ENSG00000162775

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000369784 ENSG00000162775 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM15 protein_coding protein_coding 13.89433 7.755479 19.02345 1.055096 1.071562 1.29339 3.725988 1.0013561 8.5847594 1.0013561 0.4619734 3.0871662 0.23565417 0.17576667 0.45176667 0.27600000 2.617454e-01 6.008588e-06 FALSE TRUE
ENST00000617047 ENSG00000162775 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM15 protein_coding protein_coding 13.89433 7.755479 19.02345 1.055096 1.071562 1.29339 1.618824 1.9987605 0.0000000 1.0339352 0.0000000 -7.6501617 0.14785833 0.22643333 0.00000000 -0.22643333 1.905537e-01 6.008588e-06 FALSE TRUE
ENST00000652342 ENSG00000162775 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM15 protein_coding protein_coding 13.89433 7.755479 19.02345 1.055096 1.071562 1.29339 3.270102 0.7489568 5.9214954 0.2225772 0.2892071 2.9663062 0.19852917 0.09616667 0.31370000 0.21753333 2.151276e-03 6.008588e-06 FALSE TRUE
ENST00000654015 ENSG00000162775 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM15 protein_coding protein_coding 13.89433 7.755479 19.02345 1.055096 1.071562 1.29339 2.646823 2.8639053 2.1769532 0.4711530 0.3541668 -0.3940902 0.20689167 0.36586667 0.11473333 -0.25113333 6.008588e-06 6.008588e-06 FALSE TRUE
MSTRG.1784.10 ENSG00000162775 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM15 protein_coding   13.89433 7.755479 19.02345 1.055096 1.071562 1.29339 1.118384 0.0000000 1.0045309 0.0000000 0.5204696 6.6646690 0.08711667 0.00000000 0.05033333 0.05033333 4.016184e-01 6.008588e-06 FALSE TRUE
MSTRG.1784.2 ENSG00000162775 HEK293_OSMI2_6hA HEK293_TMG_6hB RBM15 protein_coding   13.89433 7.755479 19.02345 1.055096 1.071562 1.29339 1.375308 1.1070154 0.9523443 0.4347264 0.6187031 -0.2150241 0.11478333 0.13113333 0.04773333 -0.08340000 6.808142e-01 6.008588e-06 TRUE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000162775 E001 4.5901216 0.5597347237 6.512572e-01 8.043758e-01 1 110338506 110339322 817 + 0.807 0.448 -1.583
ENSG00000162775 E002 0.4702677 0.0217681645 9.719496e-01   1 110339323 110339376 54 + 0.157 0.170 0.132
ENSG00000162775 E003 0.7743180 0.0175664099 5.681516e-01   1 110339377 110339421 45 + 0.272 0.170 -0.867
ENSG00000162775 E004 0.9169527 0.0156708527 4.114899e-01   1 110339422 110339424 3 + 0.320 0.170 -1.188
ENSG00000162775 E005 2.7098291 0.0084322176 4.695431e-01 6.797032e-01 1 110339425 110339435 11 + 0.583 0.464 -0.565
ENSG00000162775 E006 24.7297555 0.0030562604 1.160301e-01 3.092273e-01 1 110339436 110339465 30 + 1.412 1.293 -0.413
ENSG00000162775 E007 67.0541769 0.0058856322 9.795034e-01 9.915661e-01 1 110339466 110339607 142 + 1.798 1.801 0.009
ENSG00000162775 E008 99.0418295 0.0015721329 6.019252e-01 7.714423e-01 1 110339608 110339883 276 + 1.958 1.985 0.091
ENSG00000162775 E009 56.9176104 0.0008992858 2.934937e-01 5.341720e-01 1 110339884 110340002 119 + 1.747 1.701 -0.156
ENSG00000162775 E010 649.2446209 0.0036422797 4.547476e-01 6.693085e-01 1 110340003 110342181 2179 + 2.785 2.776 -0.028
ENSG00000162775 E011 82.7316056 0.0017917605 6.951262e-02 2.238012e-01 1 110342182 110342268 87 + 1.862 1.947 0.287
ENSG00000162775 E012 69.0354741 0.0077503288 3.740855e-10 2.352901e-08 1 110342269 110342690 422 + 1.912 1.503 -1.386
ENSG00000162775 E013 103.2350637 0.0044781901 5.807164e-01 7.576513e-01 1 110345539 110345649 111 + 1.990 1.972 -0.061
ENSG00000162775 E014 174.3998175 0.0071148456 1.546664e-05 3.062809e-04 1 110346308 110346681 374 + 2.138 2.339 0.671