ENSG00000163681

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000449503 ENSG00000163681 HEK293_OSMI2_6hA HEK293_TMG_6hB SLMAP protein_coding protein_coding 15.78026 8.040773 28.07163 2.022342 1.535137 1.802427 0.70632488 0.4103105 1.1882267 0.41031049 0.6060312 1.5113736 0.05524167 0.04133333 0.04020000 -0.001133333 8.277031e-01 1.367021e-05 FALSE TRUE
ENST00000460223 ENSG00000163681 HEK293_OSMI2_6hA HEK293_TMG_6hB SLMAP protein_coding protein_coding 15.78026 8.040773 28.07163 2.022342 1.535137 1.802427 0.32935471 0.5464300 0.2998294 0.33936525 0.2998294 -0.8447262 0.04105000 0.07850000 0.01020000 -0.068300000 5.887349e-01 1.367021e-05   FALSE
ENST00000494088 ENSG00000163681 HEK293_OSMI2_6hA HEK293_TMG_6hB SLMAP protein_coding protein_coding 15.78026 8.040773 28.07163 2.022342 1.535137 1.802427 3.29615824 1.5845521 5.0080973 0.50679453 1.7649471 1.6539892 0.20097500 0.20130000 0.17283333 -0.028466667 9.228579e-01 1.367021e-05 FALSE TRUE
ENST00000497084 ENSG00000163681 HEK293_OSMI2_6hA HEK293_TMG_6hB SLMAP protein_coding retained_intron 15.78026 8.040773 28.07163 2.022342 1.535137 1.802427 0.68779362 0.2757006 1.2178425 0.07672898 0.2769083 2.1035494 0.05211250 0.04673333 0.04396667 -0.002766667 9.818698e-01 1.367021e-05 FALSE FALSE
ENST00000671191 ENSG00000163681 HEK293_OSMI2_6hA HEK293_TMG_6hB SLMAP protein_coding protein_coding 15.78026 8.040773 28.07163 2.022342 1.535137 1.802427 1.30506210 0.4246974 1.2381778 0.21401583 0.3159292 1.5217401 0.08240833 0.04226667 0.04373333 0.001466667 9.678641e-01 1.367021e-05 FALSE TRUE
MSTRG.23147.14 ENSG00000163681 HEK293_OSMI2_6hA HEK293_TMG_6hB SLMAP protein_coding   15.78026 8.040773 28.07163 2.022342 1.535137 1.802427 0.97170183 0.1332526 3.2619408 0.13325265 0.8188244 4.5135129 0.04375417 0.01306667 0.11853333 0.105466667 1.548482e-01 1.367021e-05 FALSE TRUE
MSTRG.23147.17 ENSG00000163681 HEK293_OSMI2_6hA HEK293_TMG_6hB SLMAP protein_coding   15.78026 8.040773 28.07163 2.022342 1.535137 1.802427 0.35693391 0.0000000 1.6280090 0.00000000 0.3288729 7.3557995 0.01501667 0.00000000 0.05883333 0.058833333 1.367021e-05 1.367021e-05 FALSE TRUE
MSTRG.23147.3 ENSG00000163681 HEK293_OSMI2_6hA HEK293_TMG_6hB SLMAP protein_coding   15.78026 8.040773 28.07163 2.022342 1.535137 1.802427 1.60767917 1.1433872 1.3136696 0.75163482 1.3136696 0.1986661 0.10988750 0.12406667 0.04476667 -0.079300000 3.656570e-01 1.367021e-05 FALSE TRUE
MSTRG.23147.4 ENSG00000163681 HEK293_OSMI2_6hA HEK293_TMG_6hB SLMAP protein_coding   15.78026 8.040773 28.07163 2.022342 1.535137 1.802427 1.90519239 0.8631386 4.4640430 0.67855739 0.4272797 2.3572966 0.08361250 0.10433333 0.15910000 0.054766667 7.963009e-01 1.367021e-05 TRUE TRUE
