ENSG00000163812

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000296127 ENSG00000163812 HEK293_OSMI2_6hA HEK293_TMG_6hB ZDHHC3 protein_coding protein_coding 62.62488 70.82131 54.10278 3.232256 1.283955 -0.3884179 24.994284 25.379408 21.093664 3.3148413 0.8717146 -0.2667333 0.4000458 0.35550000 0.38960000 0.034100000 0.85424937 0.01486026 FALSE  
ENST00000339420 ENSG00000163812 HEK293_OSMI2_6hA HEK293_TMG_6hB ZDHHC3 protein_coding protein_coding 62.62488 70.82131 54.10278 3.232256 1.283955 -0.3884179 6.675330 9.551876 3.941649 0.5270569 0.4641607 -1.2748389 0.1040542 0.13520000 0.07253333 -0.062666667 0.01486026 0.01486026 FALSE  
ENST00000433512 ENSG00000163812 HEK293_OSMI2_6hA HEK293_TMG_6hB ZDHHC3 protein_coding protein_coding 62.62488 70.82131 54.10278 3.232256 1.283955 -0.3884179 8.069809 6.679709 11.175326 3.4620596 0.8523474 0.7415918 0.1244125 0.09726667 0.20713333 0.109866667 0.78483051 0.01486026    
MSTRG.22847.6 ENSG00000163812 HEK293_OSMI2_6hA HEK293_TMG_6hB ZDHHC3 protein_coding   62.62488 70.82131 54.10278 3.232256 1.283955 -0.3884179 5.995197 6.820531 4.999416 0.9745235 1.0262099 -0.4473552 0.1021875 0.09756667 0.09163333 -0.005933333 0.98130616 0.01486026 TRUE  
MSTRG.22847.9 ENSG00000163812 HEK293_OSMI2_6hA HEK293_TMG_6hB ZDHHC3 protein_coding   62.62488 70.82131 54.10278 3.232256 1.283955 -0.3884179 12.514470 16.839060 9.475194 2.8112990 0.6002941 -0.8289189 0.1970792 0.23656667 0.17566667 -0.060900000 0.63583977 0.01486026 TRUE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000163812 E001 0.3503582 0.0287123958 6.958002e-01   3 44915257 44915260 4 - 0.154 0.095 -0.803
ENSG00000163812 E002 573.0466621 0.0015392454 7.829642e-12 6.850352e-10 3 44915261 44917408 2148 - 2.634 2.790 0.521
ENSG00000163812 E003 136.5342300 0.0024342311 9.679308e-03 5.674431e-02 3 44917409 44917838 430 - 2.056 2.152 0.321
ENSG00000163812 E004 118.3101431 0.0004336335 5.232986e-01 7.173305e-01 3 44917839 44918143 305 - 2.048 2.060 0.040
ENSG00000163812 E005 49.2497650 0.0330620453 5.805023e-01 7.575006e-01 3 44918144 44918792 649 - 1.630 1.710 0.269
ENSG00000163812 E006 101.8902889 0.0143186635 2.564019e-01 4.951720e-01 3 44918793 44919977 1185 - 1.935 2.023 0.293
ENSG00000163812 E007 47.9975602 0.0008986232 1.952910e-01 4.237108e-01 3 44919978 44920337 360 - 1.627 1.688 0.207
ENSG00000163812 E008 338.7570643 0.0123639074 6.242913e-02 2.082070e-01 3 44920338 44924845 4508 - 2.572 2.475 -0.324
ENSG00000163812 E009 908.7724809 0.0067114687 3.111154e-02 1.306891e-01 3 44924846 44926080 1235 - 2.986 2.912 -0.246
ENSG00000163812 E010 529.3465288 0.0013431658 2.928929e-04 3.657888e-03 3 44926081 44926522 442 - 2.756 2.670 -0.285
ENSG00000163812 E011 264.9692636 0.0016313090 3.899644e-02 1.521747e-01 3 44926523 44926612 90 - 2.444 2.377 -0.223
ENSG00000163812 E012 538.8141502 0.0021509395 4.733388e-01 6.823555e-01 3 44926613 44926847 235 - 2.727 2.703 -0.081
ENSG00000163812 E013 487.8312625 0.0016078591 6.515895e-01 8.045443e-01 3 44929306 44929436 131 - 2.680 2.662 -0.060
ENSG00000163812 E014 54.7999100 0.0028791323 1.172210e-01 3.111883e-01 3 44932907 44932990 84 - 1.786 1.692 -0.319
ENSG00000163812 E015 278.6859727 0.0002577757 1.251266e-01 3.239557e-01 3 44933118 44933137 20 - 2.454 2.410 -0.147
ENSG00000163812 E016 329.5016392 0.0006338515 7.568517e-01 8.707717e-01 3 44933138 44933187 50 - 2.509 2.493 -0.053
ENSG00000163812 E017 248.9510389 0.0002410857 6.228765e-01 7.857581e-01 3 44933188 44933199 12 - 2.391 2.369 -0.072
ENSG00000163812 E018 1.7850835 0.2708724601 1.612679e-01 3.786447e-01 3 44933200 44933449 250 - 0.153 0.522 2.462
ENSG00000163812 E019 417.0758979 0.0007420784 9.366855e-01 9.705442e-01 3 44933888 44933984 97 - 2.604 2.598 -0.023
ENSG00000163812 E020 486.2033954 0.0022525857 1.095480e-01 2.983386e-01 3 44945168 44945292 125 - 2.645 2.681 0.122
ENSG00000163812 E021 0.5474829 0.0264677919 2.029322e-01   3 44945293 44945329 37 - 0.000 0.239 9.902
ENSG00000163812 E022 3.8579821 0.0572508785 7.371983e-01 8.587112e-01 3 44958588 44958685 98 - 0.685 0.630 -0.234
ENSG00000163812 E023 9.8354572 0.0036359386 2.565531e-01 4.953150e-01 3 44959127 44959130 4 - 1.097 0.969 -0.471
ENSG00000163812 E024 713.4811447 0.0014671513 9.399103e-02 2.711346e-01 3 44959131 44959460 330 - 2.815 2.844 0.098
ENSG00000163812 E025 1.2566419 0.0646372683 3.126469e-01   3 44961555 44961646 92 - 0.434 0.241 -1.209
ENSG00000163812 E026 0.1779838 0.0346419656 2.906478e-01   3 44969609 44969931 323 - 0.154 0.000 -9.954
ENSG00000163812 E027 219.7435843 0.0090219889 1.279900e-03 1.200930e-02 3 44975933 44976185 253 - 2.213 2.376 0.543