ENSG00000162601

1 Isoform Switch

Summary Plot

Only the isoforms with fraction > 5% are shown below.

Notes on IDR and IDR_w_binding: As the prediction of Intrinsically Disordered Regions (IDR) and Intrinsically Disordered Binding Regions (IDBR) are done by two different tools we require two things to annotate the Intrinsically Disordered Binding Regions (IDBR). Firstly the IDBR (predicted by ANCHOR2) must be a region of at least 15 amino acids (after the smoothing). Secondly the fraction of the IDBR which overlaps the IDR predictions (done by IUPred3, again after smoothing) must be at least 80%. When that is the case the IDR type will be annotated as “IDR_w_binding_region” instead of just “IDR”. The current default parameters have not been rigorously tested and should be considered experimental.

For the function of any other domain, please Click HERE to search it through Pfam database.

Results

isoform_id gene_id condition_1 condition_2 gene_name gene_biotype iso_biotype gene_overall_mean gene_value_1 gene_value_2 gene_stderr_1 gene_stderr_2 gene_log2_fold_change iso_overall_mean iso_value_1 iso_value_2 iso_stderr_1 iso_stderr_2 iso_log2_fold_change IF_overall IF1 IF2 dIF isoform_switch_q_value gene_switch_q_value PTC codingPotential
ENST00000472487 ENSG00000162601 HEK293_OSMI2_6hA HEK293_TMG_6hB MYSM1 protein_coding protein_coding 11.46565 6.061351 18.76068 1.191703 0.902619 1.628391 1.4494718 0.4314982 2.514316 0.11654046 0.71328853 2.5154131 0.10119583 0.08853333 0.13690000 0.04836667 7.835464e-01 4.59027e-07 FALSE TRUE
ENST00000483003 ENSG00000162601 HEK293_OSMI2_6hA HEK293_TMG_6hB MYSM1 protein_coding processed_transcript 11.46565 6.061351 18.76068 1.191703 0.902619 1.628391 2.8018439 3.2015972 1.465487 1.20467616 0.94331821 -1.1220999 0.32915833 0.47803333 0.07373333 -0.40430000 3.161565e-01 4.59027e-07 FALSE FALSE
ENST00000493821 ENSG00000162601 HEK293_OSMI2_6hA HEK293_TMG_6hB MYSM1 protein_coding processed_transcript 11.46565 6.061351 18.76068 1.191703 0.902619 1.628391 1.3401688 0.4703403 2.543144 0.08104649 0.25104536 2.4101459 0.09864583 0.07890000 0.13490000 0.05600000 1.808417e-01 4.59027e-07 FALSE TRUE
ENST00000622766 ENSG00000162601 HEK293_OSMI2_6hA HEK293_TMG_6hB MYSM1 protein_coding protein_coding 11.46565 6.061351 18.76068 1.191703 0.902619 1.628391 1.4953841 1.1450956 2.152248 0.30632796 0.45824128 0.9045197 0.17587083 0.18193333 0.11313333 -0.06880000 4.018931e-01 4.59027e-07 FALSE TRUE
ENST00000665648 ENSG00000162601 HEK293_OSMI2_6hA HEK293_TMG_6hB MYSM1 protein_coding nonsense_mediated_decay 11.46565 6.061351 18.76068 1.191703 0.902619 1.628391 1.3842546 0.1316726 2.709097 0.13167256 0.50807579 4.2624955 0.08380833 0.03536667 0.14413333 0.10876667 2.810425e-01 4.59027e-07 TRUE TRUE
MSTRG.1285.14 ENSG00000162601 HEK293_OSMI2_6hA HEK293_TMG_6hB MYSM1 protein_coding   11.46565 6.061351 18.76068 1.191703 0.902619 1.628391 0.8887645 0.1923871 1.935865 0.09257320 0.03733737 3.2652221 0.05882500 0.04180000 0.10346667 0.06166667 3.897367e-01 4.59027e-07 FALSE TRUE
MSTRG.1285.8 ENSG00000162601 HEK293_OSMI2_6hA HEK293_TMG_6hB MYSM1 protein_coding   11.46565 6.061351 18.76068 1.191703 0.902619 1.628391 0.8949838 0.0000000 2.877064 0.00000000 0.61787034 8.1734592 0.05180417 0.00000000 0.15716667 0.15716667 4.590270e-07 4.59027e-07 FALSE TRUE
  • Note:
    • The comparisons made can be identified as “from ‘condition_1’ to ‘condition_2’”, meaning ‘condition_1’ is considered the ground state and ‘condition_2’ the changed state. This also means that a positive dIF value indicates that the isoform usage is increased in ‘condition_2’ compared to ‘condition_1’. Since the ‘isoformFeatures’ entry is the most relevant part of the switchAnalyzeRlist object, the most-used standard methods have also been implemented to work directly on isoformFeatures.