MSTRG.23147.6 ENSG00000163681 HEK293_OSMI2_6hA HEK293_TMG_6hB SLMAP protein_coding   15.78026 8.040773 28.07163 2.022342 1.535137 1.802427 1.67327540 0.5161383 2.8177122 0.18860536 0.4504276 2.4261214 0.07737083 0.06010000 0.10286667 0.042766667 6.216617e-01 1.367021e-05 FALSE TRUE
MSTRG.23147.8 ENSG00000163681 HEK293_OSMI2_6hA HEK293_TMG_6hB SLMAP protein_coding   15.78026 8.040773 28.07163 2.022342 1.535137 1.802427 0.06923511 0.2616753 0.0000000 0.17293090 0.0000000 -4.7638113 0.01580000 0.05563333 0.00000000 -0.055633333 2.825972e-01 1.367021e-05 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000163681 E001 0.5339515 0.8968028333 8.976678e-01   3 57755450 57755485 36 + 0.201 0.000 -9.215
ENSG00000163681 E002 1.3628298 0.0132116030 5.927776e-01   3 57756230 57756263 34 + 0.325 0.428 0.594
ENSG00000163681 E003 1.7789673 0.0324349950 5.516919e-01 0.7374724973 3 57756264 57756273 10 + 0.394 0.509 0.592
ENSG00000163681 E004 3.5103391 0.0124187359 3.850799e-01 0.6165738732 3 57756274 57756281 8 + 0.655 0.510 -0.654
ENSG00000163681 E005 9.3169432 0.0232558024 8.308638e-01 0.9142771020 3 57756282 57756308 27 + 0.960 0.996 0.134
ENSG00000163681 E006 24.2404647 0.0085712551 2.362702e-01 0.4722706900 3 57756309 57756342 34 + 1.314 1.428 0.394
ENSG00000163681 E007 32.9734170 0.0046206289 4.273963e-02 0.1618827016 3 57756548 57756596 49 + 1.431 1.585 0.531
ENSG00000163681 E008 55.0188047 0.0122523588 3.429493e-04 0.0041668945 3 57756597 57756931 335 + 1.604 1.877 0.924
ENSG00000163681 E009 19.3300526 0.0021053961 1.983581e-05 0.0003795579 3 57756932 57757012 81 + 1.134 1.487 1.234
ENSG00000163681 E010 19.6687186 0.0020421671 1.332711e-01 0.3369295782 3 57757013 57757067 55 + 1.225 1.359 0.470
ENSG00000163681 E011 25.6467215 0.0124515470 2.321359e-01 0.4676660862 3 57757068 57757119 52 + 1.343 1.453 0.381
ENSG00000163681 E012 49.3319886 0.0068700485 5.259432e-01 0.7192171280 3 57757120 57757235 116 + 1.634 1.680 0.158
ENSG00000163681 E013 59.6610147 0.0100736565 1.169015e-01 0.3106672364 3 57757236 57757300 65 + 1.749 1.629 -0.406
ENSG00000163681 E014 83.3880110 0.0005248449 3.109254e-04 0.0038407994 3 57757301 57757446 146 + 1.903 1.739 -0.552
ENSG00000163681 E015 65.5955044 0.0037991808 3.193097e-03 0.0245656149 3 57757447 57757553 107 + 1.806 1.633 -0.587
ENSG00000163681 E016 28.2261799 0.0046657777 1.679356e-01 0.3878387387 3 57757554 57757557 4 + 1.436 1.326 -0.382
ENSG00000163681 E017 109.5131204 0.0066952595 5.191556e-02 0.1842173047 3 57757558 57757849 292 + 2.012 1.903 -0.368
ENSG00000163681 E018 0.0000000       3 57820613 57820705 93 +      
ENSG00000163681 E019 80.2057610 0.0006337738 2.083021e-03 0.0176202866 3 57831383 57831530 148 + 1.883 1.743 -0.471
ENSG00000163681 E020 1.8919797 0.0100833189 4.832974e-01 0.6892862746 3 57831531 57831536 6 + 0.456 0.327 -0.728
ENSG00000163681 E021 60.6926183 0.0006209266 5.383616e-01 0.7279039267 3 57841299 57841371 73 + 1.736 1.711 -0.083
