ENSG00000163629

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000316707 ENSG00000163629 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPN13 protein_coding protein_coding 10.44179 3.208037 17.72325 0.6259309 0.4168677 2.462204 1.3074153 0.5801484 2.6148135 0.30934276 0.2670249 2.1530653 0.20774167 0.1543333 0.14836667 -0.005966667 9.511502e-01 1.190112e-07 FALSE TRUE
ENST00000411767 ENSG00000163629 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPN13 protein_coding protein_coding 10.44179 3.208037 17.72325 0.6259309 0.4168677 2.462204 0.9164331 0.1675710 0.0000000 0.16757097 0.0000000 -4.1503239 0.06559583 0.0466000 0.00000000 -0.046600000 6.637532e-01 1.190112e-07 FALSE TRUE
ENST00000427191 ENSG00000163629 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPN13 protein_coding protein_coding 10.44179 3.208037 17.72325 0.6259309 0.4168677 2.462204 3.4045151 0.2496409 8.1473687 0.24964092 0.6420371 4.9735142 0.20567083 0.1258667 0.45926667 0.333400000 2.276074e-01 1.190112e-07 FALSE TRUE
ENST00000436978 ENSG00000163629 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPN13 protein_coding protein_coding 10.44179 3.208037 17.72325 0.6259309 0.4168677 2.462204 0.3310132 0.4313773 0.0000000 0.34602165 0.0000000 -5.4639407 0.04478750 0.1219000 0.00000000 -0.121900000 9.573749e-02 1.190112e-07 FALSE TRUE
ENST00000511467 ENSG00000163629 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPN13 protein_coding protein_coding 10.44179 3.208037 17.72325 0.6259309 0.4168677 2.462204 1.4197444 0.0000000 3.2416506 0.00000000 0.5787525 8.3450284 0.08302917 0.0000000 0.18310000 0.183100000 1.190112e-07 1.190112e-07 FALSE TRUE
MSTRG.25168.5 ENSG00000163629 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPN13 protein_coding   10.44179 3.208037 17.72325 0.6259309 0.4168677 2.462204 2.1269725 0.7943525 3.0804894 0.04932458 0.4680864 1.9419354 0.21103333 0.2651667 0.17290000 -0.092266667 5.521392e-01 1.190112e-07 FALSE TRUE
MSTRG.25168.6 ENSG00000163629 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPN13 protein_coding   10.44179 3.208037 17.72325 0.6259309 0.4168677 2.462204 0.0988050 0.1840304 0.2487755 0.09217070 0.2487755 0.4154182 0.01295417 0.0699000 0.01376667 -0.056133333 5.747193e-01 1.190112e-07 FALSE TRUE
MSTRG.25168.7 ENSG00000163629 HEK293_OSMI2_6hA HEK293_TMG_6hB PTPN13 protein_coding   10.44179 3.208037 17.72325 0.6259309 0.4168677 2.462204 0.4940373 0.7473603 0.1113752 0.37658649 0.1113752 -2.6415060 0.13832500 0.1971667 0.00610000 -0.191066667 3.582351e-01 1.190112e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000163629 E001 0.1614157 0.0342982223 1.000000e+00   4 86594315 86594316 2 + 0.058 0.000 -7.210
ENSG00000163629 E002 21.1282474 0.7901094360 5.811830e-01 7.579229e-01 4 86594317 86594473 157 + 1.212 1.291 0.279
ENSG00000163629 E003 30.2385463 0.3060135121 6.760578e-01 8.202273e-01 4 86594474 86594731 258 + 1.360 1.445 0.297
ENSG00000163629 E004 12.1895748 0.0037473391 9.774574e-01 9.904871e-01 4 86594732 86594789 58 + 1.007 1.048 0.152
ENSG00000163629 E005 0.0000000       4 86595693 86595786 94 +      
