ENSG00000162878

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000294964 ENSG00000162878 HEK293_OSMI2_6hA HEK293_TMG_6hB PKDCC protein_coding protein_coding 18.38564 23.07947 19.37721 2.186579 1.370351 -0.2521297 2.097451 1.451784 0.04522272 0.09861890 0.04522272 -4.72632438 0.13222917 0.06340000 0.002233333 -0.06116667 4.226242e-07 4.226242e-07 FALSE TRUE
ENST00000401498 ENSG00000162878 HEK293_OSMI2_6hA HEK293_TMG_6hB PKDCC protein_coding nonsense_mediated_decay 18.38564 23.07947 19.37721 2.186579 1.370351 -0.2521297 1.641644 4.497648 2.18439489 1.43502310 0.24980750 -1.03855155 0.07751667 0.19926667 0.113433333 -0.08583333 7.824649e-01 4.226242e-07 FALSE TRUE
ENST00000475868 ENSG00000162878 HEK293_OSMI2_6hA HEK293_TMG_6hB PKDCC protein_coding retained_intron 18.38564 23.07947 19.37721 2.186579 1.370351 -0.2521297 1.012399 1.279586 1.26755864 0.37566410 0.04885846 -0.01351892 0.05509583 0.05520000 0.065766667 0.01056667 8.727043e-01 4.226242e-07   FALSE
ENST00000480099 ENSG00000162878 HEK293_OSMI2_6hA HEK293_TMG_6hB PKDCC protein_coding processed_transcript 18.38564 23.07947 19.37721 2.186579 1.370351 -0.2521297 2.927242 3.326230 3.75975990 0.04950101 0.52950162 0.17625387 0.15238750 0.14676667 0.193000000 0.04623333 6.112844e-01 4.226242e-07 FALSE FALSE
ENST00000490302 ENSG00000162878 HEK293_OSMI2_6hA HEK293_TMG_6hB PKDCC protein_coding retained_intron 18.38564 23.07947 19.37721 2.186579 1.370351 -0.2521297 1.225353 1.973233 0.85133776 0.51399784 0.46202567 -1.20320311 0.06298333 0.08636667 0.040900000 -0.04546667 7.332368e-01 4.226242e-07 FALSE FALSE
ENST00000492861 ENSG00000162878 HEK293_OSMI2_6hA HEK293_TMG_6hB PKDCC protein_coding retained_intron 18.38564 23.07947 19.37721 2.186579 1.370351 -0.2521297 3.504078 3.572889 4.74194941 0.52674841 0.31482053 0.40739610 0.19111250 0.15423333 0.245066667 0.09083333 1.121662e-01 4.226242e-07 FALSE TRUE
MSTRG.18274.3 ENSG00000162878 HEK293_OSMI2_6hA HEK293_TMG_6hB PKDCC protein_coding   18.38564 23.07947 19.37721 2.186579 1.370351 -0.2521297 4.600519 5.162074 5.03072830 0.96769224 0.40043641 -0.03711072 0.25641250 0.22006667 0.265233333 0.04516667 8.359857e-01 4.226242e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000162878 E001 0.4646582 2.4347628028 0.491124878   2 42048021 42048043 23 + 0.183 0.141 -0.452
ENSG00000162878 E002 9.4064880 0.0038461445 0.007343055 0.04629049 2 42048044 42048397 354 + 0.667 1.049 1.486
ENSG00000162878 E003 3.7131140 1.3544568390 0.609963503 0.77684907 2 42048398 42048539 142 + 0.177 0.731 3.120
ENSG00000162878 E004 5.0893289 1.4574155281 0.912242778 0.95824708 2 42048540 42048578 39 + 0.411 0.820 1.831
ENSG00000162878 E005 44.3216253 0.0096190499 0.186408223 0.41231715 2 42048579 42048773 195 + 1.532 1.637 0.357
ENSG00000162878 E006 48.9007766 0.0015624117 0.823800164 0.91017465 2 42048774 42048838 65 + 1.665 1.653 -0.040
ENSG00000162878 E007 81.3360741 0.0005027062 0.586340266 0.76119641 2 42053239 42053361 123 + 1.892 1.870 -0.073
ENSG00000162878 E008 10.9232243 0.2298249211 1.000000000 1.00000000 2 42053362 42053541 180 + 1.010 1.039 0.108
ENSG00000162878 E009 135.4813241 0.0004246754 0.133370778 0.33704502 2 42054036 42054307 272 + 2.130 2.083 -0.157
ENSG00000162878 E010 25.2782553 0.0145856656 0.497469068 0.69916131 2 42054308 42054540 233 + 1.419 1.359 -0.209
ENSG00000162878 E011 18.6935502 0.0503674526 0.668312650 0.81510826 2 42054642 42054806 165 + 1.286 1.240 -0.160
ENSG00000162878 E012 15.7361378 0.1077250335 0.329067053 0.56807988 2 42054807 42054930 124 + 1.271 1.143 -0.454
ENSG00000162878 E013 8.4641664 0.1396246788 0.549684586 0.73606962 2 42054931 42054940 10 + 0.986 0.915 -0.268
ENSG00000162878 E014 39.8563943 0.0012776508 0.732276892 0.85560779 2 42054941 42054941 1 + 1.560 1.585 0.086
ENSG00000162878 E015 44.4707006 0.0010542372 0.736132434 0.85804534 2 42054942 42054956 15 + 1.607 1.630 0.078
ENSG00000162878 E016 70.3717763 0.0011509182 0.805504559 0.89938377 2 42054957 42055020 64 + 1.809 1.823 0.049
ENSG00000162878 E017 1.2247365 2.5115213024 0.790272556   2 42055021 42055192 172 + 0.175 0.369 1.434
ENSG00000162878 E018 1.7599756 2.4158967927 0.744696125 0.86350867 2 42055193 42055285 93 + 0.295 0.452 0.910
ENSG00000162878 E019 88.6824739 0.0004603846 0.169938840 0.39038403 2 42055286 42055393 108 + 1.871 1.929 0.195
ENSG00000162878 E020 1.8440856 1.6486433421 1.000000000 1.00000000 2 42055394 42055631 238 + 0.176 0.488 2.050
ENSG00000162878 E021 65.5128801 0.0008761206 0.421126152 0.64449445 2 42057221 42057255 35 + 1.757 1.798 0.140
ENSG00000162878 E022 133.0366549 0.0003795549 0.505055794 0.70434294 2 42057256 42057394 139 + 2.103 2.082 -0.069
ENSG00000162878 E023 15.5152380 0.0593264314 1.000000000 1.00000000 2 42057395 42057602 208 + 1.158 1.178 0.073
ENSG00000162878 E024 329.5394783 0.0010730398 0.422867012 0.64575561 2 42057603 42058517 915 + 2.490 2.474 -0.054