ENSG00000163681 E022 50.2421400 0.0008864858 2.432186e-01 0.4802804148 3 57847197 57847233 37 + 1.629 1.702 0.246
ENSG00000163681 E023 62.3190966 0.0007155006 2.918303e-01 0.5325024741 3 57849754 57849816 63 + 1.724 1.785 0.206
ENSG00000163681 E024 0.1426347 0.0331010345 1.000000e+00   3 57856560 57856648 89 + 0.074 0.000 -11.224
ENSG00000163681 E025 82.2758897 0.0004527582 6.909572e-01 0.8296808226 3 57857733 57857828 96 + 1.865 1.855 -0.032
ENSG00000163681 E026 88.7159979 0.0004546201 1.222355e-01 0.3194041498 3 57858088 57858159 72 + 1.908 1.848 -0.203
ENSG00000163681 E027 77.7109948 0.0005252044 1.073647e-01 0.2946161389 3 57860699 57860759 61 + 1.853 1.785 -0.230
ENSG00000163681 E028 85.7250245 0.0061888312 4.195928e-02 0.1598310717 3 57860760 57860839 80 + 1.904 1.788 -0.390
ENSG00000163681 E029 44.4347052 0.0055690723 7.625804e-02 0.2372599490 3 57861949 57861953 5 + 1.623 1.502 -0.412
ENSG00000163681 E030 63.5413104 0.0130473415 1.663514e-01 0.3857015084 3 57861954 57861999 46 + 1.771 1.668 -0.348
ENSG00000163681 E031 74.6302030 0.0095578534 8.542192e-02 0.2553800349 3 57862000 57862086 87 + 1.843 1.730 -0.382
ENSG00000163681 E032 44.8059398 0.0046302617 9.888122e-02 0.2798251083 3 57864548 57864556 9 + 1.625 1.517 -0.367
ENSG00000163681 E033 48.0310484 0.0010059803 2.019363e-01 0.4320051118 3 57864557 57864572 16 + 1.648 1.580 -0.232
ENSG00000163681 E034 42.7961830 0.0008799362 8.198637e-01 0.9080052654 3 57864573 57864585 13 + 1.585 1.580 -0.020
ENSG00000163681 E035 82.9521044 0.0004946468 4.182121e-01 0.6422858084 3 57864586 57864716 131 + 1.873 1.845 -0.096
ENSG00000163681 E036 37.0236777 0.0010105833 2.092101e-01 0.4409399639 3 57864807 57864857 51 + 1.539 1.463 -0.262
ENSG00000163681 E037 13.4366648 0.0029285909 3.457822e-02 0.1404450999 3 57865242 57865292 51 + 1.152 0.918 -0.856
ENSG00000163681 E038 26.7461760 0.0017648399 6.240612e-01 0.7866624149 3 57871636 57871698 63 + 1.391 1.359 -0.109
ENSG00000163681 E039 0.2735028 0.0274424043 4.224133e-01   3 57883961 57884026 66 + 0.074 0.193 1.593
ENSG00000163681 E040 0.2922838 0.0254828469 4.227275e-01   3 57889991 57890040 50 + 0.074 0.193 1.592
ENSG00000163681 E041 46.4009932 0.0008982076 9.949407e-01 0.9990410588 3 57890041 57890045 5 + 1.620 1.628 0.028
ENSG00000163681 E042 48.7215467 0.0009163636 9.906335e-01 0.9970410682 3 57890046 57890047 2 + 1.640 1.650 0.033
ENSG00000163681 E043 52.0118228 0.0008273384 9.101124e-01 0.9572111386 3 57890048 57890056 9 + 1.669 1.671 0.008
ENSG00000163681 E044 68.6636243 0.0006091900 5.049501e-01 0.7042835135 3 57890057 57890100 44 + 1.793 1.769 -0.082
ENSG00000163681 E045 1.0923477 0.2844812143 1.960135e-01   3 57890101 57891206 1106 + 0.360 0.000 -13.251
ENSG00000163681 E046 0.3206185 0.0274424043 7.776930e-01   3 57896239 57896246 8 + 0.137 0.000 -12.227
