ENSG00000163430

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295633 ENSG00000163430 HEK293_OSMI2_6hA HEK293_TMG_6hB FSTL1 protein_coding protein_coding 61.99806 22.43985 69.75124 0.5338351 0.8472589 1.63572 25.21379 12.089292 24.42607 0.7750109 0.9527424 1.014090 0.4879083 0.5376667 0.3503333 -0.18733333 0.001371738 0.001371738 FALSE TRUE
ENST00000424703 ENSG00000163430 HEK293_OSMI2_6hA HEK293_TMG_6hB FSTL1 protein_coding protein_coding 61.99806 22.43985 69.75124 0.5338351 0.8472589 1.63572 15.69116 3.340609 20.43157 0.6302514 0.9519323 2.609011 0.1851375 0.1498000 0.2927667 0.14296667 0.116455136 0.001371738 FALSE TRUE
ENST00000637333 ENSG00000163430 HEK293_OSMI2_6hA HEK293_TMG_6hB FSTL1 protein_coding miRNA 61.99806 22.43985 69.75124 0.5338351 0.8472589 1.63572 14.30529 5.202661 18.37040 0.2165303 1.9351465 1.818076 0.2330042 0.2322333 0.2628667 0.03063333 0.855799639 0.001371738   FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000163430 E001 1389.6768704 0.0012309880 4.983693e-09 2.506948e-07 3 120392293 120395667 3375 - 3.075 3.188 0.375
ENSG00000163430 E002 494.7053282 0.0002105444 3.404018e-03 2.578530e-02 3 120395668 120396222 555 - 2.641 2.713 0.238
ENSG00000163430 E003 260.1416537 0.0032023495 7.579224e-01 8.713151e-01 3 120396223 120396472 250 - 2.376 2.415 0.133
ENSG00000163430 E004 408.5753834 0.0018319100 1.218201e-01 3.187570e-01 3 120396473 120396890 418 - 2.591 2.574 -0.057
ENSG00000163430 E005 216.7518357 0.0003679916 1.412709e-01 3.493977e-01 3 120396891 120396973 83 - 2.316 2.299 -0.057
ENSG00000163430 E006 176.6493951 0.0002779106 5.280160e-01 7.206347e-01 3 120396974 120396996 23 - 2.221 2.225 0.011
ENSG00000163430 E007 233.7749506 0.0018680052 2.458432e-01 4.834058e-01 3 120399883 120399959 77 - 2.348 2.335 -0.043
ENSG00000163430 E008 1.9355111 0.0102448479 5.242498e-01 7.179638e-01 3 120399960 120400089 130 - 0.480 0.379 -0.534
ENSG00000163430 E009 296.4872022 0.0006382506 3.136153e-03 2.422299e-02 3 120402808 120402918 111 - 2.462 2.412 -0.166
ENSG00000163430 E010 277.2682078 0.0002835419 8.207023e-06 1.766689e-04 3 120403242 120403354 113 - 2.443 2.359 -0.279
ENSG00000163430 E011 191.6679995 0.0002473649 6.577396e-05 1.052873e-03 3 120404853 120404894 42 - 2.286 2.196 -0.302
ENSG00000163430 E012 210.0464272 0.0002290142 9.343705e-06 1.977917e-04 3 120404895 120404971 77 - 2.327 2.229 -0.325
ENSG00000163430 E013 198.6713740 0.0006244955 7.198392e-06 1.576545e-04 3 120409532 120409574 43 - 2.304 2.194 -0.367
ENSG00000163430 E014 230.3242700 0.0002240948 2.162758e-04 2.854925e-03 3 120409575 120409662 88 - 2.358 2.285 -0.243
ENSG00000163430 E015 0.8158242 0.0175021578 5.075296e-01   3 120409957 120410951 995 - 0.278 0.166 -0.949
ENSG00000163430 E016 154.1362692 0.0003373684 7.955961e-04 8.246492e-03 3 120410952 120410984 33 - 2.189 2.105 -0.280
ENSG00000163430 E017 4.3769989 0.0061642289 9.768078e-01 9.901656e-01 3 120410985 120411326 342 - 0.702 0.714 0.051
ENSG00000163430 E018 207.6690351 0.0103569021 3.627718e-01 5.979811e-01 3 120411854 120411983 130 - 2.302 2.274 -0.093
ENSG00000163430 E019 147.4008891 0.0500481475 1.609523e-01 3.782123e-01 3 120415923 120416027 105 - 2.080 2.253 0.578
ENSG00000163430 E020 1.6266934 0.3448340137 1.253655e-02 6.857908e-02 3 120421172 120421552 381 - 0.088 0.712 4.210
ENSG00000163430 E021 3.7024108 0.0122414116 3.428801e-04 4.166351e-03 3 120423527 120424076 550 - 0.370 0.927 2.471
ENSG00000163430 E022 2.2554940 0.0105490395 7.739142e-02 2.396274e-01 3 120438261 120438458 198 - 0.370 0.674 1.468
ENSG00000163430 E023 0.9232117 0.2517860725 7.640260e-02   3 120441268 120441404 137 - 0.087 0.470 3.133
ENSG00000163430 E024 95.2601029 0.0059563886 1.609801e-02 8.215816e-02 3 120450684 120450746 63 - 1.898 2.046 0.495
ENSG00000163430 E025 6.9154792 0.0044449229 3.636390e-01 5.987164e-01 3 120450747 120450797 51 - 0.820 0.950 0.496
ENSG00000163430 E026 78.1645669 0.0090593923 3.726020e-02 1.476351e-01 3 120450897 120450993 97 - 1.812 1.962 0.506