2 Differential Exon Usage

Counts

All exons whithin this gene region are shown and numbering below.

Expression

All exons whithin this gene region are shown and numbering below.

Splicing

All exons whithin this gene region are shown and numbering below.

Transcripts

All isoforms whithin this gene region are shown below.

Results

groupID featureID exonBaseMean dispersion pvalue padj seqnames start end width strand HEK293_TMG_6hB HEK293_OSMI2_6hA log2fold_HEK293_OSMI2_6hA_HEK293_TMG_6hB
ENSG00000162601 E001 0.9099878 0.50135870 0.4174286969   1 58643440 58645384 1945 - 0.156 0.490 2.277
ENSG00000162601 E002 0.0000000       1 58646427 58646569 143 -      
ENSG00000162601 E003 0.0000000       1 58654739 58654742 4 -      
ENSG00000162601 E004 0.0000000       1 58654743 58654750 8 -      
ENSG00000162601 E005 46.3323786 0.68754658 0.1534642012 0.367289359 1 58654751 58655397 647 - 1.418 1.910 1.672
ENSG00000162601 E006 156.4254198 1.30066004 0.2628376573 0.502081107 1 58655398 58656243 846 - 1.950 2.408 1.530
ENSG00000162601 E007 405.0058871 1.71033635 0.4571519623 0.671146900 1 58656244 58658967 2724 - 2.416 2.697 0.937
ENSG00000162601 E008 28.3206543 0.56333185 0.5692067295 0.749680485 1 58658968 58659143 176 - 1.324 1.417 0.324
ENSG00000162601 E009 17.7468524 0.43101690 0.5723624267 0.751952940 1 58659144 58659152 9 - 1.128 1.246 0.417
ENSG00000162601 E010 33.3463360 0.61278259 0.5852707472 0.760497300 1 58659153 58659212 60 - 1.394 1.470 0.261
ENSG00000162601 E011 86.4843257 1.17261891 0.6671832336 0.814447516 1 58659213 58659665 453 - 1.803 1.848 0.153
ENSG00000162601 E012 36.3419494 0.70112179 0.8056117699 0.899447803 1 58659666 58659768 103 - 1.450 1.410 -0.138
ENSG00000162601 E013 26.5018250 0.55892293 0.6523241959 0.804926736 1 58659769 58659805 37 - 1.305 1.351 0.161
ENSG00000162601 E014 28.5931405 0.56278753 0.4944515968 0.697089032 1 58659806 58659908 103 - 1.317 1.461 0.497
ENSG00000162601 E015 60.7727795 0.82139827 0.5456124250 0.733148753 1 58659909 58660155 247 - 1.637 1.765 0.436
ENSG00000162601 E016 37.1992802 0.03171616 0.6256986633 0.787697571 1 58661170 58661227 58 - 1.453 1.501 0.165
ENSG00000162601 E017 53.4879355 0.03991410 0.1420442065 0.350490026 1 58661406 58661511 106 - 1.611 1.601 -0.034
ENSG00000162601 E018 8.6624545 0.12761998 0.9089387063 0.956531080 1 58661512 58663449 1938 - 0.832 1.002 0.641
ENSG00000162601 E019 2.1488441 0.05557850 0.8259467269 0.911467038 1 58663450 58663522 73 - 0.381 0.511 0.674
ENSG00000162601 E020 68.5836404 0.05350532 0.0041555872 0.030024007 1 58665499 58665631 133 - 1.740 1.529 -0.718
