ENSG00000163872

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000305135 ENSG00000163872 HEK293_OSMI2_6hA HEK293_TMG_6hB YEATS2 protein_coding protein_coding 13.28437 14.35669 14.56918 1.916384 0.3479937 0.02118233 3.608578 2.689085 4.64638981 1.3536662 0.71395652 0.7867415 0.27812500 0.21316667 0.320600000 0.10743333 8.544411e-01 9.250757e-11 FALSE TRUE
ENST00000432781 ENSG00000163872 HEK293_OSMI2_6hA HEK293_TMG_6hB YEATS2 protein_coding protein_coding 13.28437 14.35669 14.56918 1.916384 0.3479937 0.02118233 1.307970 1.176923 0.78507016 0.3303646 0.09296096 -0.5780722 0.10059167 0.08683333 0.054133333 -0.03270000 8.086021e-01 9.250757e-11 FALSE TRUE
ENST00000468850 ENSG00000163872 HEK293_OSMI2_6hA HEK293_TMG_6hB YEATS2 protein_coding retained_intron 13.28437 14.35669 14.56918 1.916384 0.3479937 0.02118233 1.614742 2.764158 0.02531831 0.7492665 0.02531831 -6.2954900 0.12558750 0.18643333 0.001666667 -0.18476667 9.250757e-11 9.250757e-11 FALSE FALSE
MSTRG.24145.2 ENSG00000163872 HEK293_OSMI2_6hA HEK293_TMG_6hB YEATS2 protein_coding   13.28437 14.35669 14.56918 1.916384 0.3479937 0.02118233 1.796990 2.971173 2.24751907 1.4278872 1.12879903 -0.4011418 0.12502917 0.18816667 0.152933333 -0.03523333 9.542413e-01 9.250757e-11 FALSE TRUE
MSTRG.24145.5 ENSG00000163872 HEK293_OSMI2_6hA HEK293_TMG_6hB YEATS2 protein_coding   13.28437 14.35669 14.56918 1.916384 0.3479937 0.02118233 0.327337 0.000000 0.73239845 0.0000000 0.73239845 6.2141218 0.02745417 0.00000000 0.051500000 0.05150000 8.997802e-01 9.250757e-11 FALSE TRUE
MSTRG.24145.6 ENSG00000163872 HEK293_OSMI2_6hA HEK293_TMG_6hB YEATS2 protein_coding   13.28437 14.35669 14.56918 1.916384 0.3479937 0.02118233 2.381235 3.311055 4.37882551 1.7231801 0.63311086 0.4021935 0.17016250 0.20356667 0.299133333 0.09556667 8.641052e-01 9.250757e-11 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000163872 E001 0.1779838 0.0370801625 4.731281e-01   3 183697797 183697805 9 + 0.122 0.000 -10.241
ENSG00000163872 E002 19.6657723 0.0016604050 8.683837e-01 9.350448e-01 3 183697806 183697993 188 + 1.317 1.320 0.012
ENSG00000163872 E003 0.3337900 0.0328927130 9.808613e-01   3 183698099 183698110 12 + 0.122 0.121 -0.010
ENSG00000163872 E004 0.5117739 0.0222724741 5.455667e-01   3 183698111 183698123 13 + 0.217 0.121 -1.012
ENSG00000163872 E005 1.5489257 0.0302325144 7.054351e-01 8.389858e-01 3 183698124 183698210 87 + 0.419 0.360 -0.332
ENSG00000163872 E006 48.2533559 0.0016398035 3.165550e-04 3.897225e-03 3 183715144 183715262 119 + 1.771 1.594 -0.600
ENSG00000163872 E007 54.9051864 0.0073835759 7.431975e-06 1.620596e-04 3 183717651 183717748 98 + 1.860 1.589 -0.919
ENSG00000163872 E008 56.8129787 0.0076572130 8.257547e-06 1.776665e-04 3 183718500 183718592 93 + 1.873 1.604 -0.912
ENSG00000163872 E009 104.1638779 0.0064759728 3.401821e-06 8.276610e-05 3 183721891 183722136 246 + 2.121 1.903 -0.730
ENSG00000163872 E010 76.4447606 0.0370475581 3.055096e-02 1.289943e-01 3 183724419 183724531 113 + 1.970 1.791 -0.604
ENSG00000163872 E011 94.6105988 0.0436850696 3.528391e-02 1.423316e-01 3 183728690 183728851 162 + 2.062 1.882 -0.606
ENSG00000163872 E012 76.3963934 0.0285773785 1.799439e-01 4.038939e-01 3 183736718 183736829 112 + 1.930 1.841 -0.300
ENSG00000163872 E013 47.3512060 0.0009440112 4.940630e-01 6.967317e-01 3 183747672 183747716 45 + 1.698 1.680 -0.061
ENSG00000163872 E014 99.7518406 0.0005146613 2.849464e-04 3.576530e-03 3 183752073 183752253 181 + 2.060 1.946 -0.380
ENSG00000163872 E015 12.1395515 0.0026082131 7.672133e-01 8.769340e-01 3 183754123 183754125 3 + 1.124 1.110 -0.049
