ENSG00000163682

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295955 ENSG00000163682 HEK293_OSMI2_6hA HEK293_TMG_6hB RPL9 protein_coding protein_coding 1532.979 218.3445 1856.532 41.79943 100.1355 3.087874 1457.53756 186.03006 1766.58472 39.901250 97.4920158 3.247286 0.93034583 0.8442333 0.95143333 0.1072 4.658982e-06 3.386841e-08 FALSE TRUE
ENST00000449470 ENSG00000163682 HEK293_OSMI2_6hA HEK293_TMG_6hB RPL9 protein_coding protein_coding 1532.979 218.3445 1856.532 41.79943 100.1355 3.087874 46.07715 20.98143 44.14455 1.631845 0.6594781 1.072761 0.04407083 0.1013667 0.02386667 -0.0775 3.386841e-08 3.386841e-08 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000163682 E001 0.8333724 6.307304e-01 2.505601e-01   4 39449433 39449471 39 - 0.130 0.454 2.405
ENSG00000163682 E002 0.7664957 1.916754e-02 1.249629e-01   4 39452302 39452389 88 - 0.134 0.434 2.245
ENSG00000163682 E003 69.9881795 7.042139e-04 6.833750e-05 1.087406e-03 4 39452587 39454120 1534 - 1.637 1.870 0.788
ENSG00000163682 E004 7.4396257 3.851056e-03 6.074104e-01 7.751557e-01 4 39454121 39454123 3 - 0.757 0.847 0.352
ENSG00000163682 E005 11.0416940 4.081000e-03 3.507324e-02 1.417649e-01 4 39454124 39454131 8 - 0.870 1.144 1.012
ENSG00000163682 E006 63.3923266 5.852180e-04 4.995211e-02 1.795686e-01 4 39454132 39454136 5 - 1.645 1.516 -0.440
ENSG00000163682 E007 78.6942360 5.700596e-04 1.085705e-01 2.967031e-01 4 39454137 39454138 2 - 1.734 1.644 -0.307
ENSG00000163682 E008 937.0925264 7.385232e-04 6.888934e-03 4.413383e-02 4 39454139 39454170 32 - 2.799 2.751 -0.159
ENSG00000163682 E009 1612.2293628 9.108560e-04 4.607755e-02 1.702203e-01 4 39454171 39454225 55 - 3.032 3.006 -0.088
ENSG00000163682 E010 1814.4943079 5.585904e-04 5.062301e-01 7.051046e-01 4 39454533 39454561 29 - 3.077 3.100 0.078
ENSG00000163682 E011 3336.0733778 6.176492e-05 4.645039e-06 1.079855e-04 4 39454562 39454649 88 - 3.348 3.314 -0.112
ENSG00000163682 E012 3912.3843949 1.267907e-04 1.137211e-01 3.053329e-01 4 39454864 39454929 66 - 3.413 3.410 -0.013
ENSG00000163682 E013 3059.1761911 2.434854e-04 3.916838e-04 4.650883e-03 4 39454930 39454944 15 - 3.310 3.280 -0.101
ENSG00000163682 E014 98.2938773 2.994835e-02 5.390252e-05 8.882957e-04 4 39454945 39455276 332 - 1.747 2.147 1.343
ENSG00000163682 E015 163.1683775 1.615966e-02 4.279103e-06 1.006078e-04 4 39455811 39456327 517 - 1.978 2.320 1.143
ENSG00000163682 E016 60.6558919 2.168255e-02 9.169942e-04 9.236460e-03 4 39456328 39456405 78 - 1.563 1.870 1.043
ENSG00000163682 E017 5252.4931700 9.949569e-05 9.976044e-09 4.698175e-07 4 39456406 39456538 133 - 3.545 3.510 -0.119
ENSG00000163682 E018 16.9274191 6.548742e-02 3.957897e-02 1.536829e-01 4 39456539 39457125 587 - 1.026 1.358 1.181
ENSG00000163682 E019 6.4224993 1.157512e-01 1.309974e-02 7.085509e-02 4 39457355 39457375 21 - 0.615 1.121 1.968
ENSG00000163682 E020 14.9927570 2.628948e-03 1.532534e-03 1.383402e-02 4 39457376 39457585 210 - 0.971 1.318 1.247
ENSG00000163682 E021 2705.2819326 5.749638e-05 6.396999e-05 1.028261e-03 4 39457586 39457596 11 - 3.257 3.225 -0.105
ENSG00000163682 E022 4977.5692140 5.006770e-05 8.878572e-02 2.615413e-01 4 39457597 39457681 85 - 3.518 3.516 -0.007
ENSG00000163682 E023 6.2585175 4.633037e-02 1.297536e-01 3.314480e-01 4 39457805 39457923 119 - 0.668 0.938 1.068
ENSG00000163682 E024 8.2943156 1.051850e-02 2.026347e-01 4.328652e-01 4 39457924 39458193 270 - 0.785 0.981 0.752
ENSG00000163682 E025 5202.2719089 3.150091e-05 2.971017e-01 5.375556e-01 4 39458194 39458309 116 - 3.537 3.540 0.010
ENSG00000163682 E026 9.6861716 3.915847e-02 7.297702e-02 2.307897e-01 4 39458310 39458393 84 - 0.905 0.552 -1.458
ENSG00000163682 E027 3243.8143604 5.087808e-05 2.637984e-03 2.120062e-02 4 39458394 39458440 47 - 3.327 3.365 0.127
ENSG00000163682 E028 118.1041880 4.630786e-03 3.025935e-31 2.690437e-28 4 39458441 39458441 1 - 1.770 2.343 1.921
ENSG00000163682 E029 280.0970462 5.419535e-03 5.738632e-48 1.624253e-44 4 39458442 39458598 157 - 2.120 2.751 2.103
ENSG00000163682 E030 264.7584666 1.284866e-02 1.676638e-23 7.300814e-21 4 39458599 39458890 292 - 2.102 2.719 2.058
ENSG00000163682 E031 1555.8657803 6.495001e-05 1.250816e-01 3.238915e-01 4 39458891 39458931 41 - 3.014 3.004 -0.035