ENSG00000163166

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000295321 ENSG00000163166 HEK293_OSMI2_6hA HEK293_TMG_6hB IWS1 protein_coding protein_coding 28.46431 23.30234 37.63967 4.994628 2.148354 0.6915435 21.933587 15.816415 29.745437 3.5200196 1.9884167 0.91081880 0.75046667 0.6751667 0.78983333 0.11466667 1.154073e-01 2.740293e-06 FALSE TRUE
MSTRG.19171.5 ENSG00000163166 HEK293_OSMI2_6hA HEK293_TMG_6hB IWS1 protein_coding   28.46431 23.30234 37.63967 4.994628 2.148354 0.6915435 1.548070 3.155312 1.585096 0.7137844 0.1516846 -0.98870461 0.06267500 0.1368000 0.04213333 -0.09466667 2.740293e-06 2.740293e-06 FALSE TRUE
MSTRG.19171.8 ENSG00000163166 HEK293_OSMI2_6hA HEK293_TMG_6hB IWS1 protein_coding   28.46431 23.30234 37.63967 4.994628 2.148354 0.6915435 1.925554 2.158602 2.135367 0.4942611 0.2750573 -0.01554077 0.07762083 0.0924000 0.05720000 -0.03520000 3.475575e-01 2.740293e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000163166 E001 0.2735028 0.0274424043 8.463339e-01   2 127436207 127436297 91 - 0.106 0.138 0.431
ENSG00000163166 E002 2.0405607 0.1879554280 3.440336e-01 0.5816583416 2 127469986 127470134 149 - 0.377 0.599 1.100
ENSG00000163166 E003 1.9096926 0.2431091033 4.954827e-01 0.6977954768 2 127470251 127470385 135 - 0.377 0.559 0.920
ENSG00000163166 E004 1.6206041 0.3138600325 6.883604e-01 0.8280461835 2 127480810 127480811 2 - 0.329 0.473 0.798
ENSG00000163166 E005 2.6222345 0.5210677501 6.649573e-01 0.8130070076 2 127480812 127480813 2 - 0.588 0.478 -0.520
ENSG00000163166 E006 10.8907369 0.0049911052 2.676575e-01 0.5073328112 2 127480814 127480831 18 - 1.019 1.149 0.471
ENSG00000163166 E007 18.2251342 0.0029950287 7.441580e-01 0.8631008041 2 127480832 127480835 4 - 1.267 1.311 0.153
ENSG00000163166 E008 26.1565495 0.0057934171 2.081164e-01 0.4395779293 2 127480836 127480854 19 - 1.381 1.495 0.392
ENSG00000163166 E009 272.9797674 0.0065407850 4.217532e-03 0.0303578990 2 127480855 127481175 321 - 2.368 2.508 0.466
ENSG00000163166 E010 2.8527534 0.0143952611 5.250015e-01 0.7184880874 2 127485874 127486033 160 - 0.608 0.513 -0.439
ENSG00000163166 E011 241.6781462 0.0046238068 7.539342e-04 0.0078911575 2 127486553 127486664 112 - 2.313 2.459 0.484
ENSG00000163166 E012 206.2319720 0.0039309218 1.244071e-02 0.0682116508 2 127489179 127489235 57 - 2.264 2.371 0.358
ENSG00000163166 E013 4.6365224 0.0053804395 5.606644e-01 0.7437484964 2 127489818 127489831 14 - 0.778 0.709 -0.278
ENSG00000163166 E014 258.0465107 0.0011133644 5.428768e-04 0.0060629338 2 127489832 127489943 112 - 2.365 2.472 0.357
ENSG00000163166 E015 260.6005208 0.0024472817 6.007296e-04 0.0065844522 2 127491971 127492088 118 - 2.360 2.483 0.410
ENSG00000163166 E016 228.3199142 0.0016532796 2.596673e-04 0.0033190935 2 127493281 127493410 130 - 2.304 2.426 0.408
ENSG00000163166 E017 161.4627867 0.0057154427 1.960897e-01 0.4246650223 2 127494872 127494954 83 - 2.180 2.248 0.227
ENSG00000163166 E018 211.8224083 0.0009868674 1.316057e-01 0.3343385604 2 127495998 127496148 151 - 2.303 2.361 0.191
