ENSG00000163939

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296302 ENSG00000163939 HEK293_OSMI2_6hA HEK293_TMG_6hB PBRM1 protein_coding protein_coding 18.29282 7.153837 29.09958 2.048203 1.402635 2.02269 1.248111 0.0000000 3.669151 0.0000000 0.5680051 8.523229 0.04225833 0.0000000 0.1253000 0.12530000 6.469554e-11 6.469554e-11 FALSE TRUE
ENST00000356770 ENSG00000163939 HEK293_OSMI2_6hA HEK293_TMG_6hB PBRM1 protein_coding protein_coding 18.29282 7.153837 29.09958 2.048203 1.402635 2.02269 6.981123 4.5267830 10.226233 1.5626179 0.1931063 1.173943 0.51740417 0.5968000 0.3524333 -0.24436667 5.386886e-02 6.469554e-11 FALSE TRUE
MSTRG.23059.2 ENSG00000163939 HEK293_OSMI2_6hA HEK293_TMG_6hB PBRM1 protein_coding   18.29282 7.153837 29.09958 2.048203 1.402635 2.02269 2.664958 0.8568833 4.536503 0.1921204 0.1604282 2.390847 0.11258750 0.1281333 0.1562667 0.02813333 7.012563e-01 6.469554e-11 FALSE TRUE
MSTRG.23059.3 ENSG00000163939 HEK293_OSMI2_6hA HEK293_TMG_6hB PBRM1 protein_coding   18.29282 7.153837 29.09958 2.048203 1.402635 2.02269 2.007721 0.5078663 4.609402 0.1686296 0.2547188 3.157054 0.09885417 0.0929000 0.1597667 0.06686667 6.266014e-01 6.469554e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000163939 E001 90.0985515 0.0005315115 6.006502e-19 1.520182e-16 3 52545352 52545620 269 - 1.769 2.143 1.256
ENSG00000163939 E002 181.7995087 0.0029205511 6.821246e-16 1.174852e-13 3 52545621 52545873 253 - 2.087 2.419 1.110
ENSG00000163939 E003 362.0640947 0.0043621520 6.021525e-08 2.356749e-06 3 52545874 52546690 817 - 2.422 2.654 0.771
ENSG00000163939 E004 416.9277232 0.0017169596 9.220250e-06 1.956292e-04 3 52546691 52547840 1150 - 2.512 2.656 0.480
ENSG00000163939 E005 93.1745440 0.0008032924 5.701081e-01 7.503428e-01 3 52547841 52547989 149 - 1.891 1.938 0.159
ENSG00000163939 E006 35.8580605 0.0010671427 9.920144e-01 9.977309e-01 3 52547990 52547990 1 - 1.493 1.515 0.074
ENSG00000163939 E007 48.1962684 0.0007473921 7.896207e-01 8.903214e-01 3 52547991 52548009 19 - 1.615 1.653 0.130
ENSG00000163939 E008 41.8490742 0.0008479918 9.687976e-01 9.862255e-01 3 52548010 52548010 1 - 1.559 1.580 0.069
ENSG00000163939 E009 135.9049717 0.0003207977 5.589845e-02 1.934078e-01 3 52548011 52548164 154 - 2.045 2.134 0.298
ENSG00000163939 E010 57.5878477 0.0008188595 2.034451e-01 4.338501e-01 3 52548165 52548165 1 - 1.673 1.763 0.306
ENSG00000163939 E011 59.5643876 0.0007152686 2.618147e-01 5.009199e-01 3 52548166 52548172 7 - 1.690 1.772 0.275
ENSG00000163939 E012 73.7602219 0.0006114947 8.742809e-02 2.590248e-01 3 52548173 52548210 38 - 1.776 1.878 0.346
ENSG00000163939 E013 70.6094912 0.0005967181 5.836755e-01 7.593823e-01 3 52548211 52548235 25 - 1.772 1.821 0.166
ENSG00000163939 E014 142.1642034 0.0009510882 7.699672e-03 4.793187e-02 3 52550421 52550637 217 - 2.056 2.174 0.397