ENSG00000163872 E016 128.3478859 0.0003273230 8.251528e-07 2.401130e-05 3 183754126 183754365 240 + 2.177 2.039 -0.463
ENSG00000163872 E017 94.3902478 0.0004898455 1.486786e-02 7.758321e-02 3 183756528 183756689 162 + 2.016 1.943 -0.244
ENSG00000163872 E018 70.1410560 0.0107177008 6.930680e-01 8.311247e-01 3 183758862 183758965 104 + 1.857 1.851 -0.021
ENSG00000163872 E019 76.4889365 0.0080254999 9.404851e-01 9.725364e-01 3 183761507 183761614 108 + 1.883 1.901 0.059
ENSG00000163872 E020 106.4570582 0.0052004309 8.482570e-01 9.239651e-01 3 183762097 183762279 183 + 2.028 2.038 0.035
ENSG00000163872 E021 142.5052361 0.0004163598 1.131345e-01 3.044022e-01 3 183772305 183772563 259 + 2.173 2.142 -0.104
ENSG00000163872 E022 93.1570351 0.0004311223 1.266391e-02 6.910519e-02 3 183773633 183773794 162 + 2.013 1.938 -0.251
ENSG00000163872 E023 29.0339130 0.0015009365 5.791894e-01 7.566013e-01 3 183775915 183775990 76 + 1.450 1.503 0.180
ENSG00000163872 E024 68.3529448 0.0035379318 5.791005e-01 7.565751e-01 3 183775991 183776123 133 + 1.823 1.868 0.153
ENSG00000163872 E025 125.1375590 0.0070709729 6.474266e-01 8.017729e-01 3 183777542 183777700 159 + 2.104 2.101 -0.012
ENSG00000163872 E026 134.7081895 0.0028875437 8.225836e-01 9.094833e-01 3 183786125 183786301 177 + 2.131 2.138 0.025
ENSG00000163872 E027 122.8915361 0.0040037895 5.152525e-01 7.118316e-01 3 183790797 183790980 184 + 2.102 2.087 -0.050
ENSG00000163872 E028 6.6217468 0.0215282647 7.392900e-02 2.326243e-01 3 183793116 183793486 371 + 0.743 0.998 0.982
ENSG00000163872 E029 71.1999895 0.0011803722 9.001044e-01 9.519205e-01 3 183797923 183797995 73 + 1.849 1.869 0.068
ENSG00000163872 E030 68.7685935 0.0038737258 7.012722e-01 8.364152e-01 3 183797996 183798051 56 + 1.826 1.858 0.106
ENSG00000163872 E031 74.2926995 0.0110124769 1.197907e-01 3.155367e-01 3 183798891 183798989 99 + 1.817 1.927 0.372
ENSG00000163872 E032 82.1040969 0.0021380871 2.099047e-01 4.417290e-01 3 183800466 183800568 103 + 1.884 1.953 0.232
ENSG00000163872 E033 2.6284051 0.0674050081 3.664028e-01 6.010282e-01 3 183800977 183801454 478 + 0.628 0.469 -0.740
ENSG00000163872 E034 69.8800068 0.0006496318 8.630483e-01 9.320323e-01 3 183801455 183801528 74 + 1.845 1.854 0.029
ENSG00000163872 E035 36.5985007 0.1455188498 1.102572e-01 2.994148e-01 3 183801529 183803255 1727 + 1.683 1.434 -0.854
ENSG00000163872 E036 67.3651712 0.0032589569 6.165121e-01 7.813904e-01 3 183803256 183803335 80 + 1.838 1.827 -0.039
ENSG00000163872 E037 12.3946827 0.0322075839 7.965146e-02 2.441281e-01 3 183803336 183803986 651 + 1.217 1.005 -0.766
ENSG00000163872 E038 123.5416884 0.0195464084 3.425031e-01 5.802332e-01 3 183803987 183804188 202 + 2.055 2.133 0.261
ENSG00000163872 E039 136.8036558 1.3057823671 4.868788e-01 6.918230e-01 3 183806866 183807092 227 + 2.033 2.222 0.631
ENSG00000163872 E040 0.8203656 0.4994654836 9.905974e-02   3 183808024 183808029 6 + 0.000 0.418 12.963
ENSG00000163872 E041 71.8039265 0.7947957600 3.321340e-01 5.710001e-01 3 183808030 183808104 75 + 1.721 1.966 0.825
ENSG00000163872 E042 1.6618501 0.4088631029 9.359335e-02 2.704053e-01 3 183808933 183809096 164 + 0.122 0.578 3.100
ENSG00000163872 E043 77.7282326 0.8014590608 2.935802e-01 5.342377e-01 3 183809097 183809170 74 + 1.731 2.013 0.949
ENSG00000163872 E044 2.6732689 0.5374633457 5.570595e-01 7.411809e-01 3 183809171 183809479 309 + 0.417 0.669 1.186
ENSG00000163872 E045 786.3881342 0.0006511315 9.074088e-20 2.564041e-17 3 183810475 183812877 2403 + 2.812 2.965 0.508