ENSG00000163166 E019 189.2145192 0.0003552960 9.225132e-01 0.9635699897 2 127498140 127498237 98 - 2.272 2.290 0.058
ENSG00000163166 E020 2.4381775 0.0095799578 6.357021e-01 0.7940635379 2 127502579 127502814 236 - 0.577 0.511 -0.307
ENSG00000163166 E021 166.3895194 0.0004698707 1.095526e-01 0.2983386278 2 127502815 127502872 58 - 2.239 2.208 -0.104
ENSG00000163166 E022 297.5521033 0.0043100089 1.971542e-01 0.4260405473 2 127503387 127503573 187 - 2.489 2.455 -0.113
ENSG00000163166 E023 96.9401392 0.0056325000 1.444657e-01 0.3540991991 2 127503574 127503576 3 - 2.018 1.960 -0.194
ENSG00000163166 E024 381.4210956 0.0007628919 2.843056e-04 0.0035692780 2 127504684 127504997 314 - 2.609 2.546 -0.211
ENSG00000163166 E025 129.3256162 0.0011266358 6.419258e-02 0.2121261772 2 127504998 127505039 42 - 2.133 2.083 -0.168
ENSG00000163166 E026 112.1883072 0.0013151294 6.519456e-02 0.2143113019 2 127505040 127505054 15 - 2.073 2.018 -0.184
ENSG00000163166 E027 163.6166276 0.0003593400 1.850284e-02 0.0907287052 2 127505055 127505125 71 - 2.238 2.186 -0.174
ENSG00000163166 E028 98.1661151 0.0015505279 6.570810e-04 0.0070696572 2 127505126 127505132 7 - 2.046 1.924 -0.409
ENSG00000163166 E029 142.2157654 0.0004265696 3.619085e-05 0.0006330248 2 127505133 127505190 58 - 2.204 2.091 -0.376
ENSG00000163166 E030 109.8401777 0.0004286570 1.535475e-04 0.0021408777 2 127505191 127505210 20 - 2.094 1.977 -0.392
ENSG00000163166 E031 99.4879200 0.0106165921 9.567310e-03 0.0562566858 2 127505211 127505241 31 - 2.061 1.914 -0.492
ENSG00000163166 E032 125.7227579 0.0003812868 5.044230e-03 0.0348718208 2 127505242 127505306 65 - 2.135 2.059 -0.256
ENSG00000163166 E033 91.0364590 0.0008558229 4.802869e-04 0.0054973217 2 127505307 127505320 14 - 2.013 1.889 -0.419
ENSG00000163166 E034 82.4673599 0.0006008655 9.747994e-04 0.0097161265 2 127505321 127505327 7 - 1.972 1.854 -0.397
ENSG00000163166 E035 101.7566008 0.0004340943 4.114231e-03 0.0298050935 2 127505328 127505349 22 - 2.047 1.959 -0.298
ENSG00000163166 E036 88.9149683 0.0025606309 6.002382e-03 0.0397342545 2 127505350 127505387 38 - 1.999 1.890 -0.368
ENSG00000163166 E037 160.0335804 0.0421718716 6.505712e-01 0.8039084948 2 127505388 127505554 167 - 2.227 2.172 -0.186
ENSG00000163166 E038 170.1122800 0.5858246038 5.177509e-01 0.7134335707 2 127505555 127505752 198 - 2.209 2.255 0.151
ENSG00000163166 E039 0.0000000       2 127506692 127506719 28 -      
ENSG00000163166 E040 0.0000000       2 127514817 127514937 121 -      
ENSG00000163166 E041 122.0386997 0.0692764484 5.321525e-01 0.7235874127 2 127523676 127523791 116 - 2.067 2.113 0.155
ENSG00000163166 E042 110.6011551 0.0052639189 1.265438e-01 0.3263342803 2 127526175 127526382 208 - 2.011 2.093 0.276
ENSG00000163166 E043 50.0574983 0.0048716655 2.631298e-01 0.5023535272 2 127526383 127526410 28 - 1.672 1.751 0.266
ENSG00000163166 E044 44.2741536 0.0015151234 2.439644e-01 0.4809826434 2 127526411 127526489 79 - 1.621 1.699 0.265
ENSG00000163166 E045 9.0172778 0.0034991538 3.931662e-01 0.6229291661 2 127526636 127526886 251 - 1.030 0.948 -0.303