ENSG00000163939 E015 68.4513231 0.0032971121 6.991360e-03 4.459383e-02 3 52550747 52550817 71 - 1.725 1.892 0.560
ENSG00000163939 E016 49.4581902 0.0088514368 9.734610e-05 1.461939e-03 3 52554724 52554782 59 - 1.544 1.839 1.003
ENSG00000163939 E017 70.6198763 0.0149211871 4.982809e-03 3.453296e-02 3 52554783 52554879 97 - 1.716 1.952 0.797
ENSG00000163939 E018 38.0987365 0.0010765363 2.632774e-02 1.162788e-01 3 52558249 52558413 165 - 1.480 1.642 0.553
ENSG00000163939 E019 171.7442253 0.0002510262 8.884698e-03 5.330171e-02 3 52561767 52561968 202 - 2.141 2.244 0.343
ENSG00000163939 E020 97.7086893 0.0006363619 4.677932e-01 6.785742e-01 3 52563283 52563363 81 - 1.911 1.964 0.177
ENSG00000163939 E021 130.3182146 0.0041231130 8.757052e-01 9.391234e-01 3 52563364 52563474 111 - 2.039 2.069 0.098
ENSG00000163939 E022 69.2217457 0.0075707917 4.761029e-01 6.843146e-01 3 52563475 52563493 19 - 1.782 1.760 -0.075
ENSG00000163939 E023 152.0521410 0.0020713534 5.642476e-01 7.462948e-01 3 52564050 52564233 184 - 2.116 2.115 -0.003
ENSG00000163939 E024 122.2818864 0.0281763203 3.309192e-01 5.698292e-01 3 52576541 52576698 158 - 2.002 2.080 0.261
ENSG00000163939 E025 89.6541999 1.3897056242 4.617421e-01 6.743413e-01 3 52579054 52579199 146 - 1.830 2.034 0.688
ENSG00000163939 E026 9.4703344 0.1827579717 5.209662e-01 7.155385e-01 3 52585473 52586424 952 - 0.929 1.033 0.387
ENSG00000163939 E027 41.7359705 0.2490310477 2.566960e-01 4.954526e-01 3 52586425 52586429 5 - 1.513 1.694 0.616
ENSG00000163939 E028 147.2916955 0.0097639056 4.619507e-01 6.744538e-01 3 52586430 52586688 259 - 2.089 2.142 0.178
ENSG00000163939 E029 91.2565949 0.0023599283 8.972524e-01 9.504336e-01 3 52587353 52587435 83 - 1.892 1.913 0.071
ENSG00000163939 E030 88.0679119 0.0020154730 9.322223e-01 9.682469e-01 3 52587436 52587510 75 - 1.874 1.903 0.099
ENSG00000163939 E031 135.0359966 0.0007471948 8.820011e-01 9.423618e-01 3 52589070 52589252 183 - 2.059 2.078 0.061
ENSG00000163939 E032 43.8899541 0.0008015535 1.360509e-01 3.414245e-01 3 52589253 52589255 3 - 1.602 1.530 -0.246
ENSG00000163939 E033 133.8804697 0.0038543505 1.046791e-01 2.900722e-01 3 52603521 52603732 212 - 2.071 2.022 -0.167
ENSG00000163939 E034 1.2375711 0.0130690920 4.238612e-01   3 52609086 52609312 227 - 0.350 0.201 -1.079
ENSG00000163939 E035 310.8207172 0.0007750550 5.970774e-04 6.552429e-03 3 52609313 52609955 643 - 2.440 2.369 -0.237
ENSG00000163939 E036 100.2046332 0.0008948976 2.595411e-01 4.985132e-01 3 52615351 52615456 106 - 1.944 1.917 -0.092
ENSG00000163939 E037 173.3231266 0.0006657907 1.447880e-04 2.036807e-03 3 52617262 52617538 277 - 2.197 2.090 -0.360
ENSG00000163939 E038 3.1574239 0.0152264858 8.291435e-01 9.133136e-01 3 52624897 52624941 45 - 0.542 0.596 0.249
ENSG00000163939 E039 97.4380139 0.0004667905 1.256709e-03 1.183815e-02 3 52627273 52627370 98 - 1.951 1.832 -0.401