ENSG00000163629 E006 25.5276681 0.0017013495 4.274368e-02 1.618944e-01 4 86635252 86635371 120 + 1.326 1.171 -0.547
ENSG00000163629 E007 55.2086928 0.0007245494 7.377794e-04 7.764263e-03 4 86672365 86672543 179 + 1.656 1.468 -0.645
ENSG00000163629 E008 44.1149762 0.0008327396 6.980901e-03 4.454823e-02 4 86686710 86686775 66 + 1.558 1.398 -0.552
ENSG00000163629 E009 63.3673939 0.0062114667 2.197677e-04 2.890236e-03 4 86689005 86689190 186 + 1.720 1.477 -0.827
ENSG00000163629 E010 1.8252049 0.0462621516 4.702551e-02 1.726113e-01 4 86689620 86690303 684 + 0.270 0.666 2.075
ENSG00000163629 E011 40.9234833 0.0102812650 6.540756e-04 7.043479e-03 4 86693587 86693674 88 + 1.541 1.247 -1.016
ENSG00000163629 E012 50.8607468 0.0051167183 2.969674e-07 9.771731e-06 4 86701241 86701434 194 + 1.639 1.230 -1.413
ENSG00000163629 E013 84.8022854 0.0005063223 2.847920e-08 1.205490e-06 4 86701435 86701801 367 + 1.847 1.564 -0.958
ENSG00000163629 E014 51.4209665 0.0009823969 1.067334e-07 3.930134e-06 4 86716530 86716625 96 + 1.644 1.266 -1.301
ENSG00000163629 E015 52.5523639 0.0015947279 6.434648e-06 1.433116e-04 4 86717024 86717117 94 + 1.646 1.344 -1.038
ENSG00000163629 E016 86.7994281 0.0023008195 1.818072e-05 3.523341e-04 4 86722212 86722434 223 + 1.852 1.635 -0.734
ENSG00000163629 E017 56.3078549 0.0048298230 1.807281e-03 1.575277e-02 4 86732400 86732474 75 + 1.664 1.467 -0.674
ENSG00000163629 E018 83.5102701 0.0005057613 1.044272e-09 6.075416e-08 4 86732592 86732766 175 + 1.845 1.518 -1.108
ENSG00000163629 E019 67.9696820 0.0006466630 3.966479e-08 1.619618e-06 4 86734303 86734456 154 + 1.758 1.434 -1.103
ENSG00000163629 E020 55.7454207 0.0006699234 5.641044e-04 6.256802e-03 4 86734737 86734875 139 + 1.661 1.468 -0.659
ENSG00000163629 E021 61.3792191 0.0026410396 2.387564e-04 3.097040e-03 4 86735594 86735746 153 + 1.703 1.488 -0.733
ENSG00000163629 E022 57.1430438 0.0007694910 2.989755e-03 2.334065e-02 4 86741634 86741816 183 + 1.665 1.509 -0.532
ENSG00000163629 E023 57.5892167 0.0006691004 8.609787e-04 8.780039e-03 4 86744966 86745128 163 + 1.670 1.489 -0.619
ENSG00000163629 E024 105.5684989 0.0004775422 2.320040e-05 4.336328e-04 4 86750470 86750887 418 + 1.929 1.761 -0.566
ENSG00000163629 E025 62.7365056 0.0012966971 2.637495e-01 5.030192e-01 4 86751027 86751124 98 + 1.689 1.663 -0.089
ENSG00000163629 E026 21.1228323 0.0087385566 2.710008e-01 5.109656e-01 4 86753009 86753065 57 + 1.197 1.344 0.516
ENSG00000163629 E027 62.6784651 0.0018375267 4.249370e-02 1.612209e-01 4 86758260 86758349 90 + 1.697 1.612 -0.290
ENSG00000163629 E028 0.0000000       4 86758669 86758677 9 +      
ENSG00000163629 E029 69.0906330 0.0016462501 1.263990e-02 6.899636e-02 4 86758678 86758785 108 + 1.743 1.634 -0.369
ENSG00000163629 E030 71.7037691 0.0041885163 1.016688e-04 1.516625e-03 4 86758942 86759073 132 + 1.769 1.545 -0.763
ENSG00000163629 E031 88.5486620 0.0286507902 2.001890e-02 9.595183e-02 4 86762727 86762953 227 + 1.856 1.666 -0.640
ENSG00000163629 E032 54.1903245 0.0013350572 3.394179e-04 4.133154e-03 4 86762954 86763008 55 + 1.648 1.434 -0.733
