ENSG00000163644

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295908 ENSG00000163644 HEK293_OSMI2_6hA HEK293_TMG_6hB PPM1K protein_coding protein_coding 4.840524 1.659703 10.07894 0.1919324 0.8330047 2.59511 0.311737 0.0000000 1.283427 0.00000000 0.2169223 7.015055 0.0379750 0.0000000 0.1323000 0.1323000 0.0009925615 0.0009925615 FALSE TRUE
ENST00000508256 ENSG00000163644 HEK293_OSMI2_6hA HEK293_TMG_6hB PPM1K protein_coding protein_coding 4.840524 1.659703 10.07894 0.1919324 0.8330047 2.59511 1.415830 0.2306351 3.527486 0.05865934 0.4497440 3.877805 0.2209958 0.1410333 0.3518667 0.2108333 0.0779604933 0.0009925615 FALSE TRUE
ENST00000608933 ENSG00000163644 HEK293_OSMI2_6hA HEK293_TMG_6hB PPM1K protein_coding protein_coding 4.840524 1.659703 10.07894 0.1919324 0.8330047 2.59511 2.490939 1.2923249 4.478421 0.22287512 0.8757376 1.785118 0.6106333 0.7696667 0.4394333 -0.3302333 0.1038286436 0.0009925615 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000163644 E001 242.9406168 1.431476590 0.251592857 0.48962923 4 88257620 88261870 4251 - 2.126 2.609 1.611
ENSG00000163644 E002 65.3494053 0.693658271 0.421261650 0.64458506 4 88261871 88262519 649 - 1.630 1.884 0.858
ENSG00000163644 E003 18.1708303 0.444923664 0.927376199 0.96575078 4 88262520 88262521 2 - 1.149 1.135 -0.049
ENSG00000163644 E004 22.8340468 0.451263117 0.885288448 0.94410643 4 88262522 88262576 55 - 1.234 1.275 0.145
ENSG00000163644 E005 38.3774141 0.529323087 0.623812757 0.78647926 4 88262577 88262726 150 - 1.433 1.561 0.439
ENSG00000163644 E006 35.0648596 0.503945757 0.570301139 0.75046880 4 88265001 88265135 135 - 1.391 1.543 0.525
ENSG00000163644 E007 46.5424416 0.031615587 0.027431719 0.11959993 4 88268190 88268321 132 - 1.535 1.546 0.039
ENSG00000163644 E008 25.2345004 0.083934689 0.113022768 0.30420099 4 88268322 88268334 13 - 1.280 1.279 -0.005
ENSG00000163644 E009 24.7221064 0.077271794 0.121106521 0.31762480 4 88268741 88268749 9 - 1.271 1.278 0.023
ENSG00000163644 E010 25.8506608 0.074904946 0.098956209 0.27997202 4 88268750 88268761 12 - 1.291 1.292 0.004
ENSG00000163644 E011 45.6478995 0.103999044 0.077055341 0.23892889 4 88268762 88268906 145 - 1.529 1.511 -0.062
ENSG00000163644 E012 3.1263737 0.450801082 0.639767605 0.79677362 4 88271000 88271189 190 - 0.425 0.778 1.589
ENSG00000163644 E013 1.3333798 0.013966728 0.086130957   4 88274924 88275144 221 - 0.187 0.613 2.530
ENSG00000163644 E014 0.5365243 0.023689020 0.100437663   4 88275145 88275204 60 - 0.055 0.407 3.531
ENSG00000163644 E015 10.3445537 0.150501720 0.248746476 0.48650090 4 88275205 88277142 1938 - 0.924 0.911 -0.049
ENSG00000163644 E016 32.9390360 0.100593531 0.077538645 0.23992415 4 88277143 88277243 101 - 1.393 1.366 -0.096
ENSG00000163644 E017 5.5541064 0.281146781 0.938729997 0.97167519 4 88277244 88278143 900 - 0.653 0.870 0.873
ENSG00000163644 E018 18.4412158 0.161203570 0.066561241 0.21731898 4 88278144 88278192 49 - 1.170 1.020 -0.543
ENSG00000163644 E019 38.9000227 0.112680203 0.006774441 0.04358613 4 88278193 88278535 343 - 1.488 1.267 -0.765
ENSG00000163644 E020 10.3431175 0.099604102 0.054109479 0.18933579 4 88278536 88278566 31 - 0.948 0.802 -0.561
ENSG00000163644 E021 12.8414008 0.002865802 0.001427203 0.01309199 4 88278567 88278642 76 - 1.044 0.808 -0.892
ENSG00000163644 E022 2.6632770 0.232041877 0.799702776 0.89619440 4 88278643 88279700 1058 - 0.418 0.679 1.223
ENSG00000163644 E023 1.3545613 0.524136931 0.334730049   4 88283775 88284261 487 - 0.225 0.535 1.843
ENSG00000163644 E024 22.1538195 0.002189148 0.038353323 0.15050160 4 88284406 88284769 364 - 1.236 1.237 0.004