ENSG00000163138

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000467997 ENSG00000163138 HEK293_OSMI2_6hA HEK293_TMG_6hB PACRGL protein_coding nonsense_mediated_decay 8.882041 2.646957 14.48043 0.2601748 0.5761945 2.447254 1.22117111 0.48281285 1.0706321 0.25287290 0.63097704 1.1327637 0.17090833 0.18750000 0.07070000 -0.11680000 8.970226e-01 2.917154e-05 TRUE  
ENST00000503747 ENSG00000163138 HEK293_OSMI2_6hA HEK293_TMG_6hB PACRGL protein_coding nonsense_mediated_decay 8.882041 2.646957 14.48043 0.2601748 0.5761945 2.447254 0.99846786 0.16231280 2.1580025 0.16231280 0.37640351 3.6532646 0.08978750 0.06480000 0.14793333 0.08313333 4.405205e-01 2.917154e-05    
ENST00000506457 ENSG00000163138 HEK293_OSMI2_6hA HEK293_TMG_6hB PACRGL protein_coding protein_coding 8.882041 2.646957 14.48043 0.2601748 0.5761945 2.447254 0.13111168 0.15273968 0.2099383 0.15273968 0.20993825 0.4345325 0.02377500 0.06686667 0.01436667 -0.05250000 9.041030e-01 2.917154e-05    
ENST00000507634 ENSG00000163138 HEK293_OSMI2_6hA HEK293_TMG_6hB PACRGL protein_coding protein_coding 8.882041 2.646957 14.48043 0.2601748 0.5761945 2.447254 0.37149514 0.34660370 0.9302150 0.20493935 0.46787566 1.3986690 0.04534167 0.12936667 0.06666667 -0.06270000 9.600788e-01 2.917154e-05 TRUE  
ENST00000511160 ENSG00000163138 HEK293_OSMI2_6hA HEK293_TMG_6hB PACRGL protein_coding protein_coding 8.882041 2.646957 14.48043 0.2601748 0.5761945 2.447254 0.06082326 0.11889501 0.0000000 0.06228890 0.00000000 -3.6881245 0.01077083 0.05016667 0.00000000 -0.05016667 1.069205e-01 2.917154e-05    
ENST00000513861 ENSG00000163138 HEK293_OSMI2_6hA HEK293_TMG_6hB PACRGL protein_coding protein_coding 8.882041 2.646957 14.48043 0.2601748 0.5761945 2.447254 0.66351299 0.09197535 0.7884394 0.09197535 0.66329632 2.9689625 0.06299167 0.04026667 0.05200000 0.01173333 9.464337e-01 2.917154e-05 FALSE  
ENST00000514292 ENSG00000163138 HEK293_OSMI2_6hA HEK293_TMG_6hB PACRGL protein_coding protein_coding 8.882041 2.646957 14.48043 0.2601748 0.5761945 2.447254 0.19012164 0.26812409 0.4720823 0.13451890 0.03979547 0.7935509 0.02285000 0.09656667 0.03266667 -0.06390000 7.996896e-01 2.917154e-05    
ENST00000515339 ENSG00000163138 HEK293_OSMI2_6hA HEK293_TMG_6hB PACRGL protein_coding protein_coding 8.882041 2.646957 14.48043 0.2601748 0.5761945 2.447254 0.32953834 0.00000000 1.1382256 0.00000000 0.10122570 6.8432623 0.02957917 0.00000000 0.07836667 0.07836667 2.917154e-05 2.917154e-05    
MSTRG.24689.27 ENSG00000163138 HEK293_OSMI2_6hA HEK293_TMG_6hB PACRGL protein_coding   8.882041 2.646957 14.48043 0.2601748 0.5761945 2.447254 1.31562318 0.20283048 2.1801618 0.12230548 0.82710738 3.3632608 0.13508750 0.07183333 0.15523333 0.08340000 7.533830e-01 2.917154e-05 FALSE  
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000163138 E001 0.0000000       4 20696282 20696513 232 +      
ENSG00000163138 E002 0.0000000       4 20700413 20700418 6 +      
ENSG00000163138 E003 0.1779838 0.0338316893 1.0000000000   4 20700419 20700426 8 + 0.062 0.000 -8.914
ENSG00000163138 E004 0.4986023 0.0393430167 0.7037413075   4 20700427 20700435 9 + 0.164 0.000 -12.469
ENSG00000163138 E005 0.9523018 0.0158561636 0.9512933389   4 20700436 20700437 2 + 0.247 0.225 -0.173
ENSG00000163138 E006 0.9523018 0.0158561636 0.9512933389   4 20700438 20700438 1 + 0.247 0.225 -0.173
ENSG00000163138 E007 1.1302857 0.0153787590 0.7753884746   4 20700439 20700454 16 + 0.283 0.225 -0.436
ENSG00000163138 E008 1.2917014 0.0136968632 0.6493097675   4 20700455 20700457 3 + 0.317 0.225 -0.659
ENSG00000163138 E009 1.2917014 0.0136968632 0.6493097675   4 20700458 20700458 1 + 0.317 0.225 -0.659
ENSG00000163138 E010 1.2917014 0.0136968632 0.6493097675   4 20700459 20700459 1 + 0.317 0.225 -0.659
ENSG00000163138 E011 1.5839852 0.0157627581 0.9260484146 0.965131515 4 20700460 20700465 6 + 0.348 0.372 0.147
ENSG00000163138 E012 1.7454009 0.0412496586 0.9508930041 0.977430056 4 20700466 20700468 3 + 0.377 0.372 -0.032