ENSG00000162601 E021 72.7597209 0.06071857 0.0136887068 0.073109327 1 58667038 58667226 189 - 1.761 1.585 -0.599
ENSG00000162601 E022 45.1675405 0.05281343 0.0519867478 0.184377451 1 58667847 58667921 75 - 1.551 1.436 -0.395
ENSG00000162601 E023 9.0754922 0.12767508 0.2301668102 0.465321879 1 58668430 58668566 137 - 0.903 0.790 -0.438
ENSG00000162601 E024 27.9058884 0.04312874 0.0099176000 0.057800082 1 58668632 58668682 51 - 1.363 1.155 -0.730
ENSG00000162601 E025 38.1470609 0.11132141 0.0983954092 0.278950401 1 58668984 58669038 55 - 1.481 1.362 -0.411
ENSG00000162601 E026 49.3857676 0.10360952 0.1270887526 0.327177534 1 58671870 58671958 89 - 1.583 1.504 -0.272
ENSG00000162601 E027 53.2221259 0.09475402 0.1222757441 0.319425820 1 58673573 58673650 78 - 1.615 1.540 -0.256
ENSG00000162601 E028 55.4094348 0.07774052 0.0403402356 0.155582728 1 58675477 58675580 104 - 1.640 1.505 -0.462
ENSG00000162601 E029 3.1932347 0.10064963 0.2601928888 0.499155439 1 58676772 58676925 154 - 0.547 0.395 -0.763
ENSG00000162601 E030 58.2560342 0.08541271 0.0236125165 0.107881313 1 58676926 58677056 131 - 1.667 1.485 -0.621
ENSG00000162601 E031 159.8825292 0.06882609 0.0756797879 0.236161934 1 58681785 58682545 761 - 2.083 2.020 -0.213
ENSG00000162601 E032 39.3601771 0.05189961 0.0639001143 0.211471024 1 58685153 58685251 99 - 1.490 1.387 -0.356
ENSG00000162601 E033 27.8935987 0.11515524 0.0392258971 0.152761243 1 58689038 58689116 79 - 1.362 1.121 -0.849
ENSG00000162601 E034 14.6318629 0.12099895 0.3370207451 0.575394083 1 58689117 58689293 177 - 1.076 1.031 -0.164
ENSG00000162601 E035 12.5323319 0.08984590 0.5775588884 0.755494821 1 58689294 58689367 74 - 1.001 1.033 0.119
ENSG00000162601 E036 16.1619621 0.07355006 0.1796242345 0.403459023 1 58689368 58689662 295 - 1.122 1.029 -0.338
ENSG00000162601 E037 3.8503701 0.04874736 0.0003067553 0.003798054 1 58690188 58690225 38 - 0.379 1.079 2.978
ENSG00000162601 E038 15.4494662 0.12554107 0.7610267809 0.873191831 1 58690226 58690249 24 - 1.075 1.186 0.398
ENSG00000162601 E039 32.5292258 0.04511655 0.8722235393 0.937139174 1 58690340 58690417 78 - 1.376 1.502 0.433
ENSG00000162601 E040 0.7547291 0.01722475 0.0522803222   1 58691712 58691804 93 - 0.107 0.509 2.998
ENSG00000162601 E041 2.6677027 0.01306026 0.3628785432 0.598050425 1 58692406 58692860 455 - 0.428 0.674 1.149
ENSG00000162601 E042 43.2356340 0.05761172 0.5813047668 0.758018965 1 58692861 58692931 71 - 1.473 1.690 0.740
ENSG00000162601 E043 45.1491582 0.08598252 0.5960024716 0.767751077 1 58695129 58695207 79 - 1.489 1.716 0.775
ENSG00000162601 E044 30.9252718 0.07403769 0.2724671265 0.512311495 1 58699985 58700091 107 - 1.309 1.611 1.041