ENSG00000163939 E040 107.5448855 0.0006992023 5.569393e-04 6.193916e-03 3 52628894 52629035 142 - 1.995 1.868 -0.426
ENSG00000163939 E041 138.5547801 0.0004360983 2.788214e-06 6.975588e-05 3 52634602 52634815 214 - 2.108 1.952 -0.522
ENSG00000163939 E042 99.0047453 0.0007896407 5.227114e-05 8.644305e-04 3 52641954 52642045 92 - 1.964 1.801 -0.549
ENSG00000163939 E043 96.3424733 0.0017668552 7.858232e-03 4.867121e-02 3 52643248 52643343 96 - 1.943 1.836 -0.360
ENSG00000163939 E044 78.8584221 0.0005940457 1.537599e-02 7.949818e-02 3 52644704 52644789 86 - 1.854 1.759 -0.322
ENSG00000163939 E045 78.6455700 0.0005200806 1.162040e-03 1.114043e-02 3 52648344 52648442 99 - 1.863 1.726 -0.462
ENSG00000163939 E046 58.3427583 0.0127213770 8.407883e-02 2.529231e-01 3 52651742 52651763 22 - 1.731 1.623 -0.369
ENSG00000163939 E047 71.1615157 0.0127991564 3.367102e-03 2.557327e-02 3 52651764 52651810 47 - 1.831 1.634 -0.664
ENSG00000163939 E048 87.2141560 0.0147633529 2.191280e-03 1.834236e-02 3 52658199 52658315 117 - 1.919 1.712 -0.697
ENSG00000163939 E049 100.3172167 0.0029154919 5.821517e-06 1.315714e-04 3 52662133 52662203 71 - 1.976 1.759 -0.732
ENSG00000163939 E050 108.4934270 0.0008088563 8.366082e-08 3.164966e-06 3 52662204 52662276 73 - 2.010 1.789 -0.743
ENSG00000163939 E051 78.3967567 0.0029572141 6.877891e-06 1.516127e-04 3 52668498 52668526 29 - 1.875 1.631 -0.827
ENSG00000163939 E052 110.5794328 0.0005065763 7.220211e-10 4.317458e-08 3 52668527 52668620 94 - 2.024 1.772 -0.849
ENSG00000163939 E053 69.8928432 0.0005753714 4.659650e-11 3.535816e-09 3 52668621 52668645 25 - 1.843 1.482 -1.227
ENSG00000163939 E054 98.9780474 0.0004343710 1.125646e-10 7.898603e-09 3 52678500 52678597 98 - 1.981 1.697 -0.956
ENSG00000163939 E055 47.6562129 0.0021045268 6.010431e-06 1.350006e-04 3 52679574 52679581 8 - 1.668 1.368 -1.029
ENSG00000163939 E056 43.1840885 0.0049966666 4.684625e-05 7.865121e-04 3 52679582 52679582 1 - 1.627 1.322 -1.048
ENSG00000163939 E057 59.6689107 0.0006182644 1.749837e-06 4.637368e-05 3 52679583 52679633 51 - 1.763 1.499 -0.897
ENSG00000163939 E058 56.8042804 0.0006246153 1.710694e-03 1.509092e-02 3 52679634 52679723 90 - 1.726 1.566 -0.545
ENSG00000163939 E059 19.5371642 0.0017882016 1.732761e-01 3.948705e-01 3 52679724 52679726 3 - 1.268 1.162 -0.377
ENSG00000163939 E060 0.4820342 0.0213394023 4.936813e-01   3 52681704 52681820 117 - 0.185 0.000 -9.002
ENSG00000163939 E061 19.2156804 0.0352922831 4.529710e-01 6.678993e-01 3 52682092 52682233 142 - 1.259 1.173 -0.307
ENSG00000163939 E062 3.5714479 0.2878303895 1.261677e-01 3.257665e-01 3 52684856 52684914 59 - 0.453 0.894 1.893
ENSG00000163939 E063 3.3936020 0.0068389220 1.652993e-01 3.843533e-01 3 52685436 52685748 313 - 0.519 0.756 1.028
ENSG00000163939 E064 22.6356513 0.0019157731 1.998562e-01 4.295047e-01 3 52685749 52685917 169 - 1.272 1.399 0.441