ENSG00000163629 E033 101.8776438 0.0004607302 1.817502e-06 4.794247e-05 4 86763009 86763190 182 + 1.917 1.715 -0.683
ENSG00000163629 E034 89.6132323 0.0145824714 2.895069e-03 2.277209e-02 4 86764593 86764724 132 + 1.861 1.675 -0.628
ENSG00000163629 E035 8.6387205 0.1715946420 6.643214e-01 8.125747e-01 4 86764725 86764739 15 + 0.881 0.855 -0.097
ENSG00000163629 E036 81.8477486 0.0090481363 2.909774e-03 2.285916e-02 4 86765395 86765488 94 + 1.819 1.646 -0.587
ENSG00000163629 E037 69.7742774 0.0024363529 8.321908e-03 5.080166e-02 4 86766432 86766517 86 + 1.744 1.620 -0.421
ENSG00000163629 E038 0.3559677 0.5604715463 1.000000e+00   4 86766518 86766653 136 + 0.112 0.000 -8.225
ENSG00000163629 E039 80.5491809 0.0036425660 2.181887e-04 2.873921e-03 4 86767817 86767976 160 + 1.815 1.620 -0.662
ENSG00000163629 E040 98.9907030 0.0006704377 5.852480e-05 9.537336e-04 4 86769769 86769983 215 + 1.898 1.733 -0.558
ENSG00000163629 E041 66.8037208 0.0006015815 4.391989e-02 1.648791e-01 4 86770101 86770199 99 + 1.720 1.643 -0.264
ENSG00000163629 E042 155.5083338 0.0003074744 8.792267e-01 9.409123e-01 4 86771171 86771535 365 + 2.062 2.108 0.155
ENSG00000163629 E043 95.4976118 0.0005276901 1.065632e-01 2.932488e-01 4 86772778 86772958 181 + 1.839 1.953 0.384
ENSG00000163629 E044 96.1017917 0.0058473984 2.253733e-01 4.597812e-01 4 86774373 86774531 159 + 1.841 1.954 0.382
ENSG00000163629 E045 101.7491309 0.0026037497 1.082658e-01 2.961333e-01 4 86775171 86775342 172 + 1.864 1.983 0.400
ENSG00000163629 E046 105.3398185 0.0007216918 4.796727e-01 6.868825e-01 4 86775442 86775652 211 + 1.900 1.908 0.028
ENSG00000163629 E047 62.5860770 0.0005953895 6.131702e-02 2.057669e-01 4 86780402 86780472 71 + 1.655 1.798 0.483
ENSG00000163629 E048 48.3374908 0.0008128829 3.217873e-06 7.882140e-05 4 86782201 86782262 62 + 1.504 1.813 1.050
ENSG00000163629 E049 76.5683191 0.0016815142 1.168981e-04 1.701842e-03 4 86784465 86784558 94 + 1.714 1.950 0.793
ENSG00000163629 E050 104.4206544 0.0005563626 2.110513e-04 2.796393e-03 4 86785231 86785368 138 + 1.857 2.053 0.659
ENSG00000163629 E051 90.7320177 0.0057751928 1.931009e-04 2.599317e-03 4 86785848 86785936 89 + 1.784 2.034 0.841
ENSG00000163629 E052 74.4462978 0.0115218419 4.033340e-03 2.935307e-02 4 86796874 86796929 56 + 1.699 1.944 0.825
ENSG00000163629 E053 112.5244553 0.0181063782 4.528895e-02 1.683176e-01 4 86799101 86799204 104 + 1.889 2.085 0.659
ENSG00000163629 E054 118.1334805 0.0029345054 2.396009e-04 3.105139e-03 4 86803709 86803857 149 + 1.907 2.113 0.694
ENSG00000163629 E055 80.5790838 0.0005375199 5.518997e-06 1.256371e-04 4 86805279 86805369 91 + 1.733 1.984 0.844
ENSG00000163629 E056 175.1573040 0.0002991422 9.061608e-23 3.646610e-20 4 86807560 86807897 338 + 2.044 2.382 1.131
ENSG00000163629 E057 136.2500248 0.0033105025 2.852306e-12 2.718222e-10 4 86809769 86809984 216 + 1.938 2.273 1.120
ENSG00000163629 E058 64.8134119 0.0766459391 2.983293e-03 2.329770e-02 4 86811046 86811108 63 + 1.593 2.006 1.397
ENSG00000163629 E059 126.7550256 1.4188803298 2.100626e-01 4.419252e-01 4 86814456 86815260 805 + 1.814 2.393 1.941