ENSG00000163512

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295748 ENSG00000163512 HEK293_OSMI2_6hA HEK293_TMG_6hB AZI2 protein_coding processed_transcript 31.25612 15.41725 49.92781 3.984182 4.823928 1.694651 6.0890755 2.47365475 10.545521 0.59602686 0.6483763 2.087461 0.18862917 0.163966667 0.21330000 0.04933333 0.49475168 0.00770552 FALSE  
ENST00000334100 ENSG00000163512 HEK293_OSMI2_6hA HEK293_TMG_6hB AZI2 protein_coding protein_coding 31.25612 15.41725 49.92781 3.984182 4.823928 1.694651 6.9405805 3.95307451 9.347638 1.13000492 0.5743735 1.239524 0.25015417 0.253300000 0.18873333 -0.06456667 0.25201112 0.00770552 FALSE  
ENST00000420543 ENSG00000163512 HEK293_OSMI2_6hA HEK293_TMG_6hB AZI2 protein_coding protein_coding 31.25612 15.41725 49.92781 3.984182 4.823928 1.694651 6.9385746 4.47586804 8.252110 1.11844709 0.9888039 0.881123 0.24602083 0.300700000 0.16913333 -0.13156667 0.32393970 0.00770552 FALSE  
ENST00000462936 ENSG00000163512 HEK293_OSMI2_6hA HEK293_TMG_6hB AZI2 protein_coding retained_intron 31.25612 15.41725 49.92781 3.984182 4.823928 1.694651 0.6852806 0.00000000 3.492676 0.00000000 3.4926756 8.452314 0.01603750 0.000000000 0.05923333 0.05923333 1.00000000 0.00770552    
ENST00000476174 ENSG00000163512 HEK293_OSMI2_6hA HEK293_TMG_6hB AZI2 protein_coding retained_intron 31.25612 15.41725 49.92781 3.984182 4.823928 1.694651 6.7362637 3.58803098 11.630565 1.23483067 1.0770420 1.693882 0.19682500 0.221600000 0.23316667 0.01156667 0.96218153 0.00770552 FALSE  
ENST00000492044 ENSG00000163512 HEK293_OSMI2_6hA HEK293_TMG_6hB AZI2 protein_coding retained_intron 31.25612 15.41725 49.92781 3.984182 4.823928 1.694651 1.4289365 0.07193837 3.363501 0.07193837 0.5355738 5.363564 0.03324583 0.003366667 0.07060000 0.06723333 0.00770552 0.00770552 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000163512 E001 0.0000000       3 28315003 28315171 169 -      
ENSG00000163512 E002 0.1308682 0.0308619257 0.249890554   3 28319202 28319313 112 - 0.000 0.165 10.592
ENSG00000163512 E003 15.7998516 0.2338071632 0.968539965 0.98611526 3 28321047 28322352 1306 - 1.245 1.100 -0.516
ENSG00000163512 E004 257.9877765 1.4293278853 0.700907920 0.83622669 3 28322353 28324186 1834 - 2.414 2.326 -0.296
ENSG00000163512 E005 105.2582493 1.0509187724 0.558178457 0.74197329 3 28324187 28324305 119 - 2.003 1.994 -0.032
ENSG00000163512 E006 106.2863121 1.0811090783 0.651622589 0.80456403 3 28324306 28324454 149 - 2.023 1.965 -0.194
ENSG00000163512 E007 6.7379611 0.0364508101 0.597934132 0.76889794 3 28326490 28326831 342 - 0.887 0.844 -0.168
ENSG00000163512 E008 101.6329870 0.0006661278 0.008650243 0.05226120 3 28326832 28326950 119 - 2.026 1.938 -0.295
ENSG00000163512 E009 2.7153684 0.3986304968 0.375444796 0.60854453 3 28326951 28327002 52 - 0.603 0.385 -1.075
ENSG00000163512 E010 1.5172310 0.0122832283 0.369748620 0.60380193 3 28331689 28331689 1 - 0.445 0.285 -0.946
ENSG00000163512 E011 1.7083863 0.0112566842 0.689459250 0.82867705 3 28331690 28331690 1 - 0.446 0.379 -0.361
ENSG00000163512 E012 26.1382751 0.0727381703 0.234950365 0.47080107 3 28331691 28331825 135 - 1.320 1.542 0.767
ENSG00000163512 E013 57.6335413 0.0807380706 0.262211645 0.50138570 3 28331826 28331950 125 - 1.652 1.880 0.772
ENSG00000163512 E014 20.7999734 0.0961670366 0.220193649 0.45376597 3 28331951 28331954 4 - 1.201 1.470 0.936
ENSG00000163512 E015 145.7484174 0.0436978523 0.442650968 0.66048086 3 28332369 28332427 59 - 2.148 2.125 -0.079
ENSG00000163512 E016 0.4646582 0.0215553704 0.245145038   3 28332428 28332437 10 - 0.088 0.285 2.051
ENSG00000163512 E017 189.2051260 0.0622393897 0.361881669 0.59725000 3 28336737 28336827 91 - 2.267 2.225 -0.141
ENSG00000163512 E018 142.6536254 0.0556425825 0.392427714 0.62232231 3 28336828 28336885 58 - 2.142 2.111 -0.101
ENSG00000163512 E019 6.8159684 0.2456419124 0.011313260 0.06366003 3 28336886 28337122 237 - 0.995 0.376 -2.690
ENSG00000163512 E020 178.5661461 0.0584377513 0.537685601 0.72745638 3 28337937 28338036 100 - 2.230 2.225 -0.017
ENSG00000163512 E021 125.5252124 0.0243665880 0.460479167 0.67348221 3 28338493 28338545 53 - 2.082 2.065 -0.058
ENSG00000163512 E022 143.2534383 0.0004561811 0.318904616 0.55863407 3 28338546 28338615 70 - 2.126 2.168 0.140
ENSG00000163512 E023 1.2681187 0.0143786126 0.023553515   3 28338616 28338617 2 - 0.446 0.000 -11.528
ENSG00000163512 E024 168.9171097 0.2993316482 0.244651333 0.48182098 3 28340402 28340601 200 - 2.163 2.277 0.382
ENSG00000163512 E025 66.6275744 0.6021544670 0.304118519 0.54469472 3 28340602 28340622 21 - 1.754 1.892 0.468
ENSG00000163512 E026 1.1846583 0.0147083249 0.335915687   3 28341512 28341596 85 - 0.278 0.456 1.052
ENSG00000163512 E027 0.0000000       3 28341597 28341647 51 -      
ENSG00000163512 E028 1.2920612 0.0133590637 0.795652118   3 28348161 28348600 440 - 0.326 0.379 0.317
ENSG00000163512 E029 132.9902949 1.0715881195 0.343097615 0.58075631 3 28348601 28349050 450 - 2.024 2.224 0.670