000164050 E076 0.4868358 0.273202803 0.173517978   3 48430008 48430086 79 - 0.329 0.073 -2.629