ENSG00000163607

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295864 ENSG00000163607 HEK293_OSMI2_6hA HEK293_TMG_6hB GTPBP8 protein_coding nonsense_mediated_decay 17.04258 4.892546 28.77834 1.132071 1.495499 2.553882 1.2377573 0.1804219 1.981062 0.18042188 0.4564546 3.3862674 0.06156667 0.02900000 0.06886667 0.03986667 0.508722330 0.008095413 TRUE  
ENST00000383677 ENSG00000163607 HEK293_OSMI2_6hA HEK293_TMG_6hB GTPBP8 protein_coding protein_coding 17.04258 4.892546 28.77834 1.132071 1.495499 2.553882 1.2653337 0.2883310 2.797067 0.09698052 0.1755484 3.2340777 0.07005417 0.08020000 0.09830000 0.01810000 0.829886948 0.008095413 FALSE  
ENST00000383678 ENSG00000163607 HEK293_OSMI2_6hA HEK293_TMG_6hB GTPBP8 protein_coding protein_coding 17.04258 4.892546 28.77834 1.132071 1.495499 2.553882 10.4477017 2.7664894 17.646634 0.92990559 0.9488839 2.6688766 0.58852083 0.52606667 0.61346667 0.08740000 0.807757313 0.008095413 FALSE  
ENST00000467752 ENSG00000163607 HEK293_OSMI2_6hA HEK293_TMG_6hB GTPBP8 protein_coding protein_coding 17.04258 4.892546 28.77834 1.132071 1.495499 2.553882 1.0539221 0.2101528 2.567263 0.21015277 0.6028141 3.5492631 0.07055000 0.07960000 0.08780000 0.00820000 0.556007528 0.008095413 FALSE  
ENST00000488781 ENSG00000163607 HEK293_OSMI2_6hA HEK293_TMG_6hB GTPBP8 protein_coding nonsense_mediated_decay 17.04258 4.892546 28.77834 1.132071 1.495499 2.553882 2.0954703 0.8531720 2.295478 0.40231535 0.3936721 1.4173457 0.13707083 0.15566667 0.07880000 -0.07686667 0.673560053 0.008095413 TRUE  
MSTRG.23435.2 ENSG00000163607 HEK293_OSMI2_6hA HEK293_TMG_6hB GTPBP8 protein_coding   17.04258 4.892546 28.77834 1.132071 1.495499 2.553882 0.4308555 0.4221992 0.456434 0.06449517 0.1314884 0.1099763 0.03942083 0.09483333 0.01633333 -0.07850000 0.008095413 0.008095413 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000163607 E001 2.731991 0.2283337192 5.121859e-01 7.096084e-01 3 112990452 112990973 522 + 0.463 0.588 0.593
ENSG00000163607 E002 3.572276 0.2605491345 8.185492e-01 9.071943e-01 3 112990974 112990983 10 + 0.575 0.579 0.018
ENSG00000163607 E003 4.870017 0.3387055574 7.634968e-01 8.747703e-01 3 112990984 112990984 1 + 0.675 0.706 0.128
ENSG00000163607 E004 4.870017 0.3387055574 7.634968e-01 8.747703e-01 3 112990985 112990986 2 + 0.675 0.706 0.128
ENSG00000163607 E005 6.952400 0.3914702122 5.348443e-01 7.255363e-01 3 112990987 112990987 1 + 0.781 0.895 0.446
ENSG00000163607 E006 9.763582 0.5055157320 3.945956e-01 6.240194e-01 3 112990988 112990990 3 + 0.869 1.126 0.952
ENSG00000163607 E007 18.154246 0.5965059268 2.325600e-01 4.681274e-01 3 112990991 112991008 18 + 1.088 1.434 1.219
ENSG00000163607 E008 127.522546 0.0212134308 9.281197e-02 2.689580e-01 3 112991009 112991335 327 + 1.964 2.112 0.497
ENSG00000163607 E009 2.261927 0.0094608160 2.395350e-01 4.761001e-01 3 112991418 112991558 141 + 0.466 0.231 -1.451
ENSG00000163607 E010 8.195398 0.1521156349 5.319547e-01 7.234365e-01 3 112991567 112992540 974 + 0.875 0.731 -0.570
ENSG00000163607 E011 103.108550 0.0004425853 3.833303e-02 1.504698e-01 3 112993026 112993124 99 + 1.881 1.995 0.380
ENSG00000163607 E012 142.710015 0.0004905763 2.273771e-01 4.622366e-01 3 112995135 112995265 131 + 2.045 2.027 -0.059
ENSG00000163607 E013 145.983979 0.0014580486 2.227341e-01 4.567013e-01 3 112996892 112996991 100 + 2.055 2.033 -0.072
ENSG00000163607 E014 131.206623 0.0012447863 3.317126e-01 5.705773e-01 3 112999446 112999559 114 + 2.010 2.000 -0.034
ENSG00000163607 E015 61.558065 0.0007646356 1.735567e-01 3.952643e-01 3 112999560 112999564 5 + 1.693 1.642 -0.174
ENSG00000163607 E016 178.265956 0.0005521762 2.209629e-01 4.545988e-01 3 113000850 113001092 243 + 2.140 2.127 -0.042
ENSG00000163607 E017 61.799698 0.0024813195 2.846547e-01 5.251935e-01 3 113001093 113001105 13 + 1.688 1.650 -0.128
ENSG00000163607 E018 183.163906 0.0016978510 6.530468e-05 1.046348e-03 3 113001106 113001969 864 + 2.167 2.042 -0.420
ENSG00000163607 E019 32.675326 0.0368156985 6.653431e-07 1.994538e-05 3 113014377 113016518 2142 + 1.250 1.799 1.883