ENSG00000163681 E047 2.8865278 0.0148913438 9.432749e-01 0.9739756724 3 57896247 57896339 93 + 0.556 0.579 0.102
ENSG00000163681 E048 1.7078388 0.0110710046 5.774076e-01 0.7553783094 3 57896340 57896340 1 + 0.427 0.326 -0.578
ENSG00000163681 E049 1.8504735 0.0104388763 4.775739e-01 0.6854549633 3 57896341 57896371 31 + 0.456 0.326 -0.729
ENSG00000163681 E050 0.6129023 0.0189700218 1.000000e+00   3 57896372 57896510 139 + 0.192 0.193 0.008
ENSG00000163681 E051 46.8778298 0.0007484715 1.326493e-01 0.3359656853 3 57896511 57896518 8 + 1.642 1.560 -0.281
ENSG00000163681 E052 74.8947699 0.0005129484 2.529635e-01 0.4912073159 3 57896519 57896591 73 + 1.835 1.789 -0.155
ENSG00000163681 E053 86.9329282 0.0004788281 3.242968e-01 0.5635548739 3 57896873 57896932 60 + 1.896 1.862 -0.117
ENSG00000163681 E054 2.3902515 0.3858158006 5.820312e-01 0.7583903525 3 57896933 57902145 5213 + 0.433 0.594 0.773
ENSG00000163681 E055 116.5512258 0.0035834700 6.180980e-01 0.7825084924 3 57907884 57908006 123 + 2.018 2.007 -0.037
ENSG00000163681 E056 0.8211734 0.6749037491 3.624747e-01   3 57908168 57908227 60 + 0.136 0.437 2.243
ENSG00000163681 E057 80.7465911 0.0036959680 2.539610e-01 0.4923350814 3 57909076 57909150 75 + 1.840 1.907 0.227
ENSG00000163681 E058 0.4868358 0.2419197180 7.692668e-01   3 57912295 57912380 86 + 0.139 0.191 0.549
ENSG00000163681 E059 111.0724330 0.0004108199 5.588995e-01 0.7424610057 3 57912381 57912503 123 + 1.984 2.015 0.103
ENSG00000163681 E060 160.6567555 0.0005103549 4.169502e-01 0.6413512400 3 57912504 57912701 198 + 2.154 2.135 -0.062
ENSG00000163681 E061 132.6003120 0.0004673177 3.361306e-01 0.5745848894 3 57913158 57913275 118 + 2.073 2.047 -0.089
ENSG00000163681 E062 88.7094602 0.0023964972 6.269187e-01 0.7884677201 3 57916906 57916964 59 + 1.884 1.917 0.111
ENSG00000163681 E063 46.2218952 0.0059587391 4.941201e-01 0.6967622942 3 57916965 57916980 16 + 1.596 1.656 0.205
ENSG00000163681 E064 98.0543642 0.0005287648 8.922985e-01 0.9477672334 3 57916981 57917077 97 + 1.935 1.938 0.010
ENSG00000163681 E065 8.8380585 0.0033612090 2.227148e-03 0.0185721034 3 57917078 57918480 1403 + 0.830 1.176 1.283
ENSG00000163681 E066 124.6760645 0.0004788467 7.349324e-01 0.8572071107 3 57922889 57923023 135 + 2.037 2.058 0.070
ENSG00000163681 E067 90.0469715 0.0004761982 3.667850e-02 0.1460252626 3 57925845 57925934 90 + 1.876 1.971 0.317
ENSG00000163681 E068 7.7844901 0.0739310297 6.943243e-01 0.8319131906 3 57925935 57926290 356 + 0.876 0.921 0.170
ENSG00000163681 E069 114.6560827 0.0004024609 2.303989e-03 0.0190779782 3 57927296 57927513 218 + 1.972 2.091 0.397
ENSG00000163681 E070 483.2596309 0.0030755525 3.272312e-05 0.0005809868 3 57927514 57930003 2490 + 2.589 2.713 0.412
ENSG00000163681 E071 0.1308682 0.0326491905 1.519404e-01   3 57931659 57931691 33 + 0.000 0.193 12.946