ENSG00000163138 E013 2.4821568 0.0090784463 0.9951351211 0.999124016 4 20700469 20700471 3 + 0.476 0.482 0.033
ENSG00000163138 E014 3.3755268 0.0073748656 0.5265685543 0.719550018 4 20700472 20700472 1 + 0.592 0.482 -0.512
ENSG00000163138 E015 7.3616026 0.0043645945 0.5324702547 0.723868880 4 20700473 20700475 3 + 0.843 0.760 -0.328
ENSG00000163138 E016 7.9793066 0.0081013736 0.8763443861 0.939403901 4 20700476 20700476 1 + 0.862 0.852 -0.042
ENSG00000163138 E017 8.6441263 0.0471954827 0.8603336789 0.930548226 4 20700477 20700480 4 + 0.892 0.886 -0.024
ENSG00000163138 E018 19.5874159 0.0089792052 0.6848774773 0.825868934 4 20700481 20700578 98 + 1.201 1.254 0.186
ENSG00000163138 E019 13.3768710 0.0030362589 0.4694546479 0.679661924 4 20700579 20700611 33 + 1.069 0.993 -0.279
ENSG00000163138 E020 10.7788705 0.0113827429 0.1756723180 0.398025430 4 20700612 20700617 6 + 0.996 0.809 -0.712
ENSG00000163138 E021 20.3259329 0.0435837178 0.7315674454 0.855190731 4 20700618 20700670 53 + 1.235 1.180 -0.195
ENSG00000163138 E022 24.8743678 0.0016827691 0.6803254721 0.822927545 4 20700671 20700706 36 + 1.314 1.287 -0.095
ENSG00000163138 E023 24.5304090 0.0014416611 0.9662304161 0.985015005 4 20700707 20700747 41 + 1.304 1.316 0.044
ENSG00000163138 E024 19.9425511 0.0130213160 0.3718073193 0.605498987 4 20700748 20700787 40 + 1.238 1.144 -0.335
ENSG00000163138 E025 0.1426347 0.0324566910 1.0000000000   4 20701510 20701518 9 + 0.062 0.000 -11.038
ENSG00000163138 E026 0.7673035 0.0183818543 0.3444956070   4 20701519 20701667 149 + 0.247 0.000 -13.143
ENSG00000163138 E027 0.4279040 0.6787294836 1.0000000000   4 20701726 20701757 32 + 0.158 0.000 -11.687
ENSG00000163138 E028 4.6916686 0.0894466296 0.9238464226 0.964306644 4 20701758 20701884 127 + 0.678 0.646 -0.138
ENSG00000163138 E029 4.9072305 0.0061335845 0.3919837970 0.622019122 4 20702141 20702221 81 + 0.710 0.570 -0.603
ENSG00000163138 E030 0.2027342 0.0373805627 0.0927092902   4 20702651 20702674 24 + 0.000 0.226 13.188
ENSG00000163138 E031 0.2027342 0.0373805627 0.0927092902   4 20702675 20702740 66 + 0.000 0.226 13.188
ENSG00000163138 E032 44.0497085 0.0011345821 0.0849889924 0.254591419 4 20704466 20704533 68 + 1.569 1.461 -0.373
ENSG00000163138 E033 67.9571490 0.0008199800 0.9026909935 0.953189737 4 20704660 20704814 155 + 1.734 1.738 0.012
ENSG00000163138 E034 0.0000000       4 20707802 20707802 1 +      
ENSG00000163138 E035 27.8497514 0.0016467734 0.8052855460 0.899330281 4 20707803 20707870 68 + 1.354 1.382 0.100
ENSG00000163138 E036 22.8229666 0.0029183881 0.6920878635 0.830377327 4 20709683 20709773 91 + 1.283 1.255 -0.098
ENSG00000163138 E037 0.3337900 0.0299279309 0.2796505632   4 20709774 20709836 63 + 0.062 0.225 2.153
ENSG00000163138 E038 2.5157705 0.0397032392 0.4655159911 0.676965226 4 20712699 20712787 89 + 0.430 0.571 0.687
ENSG00000163138 E039 39.2173871 0.0009939018 0.8854652864 0.944191665 4 20712788 20712922 135 + 1.500 1.500 -0.002
ENSG00000163138 E040 1.8806905 0.1293889417 0.2164632668 0.449240374 4 20713076 20713431 356 + 0.318 0.576 1.356
ENSG00000163138 E041 44.4933995 0.0009374784 0.8292287492 0.913375846 4 20713432 20713539 108 + 1.557 1.552 -0.016
ENSG00000163138 E042 0.1779838 0.0338316893 1.0000000000   4 20713540 20713541 2 + 0.062 0.000 -11.035
ENSG00000163138 E043 0.9876510 0.0789918564 0.9553748973   4 20716107 20716248 142 + 0.248 0.224 -0.191
ENSG00000163138 E044 3.4779404 0.0074191748 0.2144043010 0.446829330 4 20718816 20718976 161 + 0.608 0.373 -1.169
ENSG00000163138 E045 11.2716579 0.0028771092 0.3872682961 0.618343962 4 20724808 20724888 81 + 0.967 1.075 0.397
ENSG00000163138 E046 0.1723744 0.0376987079 0.0927314528   4 20724889 20724889 1 + 0.000 0.226 13.185
ENSG00000163138 E047 47.9154325 0.0009139022 0.8682693032 0.935038304 4 20727285 20727397 113 + 1.580 1.599 0.065
ENSG00000163138 E048 113.4382260 0.0108853430 0.3064655023 0.547114057 4 20727398 20732557 5160 + 1.941 2.000 0.201
ENSG00000163138 E049 11.1140548 0.0437035413 0.0002476291 0.003193827 4 20752565 20752907 343 + 0.836 1.332 1.807