ENSG00000163069

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000381431 ENSG00000163069 HEK293_OSMI2_6hA HEK293_TMG_6hB SGCB protein_coding protein_coding 16.39646 8.640988 23.46754 2.04163 0.7219978 1.440344 5.5703061 1.8962904 9.0254114 0.33938892 0.1653436 2.2448224 0.30556250 0.22850000 0.384933333 0.15643333 0.003709808 0.003709808 FALSE TRUE
ENST00000506357 ENSG00000163069 HEK293_OSMI2_6hA HEK293_TMG_6hB SGCB protein_coding nonsense_mediated_decay 16.39646 8.640988 23.46754 2.04163 0.7219978 1.440344 0.4507239 0.6818052 0.1196626 0.03804886 0.1196626 -2.4156030 0.03115417 0.09433333 0.005433333 -0.08890000 0.054373745 0.003709808 TRUE FALSE
MSTRG.24867.1 ENSG00000163069 HEK293_OSMI2_6hA HEK293_TMG_6hB SGCB protein_coding   16.39646 8.640988 23.46754 2.04163 0.7219978 1.440344 0.9779120 0.2674321 2.1474455 0.08358414 0.1836784 2.9591176 0.05244583 0.03656667 0.091300000 0.05473333 0.210734656 0.003709808 TRUE TRUE
MSTRG.24867.3 ENSG00000163069 HEK293_OSMI2_6hA HEK293_TMG_6hB SGCB protein_coding   16.39646 8.640988 23.46754 2.04163 0.7219978 1.440344 3.6479400 2.6316969 4.8419585 1.31913590 1.1232596 0.8771023 0.24224583 0.24646667 0.207966667 -0.03850000 1.000000000 0.003709808 FALSE TRUE
MSTRG.24867.4 ENSG00000163069 HEK293_OSMI2_6hA HEK293_TMG_6hB SGCB protein_coding   16.39646 8.640988 23.46754 2.04163 0.7219978 1.440344 5.5866937 3.1637638 6.8057144 0.41510549 1.2513429 1.1026701 0.36022500 0.39413333 0.288333333 -0.10580000 0.686418129 0.003709808 FALSE FALSE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000163069 E001 0.1614157 0.0354383256 1.000000e+00   4 52014145 52014174 30 - 0.075 0.000 -7.889
ENSG00000163069 E002 123.2232398 0.0005069436 3.615828e-01 5.969830e-01 4 52020706 52021579 874 - 2.047 2.014 -0.109
ENSG00000163069 E003 316.2264479 0.0002110809 1.563014e-20 4.942936e-18 4 52021580 52023792 2213 - 2.492 2.286 -0.685
ENSG00000163069 E004 80.7104591 0.0097072036 7.468638e-01 8.648150e-01 4 52023793 52023969 177 - 1.848 1.874 0.086
ENSG00000163069 E005 117.8616880 0.0004077752 3.582526e-02 1.437743e-01 4 52023970 52024160 191 - 2.001 2.076 0.251
ENSG00000163069 E006 123.9018192 0.0007154807 1.695995e-03 1.499005e-02 4 52027968 52028099 132 - 2.013 2.123 0.370
ENSG00000163069 E007 81.0939802 0.0019245087 6.723103e-01 8.177815e-01 4 52028730 52028770 41 - 1.855 1.878 0.077
ENSG00000163069 E008 84.1975765 0.0006336477 5.961600e-01 7.677889e-01 4 52028771 52028828 58 - 1.871 1.895 0.081
ENSG00000163069 E009 108.1580901 0.0004026627 1.235549e-02 6.786052e-02 4 52028829 52028921 93 - 1.957 2.050 0.309
ENSG00000163069 E010 143.6216127 0.0005879831 4.186453e-03 3.019434e-02 4 52029678 52029863 186 - 2.080 2.171 0.307
ENSG00000163069 E011 1.6075182 0.0116215129 3.112426e-02 1.307156e-01 4 52031852 52031864 13 - 0.461 0.000 -13.458
ENSG00000163069 E012 5.4601689 0.0054510243 3.923688e-01 6.222870e-01 4 52031865 52031961 97 - 0.729 0.848 0.475
ENSG00000163069 E013 89.6135887 0.0020465539 1.011457e-01 2.838634e-01 4 52033431 52033640 210 - 1.884 1.955 0.237
ENSG00000163069 E014 0.5530924 0.0361922365 1.382244e-01   4 52038223 52038226 4 - 0.075 0.323 2.543
ENSG00000163069 E015 36.9853880 0.0116793588 6.600556e-01 8.100274e-01 4 52038227 52038299 73 - 1.522 1.555 0.112