ENSG00000163399

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295598 ENSG00000163399 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP1A1 protein_coding protein_coding 358.9888 375.4672 341.3432 34.71882 10.62798 -0.13746 271.48759 277.88929 303.90212 9.552581 8.659495 0.1290921 0.7682708 0.7476333 0.8904667 0.1428333 0.015637890 0.008860369 FALSE TRUE
ENST00000369496 ENSG00000163399 HEK293_OSMI2_6hA HEK293_TMG_6hB ATP1A1 protein_coding protein_coding 358.9888 375.4672 341.3432 34.71882 10.62798 -0.13746 81.04254 94.34396 32.65242 25.807735 1.460263 -1.5304513 0.2142750 0.2435333 0.0956000 -0.1479333 0.008860369 0.008860369 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000163399 E001 1.8219806 0.0103554393 0.166082511 0.38527635 1 116372668 116372921 254 + 0.257 0.521 1.518
ENSG00000163399 E002 5.7231184 0.0494649698 0.141533225 0.34977657 1 116373244 116373251 8 + 0.919 0.732 -0.732
ENSG00000163399 E003 8.1388603 0.0788855365 0.165472920 0.38452477 1 116373252 116373255 4 + 1.048 0.872 -0.657
ENSG00000163399 E004 21.0205011 0.0931820542 0.960747385 0.98226995 1 116373256 116373268 13 + 1.295 1.351 0.195
ENSG00000163399 E005 22.5610545 0.0806756863 0.929050093 0.96655109 1 116373269 116373284 16 + 1.328 1.379 0.179
ENSG00000163399 E006 722.8043891 0.0591881676 0.083780670 0.25233457 1 116373285 116373523 239 + 2.927 2.789 -0.458
ENSG00000163399 E007 1.3089191 0.6263045872 0.819901096   1 116373867 116374241 375 + 0.264 0.380 0.743
ENSG00000163399 E008 0.4349185 0.0217681645 0.314253600   1 116382411 116382593 183 + 0.257 0.099 -1.655
ENSG00000163399 E009 0.6479912 0.1779814063 0.160623796   1 116383370 116383553 184 + 0.000 0.308 10.798
ENSG00000163399 E010 1336.4673783 0.0537508176 0.047789980 0.17452289 1 116384014 116384124 111 + 3.202 3.049 -0.509
ENSG00000163399 E011 1462.0045637 0.0579745550 0.052350763 0.18512578 1 116384783 116384842 60 + 3.243 3.086 -0.519
ENSG00000163399 E012 34.2839588 0.0587733601 0.001241241 0.01172822 1 116384843 116386144 1302 + 1.721 1.358 -1.244
ENSG00000163399 E013 1109.3104046 0.0617441427 0.066213867 0.21654286 1 116387288 116387302 15 + 3.121 2.968 -0.511
ENSG00000163399 E014 2923.1780592 0.0671619992 0.070380505 0.22548396 1 116387303 116387491 189 + 3.540 3.390 -0.499
ENSG00000163399 E015 2432.6021768 0.0641615800 0.059656526 0.20200288 1 116388131 116388244 114 + 3.463 3.308 -0.518
ENSG00000163399 E016 3.2309690 0.0171831829 0.001119116 0.01081313 1 116388245 116388525 281 + 0.849 0.359 -2.238
ENSG00000163399 E017 2435.2413422 0.0679199673 0.103984505 0.28881076 1 116388638 116388726 89 + 3.450 3.320 -0.431
ENSG00000163399 E018 1503.8618587 0.0584842337 0.132136850 0.33518849 1 116388727 116388772 46 + 3.226 3.123 -0.344
ENSG00000163399 E019 2264.8420573 0.0600105531 0.129740804 0.33142257 1 116388902 116389019 118 + 3.404 3.300 -0.348
ENSG00000163399 E020 4250.2721216 0.0644839681 0.130588196 0.33271459 1 116389439 116389701 263 + 3.677 3.574 -0.345
ENSG00000163399 E021 1635.5642879 0.0578557976 0.084250543 0.25325120 1 116389702 116389707 6 + 3.277 3.148 -0.429
ENSG00000163399 E022 15.8561770 0.0759258400 0.037867046 0.14927399 1 116389708 116389940 233 + 1.348 1.101 -0.876
ENSG00000163399 E023 3828.4860459 0.0156190822 0.028701463 0.12346231 1 116390213 116390408 196 + 3.609 3.546 -0.210
ENSG00000163399 E024 1065.2352845 0.1194840152 0.673151935 0.81833637 1 116390409 116390411 3 + 3.025 3.010 -0.050
ENSG00000163399 E025 2268.0447644 1.8991640462 0.606746509 0.77471271 1 116390782 116390891 110 + 3.298 3.370 0.240
ENSG00000163399 E026 2618.0786312 1.9377041809 0.603229987 0.77236694 1 116392854 116392988 135 + 3.354 3.435 0.271
ENSG00000163399 E027 0.8925621 0.0165257428 0.159872758   1 116392989 116393004 16 + 0.418 0.180 -1.653
ENSG00000163399 E028 3232.8902542 0.0008592151 0.073929725 0.23262433 1 116393531 116393723 193 + 3.487 3.503 0.052
ENSG00000163399 E029 3393.3972162 0.0015823550 0.670340558 0.81652019 1 116395110 116395285 176 + 3.493 3.533 0.132
ENSG00000163399 E030 3152.5217506 0.2211640498 0.297346146 0.53784032 1 116396598 116396734 137 + 3.419 3.524 0.350
ENSG00000163399 E031 3371.6882598 1.9915517074 0.566413353 0.74761791 1 116397888 116398038 151 + 3.433 3.560 0.424
ENSG00000163399 E032 3477.4892691 1.9949981173 0.556775817 0.74103686 1 116398621 116398789 169 + 3.438 3.577 0.464
ENSG00000163399 E033 3341.4855692 1.9687130653 0.527795455 0.72047567 1 116398930 116399084 155 + 3.399 3.569 0.566
ENSG00000163399 E034 2199.7168728 0.4105760982 0.242771638 0.47967597 1 116399420 116399470 51 + 3.215 3.389 0.579
ENSG00000163399 E035 2560.9388354 0.4386907250 0.242518517 0.47938695 1 116399471 116399543 73 + 3.276 3.457 0.600
ENSG00000163399 E036 3335.0538188 1.9474007729 0.489049606 0.69337010 1 116400861 116401006 146 + 3.366 3.581 0.714
ENSG00000163399 E037 3310.4077351 0.4088646060 0.189879969 0.41680328 1 116401130 116401260 131 + 3.359 3.580 0.734
ENSG00000163399 E038 2649.1843121 0.6998725276 0.241762559 0.47850683 1 116401554 116401655 102 + 3.231 3.494 0.872
ENSG00000163399 E039 11.6803366 0.2580171911 0.725083260 0.85116726 1 116401656 116402033 378 + 1.157 1.044 -0.410
ENSG00000163399 E040 2432.8359305 1.8309684460 0.441134666 0.65956008 1 116403884 116403975 92 + 3.198 3.456 0.855
ENSG00000163399 E041 2586.5868672 1.8511519619 0.445713761 0.66255680 1 116404416 116404774 359 + 3.227 3.481 0.845
ENSG00000163399 E042 0.0000000       1 116406109 116406398 290 +      
ENSG00000163399 E043 0.4458772 0.0217681645 0.967376054   1 116410135 116410261 127 + 0.147 0.180 0.346